Results 181 to 190 of about 46,881 (221)

Unraveling Neurodevelopment: Synergistic Effects of Intrinsic Genetic Programs and Extrinsic Environmental Cues

open access: yesAdvanced Science, Volume 12, Issue 22, June 12, 2025.
Overview of the regulation of intrinsic and extrinsic signals during neurodevelopment. Intrinsic genetic signals from NSCs, in conjunction with cues from microglia and blood vessels, collaboratively regulate the proliferation of NSCs, their fate determination, synaptogenesis, synaptic pruning, neuronal survival, and death, as well as communication ...
Yanyan Wang   +4 more
wiley   +1 more source

Unilateral Versus Bilateral Endoscopic Resection of Olfactory Neuroblastoma: Pooled Analysis From Prospective and Retrospective Multicenter Data

open access: yesInternational Forum of Allergy &Rhinology, Volume 15, Issue 6, Page 585-593, June 2025.
ABSTRACT Background Olfactory neuroblastoma (ONB) is a rare sinonasal malignancy primarily treated with surgery. For tumors arising from the olfactory area, traditional treatment involves transcribriform resection of the anterior cranial fossa. Surgery can be performed with unilateral or bilateral resection depending on extent of involvement; however ...
Arash Abiri   +35 more
wiley   +1 more source

Alpha‐synuclein co‐pathology in Down syndrome‐associated Alzheimer's disease

open access: yesAlzheimer's &Dementia, Volume 21, Issue 6, June 2025.
Abstract INTRODUCTION Alpha‐synuclein (αSyn) seed amplification assay (SAA) enables in vivo study of αSyn but remains underexplored in Down syndrome‐associated Alzheimer's disease (DSAD). METHODS We analyzed αSyn‐SAA in cerebrospinal fluid (CSF) from 270 adults with Down syndrome, from the Down Alzheimer Barcelona Neuroimaging Initiative and from the ...
Alexander Maximilian Bernhardt   +29 more
wiley   +1 more source

A hypothesis explaining Alzheimer's disease, Parkinson's disease, and dementia with Lewy bodies overlap

open access: yesAlzheimer's &Dementia, Volume 21, Issue 6, June 2025.
Abstract Lewy body‐involving diseases (LBD) are commonly associated with Parkinson's disease (PD) featuring voluntary movement inhibition, due to dopaminergic neuron dysfunction in the substantia nigra. PD is clinically tracked through Lewy bodies (LB), composed of insoluble α‐synuclein aggregates sequestered with organelles, particularly inside ...
Victor Z. Lau   +4 more
wiley   +1 more source

Viral Etiologies and Histopathological Features of Olfactory Dysfunction: A Systematic Review

open access: yesHealth Science Reports, Volume 8, Issue 6, June 2025.
ABSTRACT Background and Aim Olfactory dysfunction associated with viral infections, including the recent SARS‐CoV‐2 pandemic, has raised significant clinical interest. Understanding the viral etiologies and histopathological characteristics of permanent olfactory dysfunction is essential for optimizing diagnostic and therapeutic strategies.
Kimia Motlagh Asghari   +5 more
wiley   +1 more source

Sensing Dog Brain Reactions to Smell by AI Speckle Pattern Analysis

open access: yesJournal of Biophotonics, Volume 18, Issue 6, June 2025.
The setup of our experiment is shown on Labrador, Johny, a canine participant of our research. The schematic of the setup features: green laser, digital camera, source of smell, and computer. Regions of the brain that were tested are highlighted. Note that the hippocampus and amygdala are on both sides of the dog's brain.
Ilana Propp   +5 more
wiley   +1 more source

Glutamatergic Regulation of miRNA‐Containing Intraluminal Vesicle Trafficking and Extracellular Vesicle Secretion From Cortical Neurons

open access: yesJournal of Extracellular Vesicles, Volume 14, Issue 6, June 2025.
ABSTRACT Neuronal extracellular vesicles (microvesicles and exosomes) are emerging secreted vesicular signals that play important roles in the CNS. Currently, little is known about how glutamatergic signalling affects the subcellular localisation of exosome precursor intraluminal vesicles (ILVs), microRNA (miR) packaging into ILVs and in vivo spreading
Marcela Bertolio   +9 more
wiley   +1 more source

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