Results 221 to 230 of about 116,665 (335)

Matsupexole: A novel nonergot dopamine receptor agonist with sustained efficacy in a rat model of Parkinson's disease and limited off‐target activity

British Journal of Pharmacology, EarlyView.
Background and Purpose Dopamine receptor agonists, particularly targeting the dopamine D2L receptor (D2LR), have been used to treat Parkinson's disease (PD). However, valvular heart disease and somnolence, mainly caused by activating the serotonin 5‐HT2B receptor (5‐HT2BR) and dopamine D3 receptor (D3R), respectively, currently challenge their clinical
Takayuki Suzuki, Fumiki Oana, Masaki Oota, Yuma Handa, Osamu Kaminuma   +4 more
wiley   +1 more source

The Need to Promote Olfactory Health in Public Health Agendas Across the Globe

Clinical Otolaryngology, EarlyView.
ABSTRACT Background A good sense of smell is essential for physical and mental health, and social wellbeing; however, across the globe, regardless of the setting, national public health agendas never consider smell health. This review aims to summarise the wide‐reaching impact of smell health in public health. Methods Narrative review of the literature
Carl Martin Philpott, Thomas Hummel, Valentina Parma, Matt Lechner, Duncan Boak, Marianna Obrist   +5 more
wiley   +1 more source

Distinct information conveyed to the olfactory bulb by feedforward input from the nose and feedback from the cortex [PDF]

Joseph D. Zak, Gautam Reddy, Vaibhav Konanur, Venkatesh N. Murthy   +3 more
openalex   +1 more source

A Major Role for Intracortical Circuits in the Strength and Tuning of Odor-Evoked Excitation in Olfactory Cortex [PDF]

, 2011
Cindy Poo, Jeffry S. Isaacson
openalex   +1 more source

Top-Down Feedback Enables Flexible Coding Strategies in Olfactory Cortex

, 2022
Zhen Chen, Krishnan Padmanabhan
openalex   +2 more sources

Decision letter: Plasticity of olfactory bulb inputs mediated by dendritic NMDA-spikes in rodent piriform cortex

, 2021
Sonia Gasparini, Ian G. Davison
openalex   +1 more source

C1q neutralization during epileptogenesis attenuates complement‐mediated synaptic elimination and epileptiform activity

Epilepsia, EarlyView.
Abstract Objective Accumulating evidence indicates that aberrant C1q‐C3 complement signaling in microglia and astrocytes drives synaptic dysfunction and neuronal loss. C1q‐mediated synaptic dysfunction disrupts neuronal circuitry balance and can lead to network hyperexcitability in epilepsy.
Yoonyi Jeong, Hyun‐Kyoung Lim, Hayeon Kim, Juheon Lee, Siyoon Lee, Minah Suh   +5 more
wiley   +1 more source

Multiple cis‐regulatory elements collaborate to control mdka expression in telencephalic neural stem cells of adult zebrafish during constitutive and regenerative neurogenesis

The FEBS Journal, EarlyView.
midkine‐a (mdka), a pan‐injury response gene in vertebrates, is precisely regulated in the zebrafish telencephalon by a modular cis‐regulatory architecture. This control ensures proper expression during development, adult brain homeostasis, and regeneration.
Jincan Chen, Masanari Takamiya, Agnes Hendriks, Tanja Beil, Csilla Várnai, Nicolas Diotel, Sepand Rastegar   +6 more
wiley   +1 more source

Exposure duration and cerebral amyloidosis in the olfactory cortex of World Trade Center responders: A positron emission tomography and magnetic resonance imaging study. [PDF]

J Alzheimers Dis
Kritikos M, Zhou JW, Huang C, Gandy S, Pellecchia AC, Santiago-Michels S, Carr MA, Islam S, Yang Y, Horton MK, Lucchini RG, Franceschi AM, Bangiyev L, Vaska P, Clouston SA, Luft BJ.   +15 more
europepmc   +1 more source

The hidden science of haptics: A pedagogical review of tactile evaluation in cosmetics

International Journal of Cosmetic Science, EarlyView.
This review explores the physiological basis of tactile perception and critically examines classical and emerging sensory methods used in cosmetics, advocating for broader methodological integration and recognition of sensory analysis in the field. Abstract Sensory analysis is a cornerstone of cosmetic development, yet remains underrepresented in peer ...
Morgane Postec, Daria Terescenco, Ecaterina Gore   +2 more
wiley   +1 more source