Results 61 to 70 of about 497,866 (292)

Spared piriform cortical single-unit odor processing and odor discrimination in the Tg2576 mouse model of Alzheimer's disease. [PDF]

PLoS ONE, 2014
Alzheimer's disease is a neurodegenerative disorder that is the most common cause of dementia in the elderly today. One of the earliest reported signs of Alzheimer's disease is olfactory dysfunction, which may manifest in a variety of ways.
Wenjin Xu, Mirielle Lopez-Guzman, Chelsea Schoen, Shane Fitzgerald, Stephanie L Lauer, Ralph A Nixon, Efrat Levy, Donald A Wilson   +7 more
doaj   +1 more source

Disrupted TFEB/GDNF–cAMP/ATP Coupling Underlies Astrocytic Dysfunction and Depression in LRRK2 G2019S Parkinson's Mice

Advanced Science, EarlyView.
ABSTRACT The LRRK2 G2019S mutation, a Parkinson's disease–linked variant, has been associated with depression‐like phenotypes, but mechanisms remain unclear. We chart age‐dependent behavioral changes and astrocyte reactivity in G2019S mice and define a pathway connecting LRRK2 to TFEB/GDNF signaling, cellular energetics, and inflammation.
Longping Yao, Maryam Hatami, Sumeyye Koc, Qing Jiang, Thomas Skutella, Yuanfeng Zhang   +5 more
wiley   +1 more source

Brain Activations in Response to Prolonged Citral Inhalation Detected by Manganese-Enhanced Magnetic Resonance Imaging (MEMRI)

Chinese Journal of Magnetic Resonance, 2020
In this study, an olfactory inhalation instrument was devised to allow the rats to inhale volatile citral or odorless air. Manganese-enhanced magnetic resonance imaging (MEMRI) was used to reveal changes of accumulative brain activities after a 24 h ...
FANG Wen-heng
doaj   +1 more source

Motor Cortex Response to Pleasant Odor Perception and Imagery: The Differential Role of Personality Dimensions and Imagery Ability

Frontiers in Human Neuroscience, 2022
BackgroundNeuroimaging studies have shown a complex pattern of brain activation during perception of a pleasant odor and during its olfactory imagery. To date, little is known regarding changes in motor cortex excitability during these tasks.
Carmenrita Infortuna, Francesca Gualano, Francesca Gualano, David Freedberg, Sapan P. Patel, Asad M. Sheikh, Maria Rosaria Anna Muscatello, Antonio Bruno, Carmela Mento, Eileen Chusid, Zhiyong Han, Florian P. Thomas, Fortunato Battaglia, Fortunato Battaglia   +13 more
doaj   +1 more source

Statistical localization of human olfactory cortex

NeuroImage, 2013
Functional neuroimaging methods have been used extensively during the last decades to explore the neural substrates of olfactory processing. While a general consensus on the functional anatomy of olfactory cortex is beginning to emerge, the mechanisms behind the functions of individual processing nodes still remain debated.
Janina Seubert, Jessica Freiherr, Jelena Djordjevic, Johan N. Lundström   +3 more
openaire   +2 more sources

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing

Advanced Science, EarlyView.
Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale, Marie Celine Lefevre, Alessio Carmignani, Maria Cristina Ceccarelli, Matteo Battaglini, Attilio Marino, Gianni Ciofani   +6 more
wiley   +1 more source

Greater addition of neurons to the olfactory bulb than to the cerebral cortex of eulipotyphlans but not rodents, afrotherians or primates

Frontiers in Neuroanatomy, 2014
The olfactory bulb is an evolutionarily old structure that antedates the appearance of a six-layered mammalian cerebral cortex. As such, the neuronal scaling rules that apply to scaling the mass of the olfactory bulb as a function of its number of ...
Pedro Furtado De Mattos Ribeiro, Paul eManger, Kenneth C Catania, Jon H Kaas, Suzana eHerculano-Houzel   +4 more
doaj   +1 more source

Topological reorganization of odor representations in the olfactory bulb. [PDF]

, 2007
Odors are initially represented in the olfactory bulb (OB) by patterns of sensory input across the array of glomeruli. Although activated glomeruli are often widely distributed, glomeruli responding to stimuli sharing molecular features tend to be ...
Benjamin Judkewitz, Rainer W Friedrich, Judkewitz, Benjamin, Yaksi, E., Yaksi, Emre, Friedrich, Rainer W, Judkewitz, B., Friedrich, R., Emre Yaksi, Friedrich Rainer W, Judkewitz Benjamin, Yaksi Emre   +11 more
core   +2 more sources

Remote Magnetomechanical Neuromodulation Uncovers Therapeutic Mechanisms for Alleviating Parkinsonian Symptoms in Freely Moving Mice

Advanced Science, EarlyView.
Magnetomechanical neuromodulation using magnetic nanodiscs enables remote activation of neurons. In a hemiparkinsonian mouse model, alternating magnetic fields actuate the nanodiscs to generate torque that opens mechanosensitive ion channels within the subthalamic nucleus, thereby modulating basal ganglia motor circuitry.
Anouk Wolters, Lorenzo Signorelli, Christian Herff, Sophia Gimple, Renzo Riemens, Gunter Kenis, Kim Rijkers, Hamed Shabani, Jyh‐Jang Sun, Yasin Temel, Hans Clusmann, Danijela Gregurec, Sarah‐Anna Hescham   +12 more
wiley   +1 more source

Photonic‐Enabled Energy‐Efficient Transparent Neuromorphic Computing Devices: A Review

Advanced Science, EarlyView.
Transparent photonic neuromorphic computing devices merge optics and brain‐inspired computing to overcome von Neumann bottlenecks with ultrafast, low‐energy processing. By exploiting transparent oxides, 2D materials, phase‐change materials, and hybrid heterostructures, these platforms enable photonic synapses, memory, and logic for see‐through edge ...
Shuvaraj Ghosh, Ki‐bum Lee, Junghyeon Lee, Seunghee Cho, Malkeshkumar Patel, Hangfei Li, Yu Wen, Ye Zhou, Joondong Kim   +8 more
wiley   +1 more source