Results 81 to 90 of about 903,316 (302)

Engineering Immunoregenerative Therapy via an Immunomodulatory Binary Pharmacology Hydrogel Depot for Prolonged Allograft Survival

Advanced Science, EarlyView.
An immunomodulatory hydrogel (iGEL) forms spontaneously upon subcutaneous injection, acting as a tissue‐adhesive depot. It releases anti‐rejection and regenerative agents in response to inflammation, suppressing T‐cell activity, promoting vascular repair, and restoring allograft function without systemic immunosuppression.
Ning Wang, Ruiqi Sun, Yang Fu, Zhonghan Wu, Xinyu Tong, Hong Tang, Wentao Zhao, Zhi Liang, Jintao Zheng, Yanan Guan, Ke Zhou, Penghong Song, Shusen Zheng, Hangxiang Wang, Haiyang Xie   +14 more
wiley   +1 more source

Oleic acid-induced Ca2+ mobilization in human platelets: is oleic acid an intracellular messenger?

Journal of Lipid Mediators and Cell Signalling, 1997
The purpose of this study was to explore the effect of oleic acid (OA) on intracellular Ca2+ mobilization in human platelets. When applied extracellularly, OA produced a concentration dependent rise in cytosolic [Ca2+] ([Ca2+]cyt) when extracellular [Ca2+] (Ca2+]ext) was zero (presence of EGTA), suggesting that OA caused an intracellular release of Ca2+
Siafaka-Kapadai, A., Hanahan, D.J., Javors, M.A.   +2 more
openaire   +3 more sources

Comparing and Evaluating the Oil Composition of Olive Oil of 85 Olive Varieties in the Liangshan Region, China

Agronomy
The main objective of this study was to evaluate the quality and select the best varieties from 85 olive varieties in the Liangshan region, China, from the perspective of oil content, fatty acid, and triacylglycerol compositions. Although 85 varieties of
Zhuoya Zhang, Zhaoguo Tong, Yuanyuan Shao, Guangcan Su, Kaikai Li, Chunmei Li   +5 more
doaj   +1 more source

MASH Background Confers Enhanced Disease Susceptibility and Acetaminophen Toxicity in iPSC‐Derived Liver Organoids

Advanced Science, EarlyView.
This work establishes a novel method for generating multicellular liver organoids from control and MASH donor iPSCs. The model recapitulates several disease‐specific characteristics, with MASH donor‐derived organoids showing higher susceptibility. Lipidomic profiling of MASH organoids closely resembles MASH liver biopsies.
Ekta Minocha, Ashwani Kumar Gupta, Nate Schmidt, Richard M. Green, John G. Purdy, Jason A. Wertheim   +5 more
wiley   +1 more source

Long-chain saturated and monounsaturated fatty acids associate with development of premature infants up to 18 months of age.

, 2016
Myelination is important perinatally and highly dependent on long-chain saturated and monounsaturated fatty acids. Long-chain polyunsaturated fatty acids, nowadays often supplemented, inhibit oleic acid synthesis.
Ntoumani, E, Ntoumani, Eleni, Strandvik, B,, Sabel, Karl-Göran, Strandvik, Birgitta, Lundqvist, Cristina,, Lundqvist-Persson, C, Sabel, K-G, Lund University., Lundqvist, Cristina   +9 more
core   +1 more source

Mitochondrial SLC25A46 Rewires Fatty Acid Oxidation to Promote Cell Proliferation and Ferroptosis Evasion in Ovarian Cancer by Stabilizing CACT

Advanced Science, EarlyView.
Mitochondrial SLC25A46 is upregulated in ovarian cancer (OC) and correlates with poor prognosis. SLC25A46 stabilizes CACT to activate fatty acid oxidation, increasing ATP and NADPH production to drive cell proliferation and ferroptosis evasion. SLC25A46 silencing sensitizes OC cells to ferroptosis and carboplatin, offering a promising therapeutic ...
Yunge Gao, Jiatao Hao, Xiaohong Zhang, Meiting Long, Yujing Feng, Xiaoyue Liu, Xuejian Li, Shujuan Liu, Xin Guo, Xiaohui Lv   +9 more
wiley   +1 more source

First study of correlation between oleic acid content and SAD gene polymorphism in olive oil samples through statistical and bayesian modeling analyses

Lipids in Health and Disease, 2018
Background Virgin olive oil is appreciated for its particular aroma and taste and is recognized worldwide for its nutritional value and health benefits.
Rayda Ben Ayed, Karim Ennouri, Sezai Ercişli, Hajer Ben Hlima, Mohsen Hanana, Slim Smaoui, Ahmed Rebai, Fabienne Moreau   +7 more
doaj   +1 more source

Remote Magnetomechanical Neuromodulation Uncovers Therapeutic Mechanisms for Alleviating Parkinsonian Symptoms in Freely Moving Mice

Advanced Science, EarlyView.
Magnetomechanical neuromodulation using magnetic nanodiscs enables remote activation of neurons. In a hemiparkinsonian mouse model, alternating magnetic fields actuate the nanodiscs to generate torque that opens mechanosensitive ion channels within the subthalamic nucleus, thereby modulating basal ganglia motor circuitry.
Anouk Wolters, Lorenzo Signorelli, Christian Herff, Sophia Gimple, Renzo Riemens, Gunter Kenis, Kim Rijkers, Hamed Shabani, Jyh‐Jang Sun, Yasin Temel, Hans Clusmann, Danijela Gregurec, Sarah‐Anna Hescham   +12 more
wiley   +1 more source

Oxidative desaturation of eicosa-8,11-dienoic acid to eicosa-5,8,11-trienoic acid: comparison of different diets on oxidative desaturation at the 5,6 and 6,7 positions

Journal of Lipid Research, 1972
The oxidative desaturation of [1-14C]eicosa-8,11-dienoic acid to eicosa-5,8,11-trienoic acid by rat liver microsomes was studied, and the kinetic conditions appropriate to measure the specific activity of the enzyme were determined.
Juan C. Castuma, Angel Catala, Rodolfo R. Brenner   +2 more
doaj   +1 more source

Oleic Acid Toxicity and Fat Embolism.

Experimental Biology and Medicine, 1948
Conclusions and summaryIf, according to the findings of Davis and Dubois, albumin has the power of binding oleic acid in the ratio of 9 to 1, then the amounts of oleic acid injected exceeded the protective range in the dogs used in our experiments.The mechanism of the toxic action of oleic acid is problematical.
N C, JEFFERSON, H, NECHELES
openaire   +2 more sources