Results 51 to 60 of about 83,412 (292)

Astrocytic TIA1‐Mediated Stress Granules Promote the Demyelination of Optic Neuritis by Sequestering mRNA of Cholesterol Synthesis Genes in an Experimental Autoimmune Encephalomyelitis Model

open access: yesAdvanced Science, EarlyView.
Astrocytic TIA1‐mediated stress granules (SGs) promote demyelination by sequestering the mRNA of cholesterol synthesis genes. In this model, astrocytic TIA1‐mediated SGs were increased in the optic nerves of EAE mice, leading to the downregulation of cholesterol synthesis genes such as HMGCS1 through sequestration of their mRNA into SGs, which ...
Zheyu Fang   +11 more
wiley   +1 more source

Neurogenesis dynamics in the olfactory bulb: deciphering circuitry organization, function, and adaptive plasticity

open access: yesNeural Regeneration Research
Adult neurogenesis persists after birth in the subventricular zone, with new neurons migrating to the granule cell layer and glomerular layers of the olfactory bulb, where they integrate into existing circuitry as inhibitory interneurons.
Moawiah M. Naffaa
doaj   +1 more source

Cytokines and olfactory bulb microglia in response to bacterial challenge in the compromised primary olfactory pathway

open access: yesJournal of Neuroinflammation, 2012
Background The primary olfactory pathway is a potential route through which microorganisms from the periphery could potentially access the central nervous system.
Herbert Rosalind P   +5 more
doaj   +1 more source

gnSPADE: Incorporating Gene Network Structures Enhances Reference‐Free Deconvolution in Spatial Transcriptomics

open access: yesAdvanced Intelligent Systems, EarlyView.
gnSPADE integrates gene‐network structures into a probabilistic topic modeling framework to achieve reference‐free cell‐type deconvolution in spatial transcriptomics. By embedding gene connectivity within the generative process, gnSPADE enhances biological interpretability and accuracy across simulated and real datasets, revealing spatial organization ...
Aoqi Xie, Yuehua Cui
wiley   +1 more source

The Importance of Olfaction for Mixed Paternity in Birds

open access: yesEcology and Evolution
Olfaction can aid individuals in finding genetically compatible mates in many animals, while high levels of mixed paternity may result from a limited ability to evaluate their mate's genetic profile against their own before mating.
Charlotta Kvarnemo   +3 more
doaj   +1 more source

Intact olfaction in a mouse model of multiple system atrophy. [PDF]

open access: yesPLoS ONE, 2013
BACKGROUND: Increasing evidence suggests that olfaction is largely preserved in multiple system atrophy while most patients with Parkinson's disease are hyposmic.
Florian Krismer   +4 more
doaj   +1 more source

Functional Relevance of Dual Olfactory Bulbs in Olfactory Coding [PDF]

open access: yeseneuro, 2019
Abstract Bilateral convergence of external stimuli is a common feature of vertebrate sensory systems. This convergence of inputs from the bilateral receptive fields allows higher order sensory perception, such as depth perception in the vertebrate visual system and stimulus localization in the auditory system.
Kuruppath, Praveen   +2 more
openaire   +3 more sources

The role of two anatomically separate olfactory bulbs in shark food odor tracking [PDF]

open access: yes, 2017
Most sharks have well-developed olfactory systems and depend to a large degree on odor information to locate food, home and navigate, and possibly detect predators and mates.
Lohe, Adrienne
core   +1 more source

Unveiling a New Link: Cholesterol Deficiency in Smith–Lemli–Opitz and Niemann–Pick C as a Driver of Ciliopathies

open access: yesAmerican Journal of Medical Genetics Part A, EarlyView.
ABSTRACT The ciliopathies are a group of genetic disorders caused by defective function of either the primary cilia (a large number) or the motile cilia (a much smaller number). These have been defined as diseases with mutations in genes encoding individual ciliary or cilia‐associated proteins.
Robert P. Erickson   +1 more
wiley   +1 more source

Open housing drives the expression of immune response genes in the nasal mucosa, but not the olfactory bulb. [PDF]

open access: yesPLoS ONE, 2017
Nasal mucosa and olfactory bulb are separated by the cribriform plate which is perforated by olfactory nerves. We have previously demonstrated that the cribriform plate is permissive for T cells and monocytes and that viruses can enter the bulb upon ...
Carolin Piotrowski   +7 more
doaj   +1 more source

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