Results 121 to 130 of about 665 (160)
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Comparative Cardiotoxicity of Low Doses of Digoxin, Ouabain, and Oleandrin
Cardiovascular Toxicology, 2020The aim of this study was to evaluate the comparative effects of CGs on heart physiology. Twenty-eight Wistar rats were distributed into four groups (n = 7), control group received NaCl 0.9% every 24 h for 21 days; treated groups received respectively 50 μg/kg of digoxin (DIG), ouabain (OUA) and oleandrin (OLE) every 24 h for 21 days.
Ana F. M. Botelho +6 more
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Chromatographia, 1978
The oleandrin content of leaves of Nerium oleander L. has been evaluated monthly, over a period of 15 months, by a spectrophotometric method after solvent extraction, chromatographic separation on silica gel preparative layers and column purification.
B. Chiarlo +3 more
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The oleandrin content of leaves of Nerium oleander L. has been evaluated monthly, over a period of 15 months, by a spectrophotometric method after solvent extraction, chromatographic separation on silica gel preparative layers and column purification.
B. Chiarlo +3 more
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A QUEST FOR OLEANDRIN IN DECAYED HUMAN TISSUE
Analytical Chemistry, 1993This forensic case taught us several lessons. First, there is a need for improved sample cleanup and treatment of severely decayed tissue samples when trace determinations of target analytes are needed. With the exception of a few reports the literature is lacking in information with regard to the most modern sample preparation techniques.
G, Rule, L G, McLaughlin, J, Henion
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Taking a critical look at oleandrin
C&EN Global Enterprise, 2020Recent news that US President Donald J. Trump has expressed interest in researchers investigating oleandrin as a possible COVID-19 treatment has scientists raising alarms that the compound is unpro...
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The evaluation of the glycoside, oleandrin, on the embryo chick heart
Journal of the American Pharmaceutical Association (Scientific ed.), 1949Embryonic chick hearts of 48- to 50-hour development were dissected by known methods and exposed to glycosidal-Tyrode solutions in prewarmed chambers of 39°. Atrioventricular block took place in the majority of instances and was taken as the end point. Occasionally dropped beats or diastolic arrest occurred first, and in such cases these were taken as ...
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Oleandrin-mediated oxidative stress in human melanoma cells.
Journal of experimental therapeutics & oncology, 2006While certain cardiac glycoside compounds such as oleandrin, bufalin and digitoxin are known to be associated with potent cytotoxicity to human tumor cells, the mechanisms by which this effect is produced are not clear. We now demonstrate that incubation of human malignant melanoma BRO cells with oleandrin results in a time-dependent formation of ...
Robert A, Newman +11 more
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The effects of oleandrin on cardiac contractility in the normal dog.
Archives internationales de pharmacodynamie et de therapie, 1979The effects of oleandrin, a cardiac glycoside, were tested on the cardiovascular system of anesthetized dogs with an intact circulation. Oleandrin, administered intravenously, at dosages of 0.01 (Group I), 0.02 (Group II), and 0.05 (Group III) mg/kg, did not affect the mean heart rate significantly in any of the groups of dogs studied.
S, Deavers +2 more
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Examination of the effect of oleandrin on head and neck cancer cells
2021Oleandrin is a small molecule that belongs to a family of cardiac glycosides, which are naturally derived compounds that inhibit Na?/K? ATPase. Traditionally, members from this family have been used to treat heart failure. Our lab screened compounds that can suppress GRP78 gene expression, an important protein that regulates the balance between cancer ...
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Determinants of human and mouse melanoma cell sensitivities to oleandrin.
Journal of experimental therapeutics & oncology, 2009Oleandrin, a cardiac glycoside component of Nerium oleander, has been shown to induce apoptosis in malignant cells. While human tumor cells are very sensitive to growth inhibition by oleandrin, murine tumor cells are extremely resistant. Using human BRO and mouse B16 melanoma cell lines, we explored several possible determinants of cell sensitivity to ...
Yun, Lin +4 more
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