Journal of Lipid Research, 1994 This study examines various functional, biochemical, and structural changes in rat adrenocortical and ovarian granulosa cells that could account for the decline in lipoprotein-supported hormone production after cell treatment with the protein phosphatase
S Azhar, J A Frazier, L Tsai, E Reaven
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Toxins, 2013 In vivo, after administration by gavage to mice and rats, okadaic acid has been reported to produce lesions in liver, small intestine and forestomach.
Luis M. Botana +9 more
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IKKα negatively regulates ASC-dependent inflammasome activation. [PDF]
, 2014 The inflammasomes are multiprotein complexes that activate caspase-1 in response to infections and stress, resulting in the secretion of pro-inflammatory cytokines.
Alnemri, Emad S +19 more
core +1 more source
Risk Assessment of Pectenotoxins in New Zealand Bivalve Molluscan Shellfish, 2009–2019
Toxins, 2020 Pectenotoxins (PTXs) are produced by Dinophysis spp., along with okadaic acid, dinophysistoxin 1, and dinophysistoxin 2. The okadaic acid group toxins cause diarrhetic shellfish poisoning (DSP), so are therefore regulated.
Michael J. Boundy +5 more
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Insulin Action on Polyunsaturated Phosphatidic Acid Formation in Rat Brain: An “In Vitro” Model with Synaptic Endings from Cerebral Cortex and Hippocampus [PDF]
, 2009 The highly efficient formation of phosphatidic acid from exogenous 1-stearoyl-2-arachidonoyl-sn-glycerol (SAG) in rat brain synaptic nerve endings (synaptosomes) from cerebral cortex and hippocampus is reported.
Giusto, Norma Maria +2 more
core +1 more source
Lipophilic Toxins in Wild Bivalves from the Southern Gulf of California, Mexico
Marine Drugs, 2021 Most of the shellfish fisheries of Mexico occur in the Gulf of California. In this region, known for its high primary productivity, blooms of diatoms and dinoflagellates are common, occurring mainly during upwelling events.
Ignacio Leyva-Valencia +8 more
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PPM1D phosphatase, a target of p53 and RBM38 RNA-binding protein, inhibits p53 mRNA translation via dephosphorylation of RBM38. [PDF]
, 2015 PPM1D phosphatase, also called wild-type p53-induced phosphatase 1, promotes tumor development by inactivating the p53 tumor suppressor pathway.
Chen, X, Xu, E, Zhang, J, Zhang, M
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Posttranslational modifications of GLUT4 affect its subcellular localization and translocation [PDF]
, 2013 The facilitative glucose transporter type 4 (GLUT4) is expressed in adipose and muscle and plays a vital role in whole body glucose homeostasis. In the absence of insulin, only ~1% of cellular GLUT4 is present at the plasma membrane, with the vast ...
Bayer +64 more
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Okadaic Acid Is a Potent Angiogenesis Inducer [PDF]
Japanese Journal of Cancer Research, 1992 Okadaic acid, which is a non‐12‐0‐tetradecanoylphorbol‐13‐acetate (TPA)‐type tumor promoter and an inhibitor of protein phosphatases 1 and 2A, induced angiogenesis in the chorioallantoic membrane of the chick embryo. Its potent angiogenic activity was dose‐dependent. The minimum effective dose was 5 fmol/egg and the effective dose for 50% induction was
Oikawa, Tsutomu +3 more
openaire +2 more sources
Modulation of macrophage scavenger receptor transport by protein phosphorylation
Journal of Lipid Research, 1996 The identification of three highly conserved phosphorylation sites in the cytoplasmic domain of each of the monomeric subunits of the macrophage scavenger receptor suggests that protein phosphorylation may regulate this receptor pathway.
L G Fong
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