Overview of molecular signatures of senescence and associated resources: pros and cons
FEBS Open Bio, EarlyView.Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas +6 more
wiley +1 more source
CHALLENGES OF AGING LABOR FORCE IN AN ORGANIZATION [PDF]
Innovative Issues and Approaches in Social Sciences, 2013 This paper examines the impacts of the changes of the composition of the ageing labor force on the skills and knowledge transfer in an organization. The changing individual needs of older individuals are creating powerful, labor dynamic incentives.
Marjan Petrišič, Milan Ambrož
doaj
Correction: Medical rehabilitation of older employees with migrant background in Germany: Does the utilization meet the needs? [PDF]
PLoS One, 2022 Schröder CC, Breckenkamp J, du Prel JB.
europepmc +1 more source
Hiring older employees: Do incentives of early retirement channels matter? [PDF]
We examine the impact of a Finnish reform in the 1990s that restricted the use of particular early retirement channels, unemployment pension and individual early retirement, and simultaneously changed the rules of firm size related experience rating in ...
Ilmakunnas, Pekka, Ilmakunnas, Seija
core +1 more source
Making Ends Meet: Getting and Spending in 2001 by Older People in France and the USA [PDF]
, 2007 The report analyzes budgets of older households based on data from official national surveys. Covering sources of income as well as major categories of expenditures, it gives insight into how countries differ in the ways older persons manage the ...
Charlotte Muller, Oleg Volkov
core
SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1
FEBS Open Bio, EarlyView.Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl +13 more
wiley +1 more source
Factors affecting work ability and influencing early retirement decisions of older employees: an attempt to integrate the existing approaches. [PDF]
Int J Occup Med Environ Health, 2022 Woźniak B +3 more
europepmc +1 more source
Layoff Tax and the Employment of the Elderly [PDF]
In 1996 Austria introduced a tax for the layoff of older workers, which was tightened in 2000. The regulation requires employers to pay a tax of up to 170 percent of the gross monthly income when they give notice to employees aged 50 or more. We use data
Mario Schnalzenberger +1 more
core +3 more sources
FEBS Open Bio, EarlyView.Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu +5 more
wiley +1 more source
Professional Development of Older Employees in Small and Medium Enterprises
Management and Business Administration. Central Europe, 2015 Purpose: The aim of the paper is to present and assess professional development opportunities for older employees in SME. Methodology: In the process of desk research, the author has discerned a number of characteristics of training activities conducted
Renata Trochimiuk
doaj