Results 101 to 110 of about 125,273 (334)

Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain

Advanced Science, EarlyView.
This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao, Lifang Guo, Guochao Yang, Chaoli Huang, He Wang, Jian‐Jun Yang, Guiquan Chen, Yimin Hu   +7 more
wiley   +1 more source

Disruption of Aedes aegypti olfactory system development through chitosan/siRNA nanoparticle targeting of semaphorin-1a. [PDF]

PLoS Neglected Tropical Diseases, 2013
Despite the devastating impact of mosquito-borne illnesses on human health, surprisingly little is known about mosquito developmental biology, including development of the olfactory system, a tissue of vector importance.
Keshava Mysore, Ellen M Flannery, Michael Tomchaney, David W Severson, Molly Duman-Scheel   +4 more
doaj   +1 more source

The Amphioxus SoxB Family: Implications for the Evolution of Vertebrate Placodes [PDF]

, 2007
Cranial placodes are regions of thickened ectoderm that give rise to sense organs and ganglia in the vertebrate head. Homologous structures are proposed to exist in urochordates, but have not been found in cephalochordates, suggesting the first chordates
Bronner-Fraser, Marianne, Meulemans, Daniel   +1 more
core   +1 more source

Extensive Copy-Number Variation of Young Genes across Stickleback Populations [PDF]

, 2014
MM received funding from the Max Planck innovation funds for this project. PGDF was supported by a Marie Curie European Reintegration Grant (proposal nr 270891). CE was supported by German Science Foundation grants (DFG, EI 841/4-1 and EI 841/6-1).
A Abyzov, A Alexa, A Conesa, A Hussain, AJ Iafrate, AJ Sharp, AJ Vilella, AR Boyko, AR Quinlan, B Guo, BE Deagle, C Eizaguirre, C Eizaguirre, Christophe Eizaguirre, CL McGrath, CL Peichel, D Bryant, D Juan, D Tautz, DE Cook, DH Huson, DJ Turner, DR Schrider, DR Schrider, DR Zerbino, E Gazave, E Proux, Erich Bornberg-Bauer, FA Kondrashov, FC Jones, Frédéric J. J. Chain, G Gibson, G Orti, GC Conant, GH Perry, GH Perry, GM Cooper, H Kehrer-Sawatzki, H Li, Irene E. Samonte, J Sebat, JA Fawcett, Jianzhi Zhang, JJ Emerson, JK Colbourne, JO Korbel, JO Korbel, K Chen, K Khalturin, K Ye, KJ Lipinski, KJ Livak, KM Teshima, KM Wegner, L Xu, LC Hsing, LR Saraiva, M Hiraiwa, M Long, M Long, M Lynch, M Lynch, M Milinski, M Roesti, MA DePristo, Mahesh Panchal, Manfred Milinski, Martin Kalbe, Monika Stoll, N Ghanem, P Danecek, P Flicek, P Sjödin, PA Hohenlohe, PGD Feulner, PH Sudmant, Philine G. D. Feulner, PM Kim, R Redon, RC Iskow, S Moretti, S Sawyer, SF Altschul, SH Williamson, SM Waszak, SR Browning, T Marques-Bonet, T Rausch, TD Schmittgen, Thorsten B. H. Reusch, Tobias L. Lenz, V Guryev, V Katju, V Katju, V Ranwez, X Huang, Y Hashiguchi, Y Hashiguchi, Y Zheng, YE Zhang, YF Chan, Z Yang   +101 more
core   +3 more sources

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Odorant receptor genes are expressed in olfactory neuroblastoma

Genetics and Molecular Research, 2013
Olfactory neuroblastoma (ONB) is a malignant tumor found in the human nasal cavity. These tumors are rare and poorly characterized at the molecular level. In this study, we asked whether olfactory-specific genes are expressed in ONBs by using reverse-transcriptase-polymerase chain reaction.
D C, Gonzalez-Kristeller, L M, Gutiyama, A H, Campos, F A, Soares, H, Brentani, B, Malnic   +5 more
openaire   +2 more sources

Genetic basis of olfactory cognition: extremely high level of DNA sequence polymorphism in promoter regions of the human olfactory receptor genes revealed using the 1000 Genomes Project dataset

Frontiers in Psychology, 2014
The molecular mechanism of olfactory cognition is very complicated. Olfactory cognition is initiated by olfactory receptor proteins (odorant receptors), which are activated by olfactory stimuli (ligands). Olfactory receptors are the initial player in the
Elena V. Ignatieva, Elena V. Ignatieva, Victor G. Levitsky, Victor G. Levitsky, Nikolay S. Yudin, Nikolay S. Yudin, Mikhail P. Moshkin, Mikhail P. Moshkin, Nikolay A. Kolchanov, Nikolay A. Kolchanov, Nikolay A. Kolchanov   +10 more
doaj   +1 more source

An Alzheimer’s Disease Patient-Derived Olfactory Stem Cell Model Identifies Gene Expression Changes Associated with Cognition [PDF]

, 2022
Laura M. Rantanen, Mainá Bitar, Riikka Lampinen, Romal Stewart, Hazel Quek, Lotta E. Oikari, Carla Cuní‐López, Ratneswary Sutharsan, Gayathri Thillaiyampalam, Jamila Iqbal, Daniel Russell, Elina Penttilä, Heikki Löppönen, Juha-Matti Lehtola, Toni Saari, Sanna Hannonen, Anne M. Koivisto, Larisa M. Haupt, Alan Mackay‐Sim, Alexandre S. Cristino, Katja M. Kanninen, Anthony R. White   +21 more
openalex   +1 more source

Intracellular Aβ42 Sequestration by a Serine Protease Mitigates Neurotoxicity in a Drosophila Alzheimer's Disease Model

Advanced Science, EarlyView.
Emerging evidence suggests that intraneuronal Aβ accumulation represents an early pathogenic event in Alzheimer's disease (AD). Using Drosophila AD model, this study shows that a nonsecreted serine protease Yip7 physically interacts with Aβ. This causes intraneuronal Aβ accumulation but surprisingly reduces the associated neurotoxicity, arguing that ...
Jingyun Su, Meng Yang, Xinfeng Wang, Pa Wu, Zongzhao Zhai   +4 more
wiley   +1 more source

Underlying Mathematics in Diversification of Human Olfactory Receptors in Different Loci [PDF]

, 2010
As per conservative estimate, approximately (51-105) Olfactory Receptors (ORs) loci are present in human genome occurring in clusters. These clusters are apparently unevenly spread as mosaics over 21 pair of human chromosomes.
Arunava Goswami, Pabitra Pal Choudhury, Sk. Sarif Hassan   +2 more
core   +1 more source