Results 101 to 110 of about 339,145 (335)

TH/TRs–COL11A2 Axis Mediates Loss of a Differentiated Astrocyte State in Hypogyrified Brains

Advanced Science, EarlyView.
Using a gyrencephalic congenital hypothyroidism pig model, this study reveals cerebral atrophy and cortical hypogyrification. Single‐cell sequencing identifies astrocytes as major TH‐responsive cells, with the COL11A2‐enriched Astro‐2 state nearly absent.
Ying Zhang, Xiao Wang, Hongyan Ma, Pengcheng Lyu, Shuangjie Tian, Ruojun Zong, Jiani Chen, Gang Ren, Yongjiang Yang, Zichen Yang, Guosong Qin, Naishi Li, Yanfang Wang, Jianwei Jiao, Jianguo Zhao   +14 more
wiley   +1 more source

Intact olfaction in a mouse model of multiple system atrophy. [PDF]

PLoS ONE, 2013
BACKGROUND: Increasing evidence suggests that olfaction is largely preserved in multiple system atrophy while most patients with Parkinson's disease are hyposmic.
Florian Krismer, Gregor K Wenning, Yuntao Li, Werner Poewe, Nadia Stefanova   +4 more
doaj   +1 more source

Melatonin in the mammalian olfactory bulb [PDF]

Neuroscience, 2014
Melatonin is a neurohormone associated with circadian rhythms. A diurnal rhythm in olfactory sensitivity has been previously reported and melatonin receptor mRNAs have been observed in the olfactory bulb, but the effects of melatonin in the olfactory bulb have not been explored.
J T, Corthell, J, Olcese, P Q, Trombley
openaire   +3 more sources

Composition‐Aware Cross‐Sectional Integration for Spatial Transcriptomics

Advanced Intelligent Discovery, EarlyView.
Multi‐section spatial transcriptomics demands coherent cell‐type deconvolution, domain detection, and batch correction, yet existing pipelines treat these tasks separately. FUSION unifies them within a composition‐aware latent framework, modeling reads as cell‐type–specific topics and clustering in embedding space.
Qishi Dong, Zijian Huang, Xuanwu Wang, Zhenghui Feng, Wei Liu, Bingding Huang   +5 more
wiley   +1 more source

Tryptophan-5-HT pathway disorder was uncovered in the olfactory bulb of a depression mice model by metabolomic analysis

Frontiers in Molecular Neuroscience, 2022
Major depression (MD) is a severe mental illness that creates a heavy social burden, and the potential molecular mechanisms remain largely unknown. Lots of research demonstrate that the olfactory bulb is associated with MD.
Guanghui Chen, Siqi Zhou, Qiang Chen, Mengmeng Liu, Meixue Dong, Jiabao Hou, Benhong Zhou   +6 more
doaj   +1 more source

Broadcasting of cortical activity to the olfactory bulb

Cell Reports, 2015
Summary Odor representations are initially formed in the olfactory bulb, which contains a topographic glomerular map of odor molecular features. The bulb transmits sensory information directly to piriform cortex where it is encoded by distributed ...
Alison M. Boyd, Hiroyuki K. Kato, T. Komiyama, J. Isaacson   +3 more
semanticscholar   +1 more source

Non-neuronal expression of SARS-CoV-2 entry genes in the olfactory system suggests mechanisms underlying COVID-19-associated anosmia

Science Advances, 2020
: Altered olfactory function is a common symptom of COVID-19, but its etiology is unknown. A key question is whether SARS-CoV-2 (CoV-2) – the causal agent in COVID-19 – affects olfaction directly, by infecting olfactory sensory neurons or their targets ...
D. Brann, Tatsuya Tsukahara, Caleb Weinreb, M. Lipovsek, K. Van den Berge, Boying Gong, Rebecca K. Chance, Iain C. Macaulay, Hsin-Jung Chou, Russell B. Fletcher, D. Das, Kelly Street, H. R. de Bézieux, Yoon-Gi Choi, D. Risso, S. Dudoit, E. Purdom, J. Mill, R. Hachem, Hiroaki Matsunami, Darren W. Logan, Bradley J. Goldstein, M. Grubb, J. Ngai, S. R. Datta   +24 more
semanticscholar   +1 more source

Impact of Highly Effective Modulator Therapy on Olfactory‐Specific Gene Expression in People With Cystic Fibrosis

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Chronic rhinosinusitis is common in people with cystic fibrosis (PwCF). Highly effective modulator therapy (HEMT) has been shown to improve sinonasal outcomes. However, prior studies failed to show improvement in objective olfaction with HEMT, and the impact of HEMT on olfactory‐specific quality of life has yet to be studied ...
Michael R. Xiang, Ankit Chauhan, Gina Hong, Denis Hadjiliadis, Daniel Dorgan, Michael M. Rey, Samantha Kane, James N. Palmer, Nithin D. Adappa, Noam A. Cohen, Michael A. Kohanski, Jennifer E. Douglas   +11 more
wiley   +1 more source

The internal crest anatomy of Lambeosaurini (Hadrosauridae: Lambeosaurinae)

The Anatomical Record, EarlyView.
Abstract The supracranial crests of lambeosaurine hadrosaurids have long been a focus of study due primarily to their extreme morphology. The external anatomy of lambeosaurine crests is understood to be highly variable between species, but variation in their internal anatomy is less well understood.
Thomas W. Dudgeon, Courtney Brown, David C. Evans   +2 more
wiley   +1 more source

Gain Control and Sparse Representations in the Olfactory System of the Locust and Fly [PDF]

, 2010
The giant GABAergic neuron (GGN) is a single, paired, non-spiking neuron that arborizes extensively in the mushroom body (MB) of the locust (Leitch and Laurent, 1996), where it overlaps with the dendrites and the axons of Kenyon cells (KCs).
Papadopoulou, Maria
core   +1 more source