Rapid generation of prion disease models using AAV‐delivered PrP variants in knockout mice
Brain Pathology, EarlyView.We developed a rapid AAV‐based system to generate prion disease models in weeks rather than months. Following systemic AAV9P31 delivery of modified PrP to knockout mice, we achieved brain‐wide expression and successful propagation of both classical (RML) and atypical (GSS‐A117V) prion strains.
Maitena San‐Juan‐Ansoleaga +11 more
wiley +1 more source
British Journal of Pharmacology, EarlyView.Theorized mechanism of dopamine homeostasis restoration in the nucleus accumbens core induced by a psychedelic intervention. Abstract Psychedelics have garnered great attention in recent years as treatments for major depressive disorder (MDD) and treatment‐resistant depression because of their ability to alter consciousness and afflicted cognitive ...
Lucas Wittenkeller +3 more
wiley +1 more source
Human olfaction: odour coding and cross-modal concept representation in single olfactory cortex neurons. [PDF]
Signal Transduct Target TherBeiersdorfer A, Rothermel M, Lohr C.
europepmc +1 more source
Multidimensional representation of odors in the human olfactory cortex
, 2016 Arnaud Fournel +4 more
openalex +2 more sources
Multiple speckle exposure imaging for the study of blood flow changes induced by functional activation of barrel cortex and olfactory bulb in mice [PDF]
, 2019 Haleh Soleimanzad +8 more
openalex +1 more source
Targeting the noradrenergic‐metabolic axis: A new strategy for sugar‐induced depression subtypes
British Journal of Pharmacology, EarlyView.Abstract Background and Purpose Lifestyle is closely related to major depressive disorder (MDD). Given the growing focus on the impact of diet on mental health, this study examined how dietary habits affect the pathophysiology of MDD. Experimental Approach Health check‐up data were analysed. Mice received sucrose under chronic unpredictable mild stress
Takatoshi Sakata +13 more
wiley +1 more source
British Journal of Pharmacology, EarlyView.Abstract Background and Purpose Pharmacological inhibition of TRPC4 and/or TRPC5 channels reduces Pavlovian aversion memory in stressed mice and reduces amygdala reactivity to aversion in humans with depression. The aims of this mouse study were to improve understanding of these anxiolytic processes, determine whether there are corrective effects on ...
Giulia Poggi +14 more
wiley +1 more source
Lateralized Odor Preference Training in Rat Pups Reveals an Enhanced Network Response in Anterior Piriform Cortex to Olfactory Input That Parallels Extended Memory [PDF]
, 2013 Christine J. Fontaine +2 more
openalex +1 more source
Top-Down Feedback Enables Flexible Coding Strategies in Olfactory Cortex
, 2022 Zhen Chen, Krishnan Padmanabhan
openalex +2 more sources