Results 101 to 110 of about 28,600 (213)

Initial dosage optimization of olanzapine in patients with bipolar disorder based on model-informed precision dosing: a study from the real world

Frontiers in Pharmacology
ObjectivesOlanzapine is used for treating bipolar disorder (BPD); however, the optimal initial dosing regimen is unclear. The present study aimed to investigate the optimal olanzapine initial dosage in patients with BPD via model-informed precision ...
Xiao Chen, Ke Hu, Hao-Zhe Shi, Liang Chen, Yi-Jia Zhang, Su-Mei He, Cun Zhang, Dong-Dong Wang   +7 more
doaj   +1 more source

PharmVar GeneFocus: CYP1A2—Clinical Impact, Genetic Variation, and Updated Nomenclature

Clinical Pharmacology &Therapeutics, Volume 120, Issue 2, Page 313-323, August 2026.
The Pharmacogene Variation Consortium (PharmVar) provides nomenclature for the highly polymorphic human CYP1A2 gene. CYP1A2 plays a crucial role in the biotransformation of several commonly used drugs, including antipsychotics, antidepressants, anxiolytics, and methylxanthines.
Katalin Monostory, Gonzalo Villapalos Garcia, Dora Koller, Solomon Adams, Chad A. Bousman, Evangelia Eirini Tsermpini, Michelle Whirl‐Carrillo, Amy J. Turner, Volker M. Lauschke, Mohamed Nagy, Erin C. Boone, Teri E. Klein, Pablo Zubiaur, Andrea Gaedigk   +13 more
wiley   +1 more source

A Review of Virtual Twins in Physiologically‐Based Pharmacokinetic Modeling and Simulation

Clinical Pharmacology &Therapeutics, Volume 120, Issue 2, Page 324-333, August 2026.
The novel application of Virtual Twins (VT) in PBPK (VT‐PBPK) presents the opportunity to advance precision dosing and accelerate the shift from one‐size‐fits‐all to targeted, individualized treatments. This review aims to: (1) critically evaluate existing research on the use of VTs in PBPK, (2) develop a conceptual definition of VT‐PBPK, (3) describe ...
Emily Mannix, Sam Mostafa, Amin Rostami‐Hodjegan, Thomas M. Polasek, Carl M. J. Kirkpatrick   +4 more
wiley   +1 more source

The Serotonin 2B (5‐HT2B) Receptor: A Narrative Review of Preclinical and Clinical Evidence on the Safety Considerations and Therapeutic Potential for the Treatment of Depression

Clinical Pharmacology &Therapeutics, Volume 120, Issue 2, Page 345-356, August 2026.
Major depressive disorder (MDD) and treatment‐resistant depression (TRD) remain leading causes of disability, providing the impetus for receptor‐level treatment strategies beyond monoamine reuptake. The serotonin 5‐HT2B receptor (5‐HT2BR) is uniquely positioned at the interface of central‐antidepressant mechanisms and peripheral cardiac risks.
Gia Han Le, Sabrina Wong, Danica E. Johnson, Diana K. Orsini, Yang Jing Zheng, Kayla M. Teopiz, Christine E. Dri, Joshua D. Rosenblat, Roger S. McIntyre   +8 more
wiley   +1 more source

Population Genomics Insights into Pharmacogenomic Differentiation Between East Asians and Europeans

Clinical Pharmacology &Therapeutics, Volume 120, Issue 2, Page 510-519, August 2026.
Genetic variation contributes substantially to interindividual and interpopulation differences in drug response, yet most pharmacogenomic studies remain biased toward European populations. Here, we systematically assessed pharmacogenomic variation across East Asians (EAS) and Europeans (EUR) using public genomic datasets and investigated the potential ...
Sihan Chen, Hongpu Chen, Shuhua Xu
wiley   +1 more source

Exploring Cerumen as an Alternative Matrix for Drug Detection and Quantification: Method Development and Application in Clinical Samples

Drug Testing and Analysis, Volume 18, Issue 8, Page 1065-1075, August 2026.
An LC–MS/MS method was developed for the detection of 33 psychoactive medications in cerumen (earwax) and applied to the samples of 60 psychiatric inpatient volunteers. The findings highlighted the utility of cerumen as an innovative biospecimen in clinical toxicological analysis.
Dimitrios Phaedon Kevrekidis, Helen G. Gika, Georgios Panagiotoglou, Eleni Parlapani, Pavlos Pavlidis, Nikolaos Raikos   +5 more
wiley   +1 more source

Nitrogen‐Doped Graphene Quantum Dots for Real‐Time Electrochemical Bioelectronics

Engineering Reports, Volume 8, Issue 8, August 2026.
Nitrogen‐doped graphene quantum dots offer promising routes toward real‐time electrochemical bioelectronics through tunable electronic, defect, and surface engineering. Understanding protein‐corona formation, biofouling, ionic interference, and signal drift may improve charge‐transfer stability and wearable sensing reliability, although fully ...
Seif Al Bustanji, Ahmed Basheer Ayyed, Subhashree Ray, Ahmed Aldulaimi, Sara Abdalkahar Sleeman, Rasulbek Eshmetov, Abduvali Sottarov, Ruchi Bharti, Ahmad Amiri   +8 more
wiley   +1 more source

Olanzapine as a cause of urinary incontinence: a case report.

Iranian Journal of Psychiatry, 2012
Olanzapine, an atypical antipsychotic, is one of the most commonly used antipsychotics. Though olanzapine is commonly associated with endocrine side effects, it is generally well tolerated by most patients and is rarely associated with urinary ...
Mobolaji Usman Dada, Lateef Olutoyin Oluwole, Patrick T Adegun, Peter O Tareo   +3 more
doaj  

A Remote Program for Navigator‐ and Pharmacist‐Led Management of Obesity Medications in Adults: Rationale, Design, and Implementation

Obesity Science &Practice, Volume 12, Issue 4, August 2026.
ABSTRACT Objective Remote interventions leveraging team‐based care may ameliorate persistent gaps in obesity medication implementation, but prospective studies are lacking. In this paper, the design, enrollment, and implementation of a remote intervention for obesity medications are described.
Bryn Falahee, John W. Ostrominski, Kavishwar B. Wagholikar, Ozan Unlu, David Zelle, Sanjay Kumar, Daniel Gabovitch, Michela Tucci, Austen Smith, Hunter Nichols, Irene G. McCarthy, Samar Mushtaque, Tabitha V. Rutkowski, Ashley C. McCarthy, Heather J. Baer, Christopher P. Cannon, Naomi D. L. Fisher, Jorge Plutzky, Caroline M. Apovian, Benjamin M. Scirica, Alexander J. Blood   +20 more
wiley   +1 more source

Prognostic Factors for Postoperative Complications. An Aggregate Protocol for 10 Observational Studies From the Danish TRIPLE‐A Cohort of 1.2 Million Surgeries

Acta Anaesthesiologica Scandinavica, Volume 70, Issue 7, August 2026.
ABSTRACT Background Postoperative complications substantially increase morbidity, mortality and healthcare costs. Understanding prognostic factors is essential for risk stratification, targeted prevention strategies, and development of prediction models.
Anders Peder Højer Karlsen, Asta Prescott, Caroline Folkersen, Jens Laigaard, Atena Saito, Caroline Lando Klammer, Mik Wetterslev, Emil Ipsen Ørskov, Mathilde Fahrendorff, Rebecca Kiær, Helene Holm Laigaard, Nichlas Hovmand, Lars Hyldborg Lundstrøm, Sebastian Buhl Rasmussen, Anders Kehlet Nørskov, Markus Harboe Olsen   +15 more
wiley   +1 more source