Results 141 to 150 of about 873 (179)

Oleandrin and Its Derivative Odoroside A, Both Cardiac Glycosides, Exhibit Anticancer Effects by Inhibiting Invasion via Suppressing the STAT-3 Signaling Pathway

International Journal of Molecular Sciences, 2018
The cardiac glycosides oleandrin and odoroside A, polyphenolic monomer compounds extracted from Nerium oleander, have been found to have antitumor effects on various tumors at low doses.
Hye Jung Kim, Sang Won Park, Hye Jung Kim   +2 more
exaly   +2 more sources

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Synthesis of oleandrin derivatives and their cytotoxic activity

Steroids, 2020
A series of oleandrin-4'-yl ester derivatives were designed, synthesized, and evaluated for their proliferation inhibition activities against tumor cell lines. Cytotoxicity data revealed that the C4' moiety had an important influence on cytotoxic activity. Several compounds that we designed and synthesized exhibit significant in vitro antiproliferative
Yanzhi, Zhang, Xubing, Chen, Yang, Zhou, Jinjun, Hou, Huali, Long, Zijia, Zhang, Min, Lei, Wanying, Wu   +7 more
openaire   +2 more sources

Effects of Oleandrin on Cardiovascular Hemodynamics in the Dog

American Journal of Veterinary Research, 1979
SUMMARY The cardiovascular effects of oleandrin, a cardiac glycoside isolated from Nerium oleander Linnaeus, were studied in anesthetized dogs with intact circulation. Oleandrin was given as a single iv injection at dosages of 0.01 (group I), 0.02 (group II), and 0.05 mg (group III)/kg of body weight, and measurements were made 0 (base line), 15, 30 ...
S I, Deavers, J P, Rosborough, H E, Hoff, J D, McCrady   +3 more
openaire   +2 more sources

A QUEST FOR OLEANDRIN IN DECAYED HUMAN TISSUE

Analytical Chemistry, 1993
This forensic case taught us several lessons. First, there is a need for improved sample cleanup and treatment of severely decayed tissue samples when trace determinations of target analytes are needed. With the exception of a few reports the literature is lacking in information with regard to the most modern sample preparation techniques.
G, Rule, L G, McLaughlin, J, Henion
openaire   +2 more sources

Antitumor effects of oleandrin in different types of cancers: Systematic review

Toxicon, 2022
Oleandrin, a cardiac glycoside isolated from the leaves of Nerium oleander, has known effects on the heart. Evidence from recent studies have highlighted its potential for anticancer properties. Therefore, we aimed to investigate the effects of oleandrin on cancer cell proliferation, viability and apoptosis in vitro and in vivo.
Cristiane Raquel Dias, Francischini, Carolina Rodrigues, Mendonça, Kênia Alves, Barcelos, Marco Augusto Machado, Silva, Ana Flávia Machado, Botelho   +4 more
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Comparative Cardiotoxicity of Low Doses of Digoxin, Ouabain, and Oleandrin

Cardiovascular Toxicology, 2020
The aim of this study was to evaluate the comparative effects of CGs on heart physiology. Twenty-eight Wistar rats were distributed into four groups (n = 7), control group received NaCl 0.9% every 24 h for 21 days; treated groups received respectively 50 μg/kg of digoxin (DIG), ouabain (OUA) and oleandrin (OLE) every 24 h for 21 days.
Ana F. M. Botelho, Ana L. S. Miranda, Thalita G. Freitas, Paula F. Milani, Tatiane Barreto, Jáder S. Cruz, Marília M. Melo   +6 more
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Isolation of oleandrin by preparative layer chromatography. Relationship between oleandrin content and cambium rhythm

Chromatographia, 1978
The oleandrin content of leaves of Nerium oleander L. has been evaluated monthly, over a period of 15 months, by a spectrophotometric method after solvent extraction, chromatographic separation on silica gel preparative layers and column purification.
B. Chiarlo, E. Cajelli, P. Gastaldo, P. Profumo   +3 more
openaire   +1 more source

Taking a critical look at oleandrin

C&EN Global Enterprise, 2020
Recent news that US President Donald J. Trump has expressed interest in researchers investigating oleandrin as a possible COVID-19 treatment has scientists raising alarms that the compound is unpro...
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The evaluation of the glycoside, oleandrin, on the embryo chick heart

Journal of the American Pharmaceutical Association (Scientific ed.), 1949
Embryonic chick hearts of 48- to 50-hour development were dissected by known methods and exposed to glycosidal-Tyrode solutions in prewarmed chambers of 39°. Atrioventricular block took place in the majority of instances and was taken as the end point. Occasionally dropped beats or diastolic arrest occurred first, and in such cases these were taken as ...
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Oleandrin-mediated oxidative stress in human melanoma cells.

Journal of experimental therapeutics & oncology, 2006
While certain cardiac glycoside compounds such as oleandrin, bufalin and digitoxin are known to be associated with potent cytotoxicity to human tumor cells, the mechanisms by which this effect is produced are not clear. We now demonstrate that incubation of human malignant melanoma BRO cells with oleandrin results in a time-dependent formation of ...
Robert A, Newman, Peiying, Yang, Walter N, Hittelman, Tao, Lu, Dah Hsi, Ho, Dan, Ni, Diana, Chan, Mary, Vijjeswarapu, Carrie, Cartwright, Susan, Dixon, Edward, Felix, Crandell, Addington   +11 more
openaire   +2 more sources