Results 121 to 130 of about 719,720 (299)

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

open access: yesFEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani   +6 more
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

open access: yesFEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point   +7 more
wiley   +1 more source

Cooperation and Competition in Intergenerational Experiments in the Field and the Laboratory [PDF]

open access: yes
There is economic pressure towards the postponement of the retirement age, but employers are still reluctant to employ older workers. We investigate the comparative behavior of juniors and seniors in experiments conducted both onsite with the employees ...
Gary Charness, Marie Claire Villeval
core  

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

open access: yesFEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li   +6 more
wiley   +1 more source

Cooperation and Competition in Intergenerational Experiments in the Field and in the Laboratory [PDF]

open access: yes
There is economic pressure towards the postponement of the retirement age, but employers are still reluctant to employ older workers. We investigate the comparative behavior of juniors and seniors in experiments conducted both onsite with the employees ...
Gary Charness, Marie-Claire Villeval
core  

Die Einstellungen zur Leistungs-, Lern- und Anpassungsfähigkeit älterer Arbeitnehmer/-innen und die subjektiv erlebte Diskriminierung [PDF]

open access: yes, 2006
An einer Stichprobe in zwei Schweizer Betrieben wurden die Einstellungen gegenüber älteren Arbeitnehmern/-innen erhoben. Es wurde dabei speziell der Frage nachgegangen, inwiefern die beobachtbare Gleichbehandlung von älteren und jüngeren Arbeitnehmern ...
Kluge, Annette
core  

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