Results 71 to 80 of about 2,813,688 (177)

Exploring Autophagy Inducing Molecules: Targeting Diverse Pathways in Alzheimer's Disease Management

Medicinal Research Reviews, Volume 46, Issue 1, Page 272-298, January 2026.
ABSTRACT Neurodegenerative disorders, including Alzheimer's disease (AD), impose a significant burden on society due to their progressive nature and the associated healthcare costs. Autophagy, a vital cellular degradation process, has emerged as a promising therapeutic target in these disorders.
Baljinder Singh, Shubham Mahajan, Sadikalmahdi Abdella, Rehan Khan, Sanjay Garg   +4 more
wiley   +1 more source

The effects of protein phosphatase inhibitors on the duration of central sensitization of rat dorsal horn neurons following injection of capsaicin

Molecular Pain, 2006
Protein kinases and phosphatases catalyze opposing reactions of phosphorylation and dephosphorylation, which may modulate the function of crucial signaling proteins in central nervous system.
Fang Li, Wu Jing, Zhang Xuan, Willis William D   +3 more
doaj   +1 more source

Exploiting PP2A dependent and independent effects of forskolin for therapeutic targeting of KMT2A (MLL)‐rearranged acute leukaemia

British Journal of Pharmacology, Volume 182, Issue 24, Page 6043-6062, December 2025.
Background and Purpose Activation of Protein Phosphatase 2A (PP2A), via genetic and pharmacologic modulation of SET, has recently being identified as a promising strategy to therapeutically target acute myeloid leukaemia (AML) carrying KMT2A (MLL) chromosomal translocations (KMT2A‐r AML).
Yoana Arroyo‐Berdugo, Antonella Di Mambro, Volker Behrends, Michelle A. Sahai, Luca Cozzuto, Immacolata Zollo, Julia Ponomarenko, Owen Williams, John Gribben, Yolanda Calle, Bela Patel, Maria Teresa Esposito   +11 more
wiley   +1 more source

The Concise Guide to PHARMACOLOGY 2025/26: Ion channels

British Journal of Pharmacology, Volume 182, Issue S1, Page S152-S241, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Jörg Striessnig, Alasdair J. Gibb, Alistair A. Mathie, Emma L. Veale, Eamonn Kelly, Chloe J. Peach, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Richard W. Aldrich, Bernard Attali, Austin M. Baggetta, Elvir Becirovic, David J. Beech, Martin Biel, Roslyn M. Bill, Ana I. Caceres, William A. Catterall, Han Chow Chua, Alex C. Conner, Henry Danahay, Paul Davies, Katrien De Clerq, Markus Delling, Francesco Di Virgilio, Simonetta Falzoni, Wei Fang, Stefanie Fenske, Anna Fortuny‐Gomez, Samuel Fountain, George K. Chandy, Mohammad‐Reza Ghovanloo, Steve A. N. Goldstein, Martin Gosling, Christian Grimm, Stephan Grissmer, Kotdaji Ha, Tim G. Hales, Verena Hammelmann, Israel Hanukoglu, Meiqin Hu, Ad P. Ijzerman, Sairam V. Jabba, Mike Jarvis, Anders A. Jensen, Sven E. Jordt, Leonard K. Kaczmarek, Stephan Kellenberger, Charles Kennedy, Brian King, Philip Kitchen, Qiang Liu, Joseph W. Lynch, Rian W. Manville, Jessica Meades, Verena Mehlfeld, Annette Nicke, Stefan Offermanns, Edward Pérez‐Reyes, Leigh D. Plant, Stephan A. Pless, Lachlan D. Rash, Dejian Ren, Hussein N. Rubaiy, Mootaz M. Salman, Werner Sieghart, Lucia G. Sivilotti, Trevor G. Smart, Terrance P. Snutch, Paolo Tammaro, Jinbin Tian, James S. Trimmer, Charlotte Van den Eynde, Paola Vergani, Joris Vriens, Stephen G. Waxman, Aguan D. Wei, Brenda T. Winn, Heike Wulff, Haoxing Xu, Fan Yang, Lixia Yue, Xiaoli Zhang, Michael Zhu   +86 more
wiley   +1 more source

