Results 71 to 80 of about 11,397 (216)

OGG1-DNA interactions facilitate NF-κB binding to DNA targets [PDF]

Scientific Reports, 2017
AbstractDNA repair protein counteracting oxidative promoter lesions may modulate gene expression. Oxidative DNA bases modified by reactive oxygen species (ROS), primarily as 7, 8-dihydro-8-oxo-2′-deoxyguanosine (8-oxoG), which is repaired by 8-oxoguanine DNA glycosylase1 (OGG1) during base excision repair (BER) pathway.
Lang Pan, Wenjing Hao, Xu Zheng, Xianlu Zeng, Adeel Ahmed Abbasi, Istvan Boldogh, Xueqing Ba   +6 more
openaire   +2 more sources

Loss of Mitochondrial Tumor Suppressor Genes Expression Is Associated with Unfavorable Clinical Outcome in Head and Neck Squamous Cell Carcinoma: Data from Retrospective Study. [PDF]

PLoS ONE, 2016
Mitochondrial genes play important roles in cellular energy metabolism, free radical generation, and apoptosis. Dysregulation of these genes have long been suspected to contribute to the generation of reactive oxygen species (ROS), increased ...
Ishrat Mahjabeen, Mahmood Akhtar Kayani
doaj   +1 more source

Oxidative Stress: Molecular Mechanisms, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
Oxidative stress occurs when the reactive oxygen species (ROS) production overwhelms the ROS scavenging, which lead to genomic instability, epigenetic regulation, proteostasis imbalance, and lipid peroxidation, subsequently causing the occurrence and development of numerous diseases. ABSTRACT Although the physiological level of reactive oxygen species (
Yi Qin, Chen Qian, Wenhao Li, Qihan Wang, Qifeng Sheng, Zheqing Chen, Wei Zhang, Wenming Li, Gaoran Ge, Zhanjun Yan, Dechun Geng   +10 more
wiley   +1 more source

8-Oxoguanine DNA glycosylase protects cells from senescence via the p53-p21 pathway

Acta Biochimica et Biophysica Sinica
Cellular senescence is an important factor leading to pulmonary fibrosis. Deficiency of 8-oxoguanine DNA glycosylase (OGG1) in mice leads to alleviation of bleomycin (BLM)-induced mouse pulmonary fibrosis, and ...
Gao Shenglan, Chen Lujun, Lin Ziying, Xu Zhiliang, Wang Yahong, Ling Huayu, Wu Zijun, Yin Yu, Yao Weimin, Wu Keng, Liu Gang   +10 more
doaj   +1 more source

Pulmonary Vascular Endothelial Cells in Lung Diseases: Mechanisms, Therapeutic Strategies, and Future Directions

Cell Proliferation, Volume 59, Issue 2, February 2026.
The pathogenic mechanisms of pulmonary vascular endothelial cells (VECs) in lung diseases and their multimodal therapeutic strategies. ABSTRACT Pulmonary vascular endothelial cells (VECs) are essential for the normal function of the lung, through maintaining vascular barrier integrity, regulating blood flow, and participating in inflammatory responses ...
Qianyue Liu, Hongshuai Zheng, Jing Liu, Ming Gao, Faquan Lin, Lin Liao   +5 more
wiley   +1 more source

Increased ROS generation in subsets of OGG1 knockout fibroblast cells [PDF]

Mechanisms of Ageing and Development, 2007
Oxoguanine DNA glycosylase (OGG1) is a major base excision repair protein responsible for excision of the mutagenic 8-oxoguanosine (8-oxoG) lesions from the genome. Despite OGG1's importance, the moderate phenotype of Ogg1-null (Ogg1(-/-)) mice is not well understood.
Attila, Bacsi, Grzegorz, Chodaczek, Tapas K, Hazra, David, Konkel, Istvan, Boldogh   +4 more
openaire   +2 more sources

New alternatives in photoprotection: Preparation and evaluation of lamellar silicate derivatives and their use as sunscreens

International Journal of Cosmetic Science, Volume 48, Issue 1, Page 172-185, February 2026.
The use of nanotechnology in sunscreens has increased, with various filters and organoclays tested for new intercalated formulations. As animal toxicity tests decrease, New Approach Methodologies are favoured. The S4 + OMC‐NC improved cell survival under SSL and showed antimutagenic properties, making it a promising candidate for safe photoprotection ...
Daniel Mabundu Kibwila, Alice Simon, Letícia Coli Louvisse de Abreu, Carlos Rangel Rodrigues, Valeria Pereira de Sousa, Marcelo de Pádula, Lucio Mendes Cabral   +6 more
wiley   +1 more source

Small molecule inhibitor of OGG1 blocks oxidative DNA damage repair at telomeres and potentiates methotrexate anticancer effects

Scientific Reports, 2021
The most common oxidative DNA lesion is 8-oxoguanine which is mainly recognized and excised by the 8-oxoG DNA glycosylase 1 (OGG1), initiating the base excision repair (BER) pathway.
Juan Miguel Baquero, Carlos Benítez-Buelga, Varshni Rajagopal, Zhao Zhenjun, Raúl Torres-Ruiz, Sarah Müller, Bishoy M. F. Hanna, Olga Loseva, Olov Wallner, Maurice Michel, Sandra Rodríguez-Perales, Helge Gad, Torkild Visnes, Thomas Helleday, Javier Benítez, Ana Osorio   +15 more
doaj   +1 more source

8-Oxoguanine DNA Glycosylase-1 Augments Proinflammatory Gene Expression by Facilitating the Recruitment of Site-Specific Transcription Factors [PDF]

, 2014
Among the insidious DNA base lesions, 8-oxo-7,8-dihydroguanine (8-oxoG) is one of the most abundant, a lesion that arises through the attack by reactive oxygen species on guanine, especially when located in cis-regulatory elements.
Aguilera-Aguirre, Leopoldo, Ba, Xueqing, Boldogh, István, Brasier, Allan R., Bácsi, Attila, Luo, Jixian, Radak, Zsolt, Zeng, Xianlu   +7 more
core   +1 more source

Effect of prolonged voluntary wheel running on oxidative stress and defence mechanisms in cortex and hippocampus of healthy female rats

Experimental Physiology, Volume 111, Issue 2, Page 449-463, 1 February 2026.
Abstract Physical exercise promotes brain health and cognitive function possibly through mechanisms that include strengthened resistance to oxidative stress. However, limited research has explored the cumulative effects of regular voluntary exercise on both oxidative stress and defence mechanisms in hippocampus and cortex, two regions essential for ...
Camilla Myrup Holst, Iria Esperon‐Abril, Frederik Bryske Juhl, Jesper Emil Jakobsgaard, Jonas B. Kristiansen, Kristian Vissing, Tinna Stevnsner   +6 more
wiley   +1 more source