Results 91 to 100 of about 347,140 (343)

Intact olfaction in a mouse model of multiple system atrophy. [PDF]

PLoS ONE, 2013
BACKGROUND: Increasing evidence suggests that olfaction is largely preserved in multiple system atrophy while most patients with Parkinson's disease are hyposmic.
Florian Krismer, Gregor K Wenning, Yuntao Li, Werner Poewe, Nadia Stefanova   +4 more
doaj   +1 more source

Melatonin in the mammalian olfactory bulb [PDF]

Neuroscience, 2014
Melatonin is a neurohormone associated with circadian rhythms. A diurnal rhythm in olfactory sensitivity has been previously reported and melatonin receptor mRNAs have been observed in the olfactory bulb, but the effects of melatonin in the olfactory bulb have not been explored.
J T, Corthell, J, Olcese, P Q, Trombley
openaire   +3 more sources

Astrocytes Coordinate Neurovascular Coupling During Prolonged Sensory Demand via AQP4/TRPA1/BEST1/D‐Serine Signaling

Advanced Science, EarlyView.
Neuronal activation leads to astrocytic transient volume changes, activating transient receptor potential ankyrin 1 (TRPA1) channels, leading to Ca2+ influx. Activation of TRPA1 causes the release of D‐serine through BEST1. Finally, the augmented extracellular levels of D‐serine boost neuronal activity by binding GluN1‐containing NMDARs, leading to CBV
Kayoung Han, Minwoo Wendy Jang, Taeyoung Park, Ki Jung Kim, Victor James Drew, Sunpil Kim, Tai Young Kim, Mingu Gordon Park, Myeongju Kim, Seung Won Chung, Minah Suh, C. Justin Lee   +11 more
wiley   +1 more source

Tryptophan-5-HT pathway disorder was uncovered in the olfactory bulb of a depression mice model by metabolomic analysis

Frontiers in Molecular Neuroscience, 2022
Major depression (MD) is a severe mental illness that creates a heavy social burden, and the potential molecular mechanisms remain largely unknown. Lots of research demonstrate that the olfactory bulb is associated with MD.
Guanghui Chen, Siqi Zhou, Qiang Chen, Mengmeng Liu, Meixue Dong, Jiabao Hou, Benhong Zhou   +6 more
doaj   +1 more source

Broadcasting of cortical activity to the olfactory bulb

Cell Reports, 2015
Summary Odor representations are initially formed in the olfactory bulb, which contains a topographic glomerular map of odor molecular features. The bulb transmits sensory information directly to piriform cortex where it is encoded by distributed ...
Alison M. Boyd, Hiroyuki K. Kato, T. Komiyama, J. Isaacson   +3 more
semanticscholar   +1 more source

Non-neuronal expression of SARS-CoV-2 entry genes in the olfactory system suggests mechanisms underlying COVID-19-associated anosmia

Science Advances, 2020
: Altered olfactory function is a common symptom of COVID-19, but its etiology is unknown. A key question is whether SARS-CoV-2 (CoV-2) – the causal agent in COVID-19 – affects olfaction directly, by infecting olfactory sensory neurons or their targets ...
D. Brann, Tatsuya Tsukahara, Caleb Weinreb, M. Lipovsek, K. Van den Berge, Boying Gong, Rebecca K. Chance, Iain C. Macaulay, Hsin-Jung Chou, Russell B. Fletcher, D. Das, Kelly Street, H. R. de Bézieux, Yoon-Gi Choi, D. Risso, S. Dudoit, E. Purdom, J. Mill, R. Hachem, Hiroaki Matsunami, Darren W. Logan, Bradley J. Goldstein, M. Grubb, J. Ngai, S. R. Datta   +24 more
semanticscholar   +1 more source

Locus coeruleus stimulation modulates olfactory bulb evoked potentials [PDF]

, 1987
Field-evoked potentials from the main olfactory bulb in response to stimulation of the olfactory nerve and lateral olfactory tract were measured without and with conditioning stimulation of the locus coeruleus noradrenergic system.
Almli, C. Robert, Pérez, Hernán, Hernández, Alejandro   +2 more
core   +1 more source

AI‐Designed TREM1‐Targeted LYTAC Nanoparticles Reprogram the Neuroimmune Microenvironment in Traumatic Brain Injury

Advanced Science, EarlyView.
AI‐enabled de novo design of a TREM1 binder, integrated into a BBB‐crossing and macrophage‐targeted nanoplatform, enables TREM1 degradation and attenuates neuroinflammation, thereby promoting neuroprotection and tissue repair after traumatic brain injury. ABSTRACT Secondary neuroinflammation drives progressive damage after traumatic brain injury (TBI),
Yimin Huang, Yuan Liu, Huan Peng, Yu Ni, Zhengqiao Jiang, Chenxuan Yu, Xincheng Zhang, Huayu Kang, Yanchao Liu, Juan Chen, Kai Zhao, Lin Han, Xin Zou, Kai Shu, Xiaochuan Wang, Jian‐Zhi Wang, Ting Lei, Chao Gan, Jianfeng Liu, Huaqiu Zhang   +19 more
wiley   +1 more source

PBRM1 Deficiency in Microglia Leads to Excessive Neurogenesis and Autism‐Like Behaviors via the CCL5‐CCR1/5‐β‐catenin Signaling Axis

Advanced Science, EarlyView.
Microglial PBRM1 deficiency drives excessive hippocampal neurogenesis by enhancing CCL5–CCR1/5 signaling, leading to autism‐like behaviors. A pro‐inflammatory IL1α+/TNFα+ microglial subset is identified as a key cellular contributor to this process. PBRM1 represses Ccl5 expression at the transcriptional level.
Yang‐Yang Duan, Lin‐Fei Jiao, Pei‐Pei Liu, Chun‐Hui Duan, Xiao Li, Zi‐Han Zhang, Yue‐Qi Zhang, Xin‐Li Ouyang, Hong‐Zhen Du, Sha Liu, Yi Tang, Zhao‐Qian Teng, Chang‐Mei Liu   +12 more
wiley   +1 more source

Flexible Integration of Structurally Diverse Spatial Multi‐Omics With AgaeSMO

Advanced Science, EarlyView.
AgaeSMO is a versatile and robust deep learning framework for flexible cross‐integration of spatial multi‐omics data. Leveraging a GATs network with a graph attention module, it learns joint embedding across diverse modalities, enabling integration of both structurally paired (e.g., spatial transcriptome‐epigenome, transcriptome‐proteome, transcriptome‐
Kunpeng Liu, Jinpo Su, Haotian Zhou, Yilin Shen, Mengke Qin, Yingjie Luo, Tiancai Wang, Zhenglin Chen, Yuanyuan Wang, Xiaokai Ma   +9 more
wiley   +1 more source