Foodborne Hazards and Novel Technologies in Ready‐to‐Eat Crustaceans

Food Frontiers, Volume 6, Issue 6, Page 2647-2672, November 2025.
Biological hazards, including Listeria monocytogenes, norovirus, Salmonella, and Vibrio spp., and chemical hazards, including heavy metals, biotoxins, pesticides, pharmaceuticals, and personal care products, are of great concern regarding crustaceans and their consumption.
Dongli Dong, Selene Pedrós‐Garrido, Daniel Hurley, James Lyng   +3 more
wiley   +1 more source

Tau Axonal Sorting and Interaction With Synaptic Plasticity Modulators Is Domain‐ and Isoform‐Dependent in Human iPSC‐Derived Neurons

Aging Cell, Volume 24, Issue 11, November 2025.
Efficient axonal Tau sorting requires the PRR2 domain but does not depend on AT8 or KXGS phosphorylation, the MT affinity, the C‐terminal repeat domains, or the N‐terminal tail of Tau. Human 0N4R‐Tau shows isoform‐specific interaction with modulators of synaptic plasticity involved in spine function under both normal and AD conditions.
Michael Bell‐Simons, Helen Breuer, Laura Wunderlich, Hanin Chmes, Daniel Adam, Jennifer Klimek, Sarah Buchholz, Hans Zempel   +7 more
wiley   +1 more source

Oceanography and Pacific Oyster Biochemical Composition in a Novel Oyster‐Growing Region

Aquaculture, Fish and Fisheries, Volume 5, Issue 5, October 2025.
ABSTRACT The farming of Pacific oysters (Crassostrea [Magallana] gigas) is a rapidly growing industry in Alaska, where farms represent some of the highest latitude oyster cultivation efforts in the world. Little is known about the nearshore oceanography where Alaskan farms are located, or how the subarctic marine context influences oyster tissue ...
Rebecca Cates, Juliana Cornett, Courtney Hart, Cody Pinger, John Harley, Kate Laboda, Kelly Koehler, Muriel Dittrich, Jordan Hollarsmith   +8 more
wiley   +1 more source

The marine biotoxin okadaic acid affects intestinal tight junction proteins in human intestinal cells

, 2019
Okadaic acid (OA) is a lipophilic phycotoxin that accumulates in the hepatopancreas and fatty tissue of shellfish. Consumption of highly OA-contaminated seafood leads to diarrhetic shellfish poisoning which provokes severe gastrointestinal symptoms ...
Dietrich, Jessica, Herek, Saadet, Lampen, Alfonso, Günzel, Dorothee, Grass, Irina, Hessel-Pras, Stefanie, Braeuning, Albert   +6 more
core   +1 more source

Exosome‐Based Therapeutics: A Natural Solution to Overcoming the Blood–Brain Barrier in Neurodegenerative Diseases

MedComm, Volume 6, Issue 9, September 2025.
Therapies for neurodegenerative diseases (NDs) are constrained by the blood–brain barrier (BBB), which limits drug delivery. Exosomes, with their ability to cross BBB and deliver drugs efficiently, emerge as a promising platform for central nervous system‐targeted therapies. ABSTRACT Neurodegenerative diseases present significant therapeutic challenges,
Min Sun, Feng Qin, Qian Bu, Yue Zhao, Xiaofeng Yang, Dingwen Zhang, Xiaobo Cen   +6 more
wiley   +1 more source

Characterization of fatty acid esters of okadaic acid and related toxins in blue mussels (Mytilus edulis) from Norway

, 2008
Marine algal toxins of the okadaic acid group can occur as fatty acid esters in blue mussels, and are commonly determined indirectly by transformation to their parent toxins by alkaline hydrolysis.
Alistair L. Wilkins, Trine Torgersen, Christopher O. Miles, Torgersen, Trine, Wilkins, Alistair L., Thomas Rundberget, Rundberget, Thomas, Miles, Christopher O.   +7 more
core   +1 more source