Results 111 to 120 of about 69,587 (287)

The gustatory system influences "Drosophila" lifespan [PDF]

, 2011
The lifespan of an organism is affected by the complex interplay between genetic and environmental factors. In C. elegans, this interaction between genes and environment is mediated by the sensory system.
Ostojić, Ivan
core   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Extensive Copy-Number Variation of Young Genes across Stickleback Populations [PDF]

, 2014
MM received funding from the Max Planck innovation funds for this project. PGDF was supported by a Marie Curie European Reintegration Grant (proposal nr 270891). CE was supported by German Science Foundation grants (DFG, EI 841/4-1 and EI 841/6-1).
Manfred Milinski (47828), Samonte, I., Tobias L. Lenz, Erich Bornberg-Bauer (135063), Bornberg-Bauer, E, Reusch, Thorsten B. H., Mahesh Panchal, Philine G. D. Feulner, Panchal, Mahesh, Philine G D Feulner, Samonte, IE, Feulner, P., Panchal, M., Philine G. D. Feulner (331067), Milinski, Manfred, Eizaguirre, C, Samonte, Irene E., Monika Stoll (77524), Kalbe, M., Monika Stoll, Reusch, TBH, Christophe Eizaguirre (669459), Chain, Frédéric J. J., Stoll, Monika, Irene E. Samonte (669460), Irene E Samonte, Reusch, T., Lenz, TL, Christophe Eizaguirre, Kalbe, Martin, Manfred Milinski, Panchal, M, Frédéric J. J. Chain (270412), Eizaguirre, C., Thorsten B H Reusch, Martin Kalbe, Martin Kalbe (47827), Chain, F. J. J., Chain, F., Kalbe, M, Eizaguirre, Christophe, Frédéric J. J. Chain, Lenz, T. L., Mahesh Panchal (669458), Reusch, Thorsten B.H., Thorsten B. H. Reusch (333945), Lenz, T., Stoll, M., Milinski, M, Tobias L Lenz, Feulner, Philine, Bornberg-Bauer, Erich, Irene E. Samonte, Chain, FJJ, Erich Bornberg-Bauer, Samonte, I. E., Stoll, M, Feulner, PGD, Zhang, Jianzhi, Feulner, P. G. D., Bornberg-Bauer, E., Thorsten B. H. Reusch, Frédéric J J Chain, Milinski, M., Tobias L. Lenz (669461), Lenz, Tobias L.   +65 more
core   +1 more source

S100A14 in Tumor‐Derived EVs Targets PIAS3 to Reprogram Astrocytes and Induce Immunosuppressive Microenvironment Promoting Brain Metastasis and Germacrone Reversal Effect

Advanced Science, EarlyView.
This study identifies S100A14 in tumor‐derived exosomes as a key driver of brain metastasis. S100A14 targets PIAS3 in astrocytes, activating STAT3 signaling and promoting immunosuppressive MDSCs recruitment via chemokine secretion. Germacrone, a natural compound, binds S100A14 to disrupt this axis, effectively inhibiting brain metastasis with low ...
Qian Feng, Xia Yang, Lin An, Xue‐Yu Wang, Ming‐Rui Wang, Zhuo‐Hong Cai, Cai‐Jun Xie, Li‐Jun Qiao, You‐Bi Shen, Xi‐Min Liang, Rong Zhang, Cai‐Yan Wang, Zhong‐Qiu Liu, Rong‐Rong Zhang   +13 more
wiley   +1 more source

Unravelling the Olfactory Sense: From the Gene to Odor Perception [PDF]

Chemical Senses, 2015
Although neglected by science for a long time, the olfactory sense is now the focus of a panoply of studies that bring new insights and raises interesting questions regarding its functioning. The importance in the clarification of this process is of interest for science, but also motivated by the food and perfume industries boosted by a consumer ...
Teixeira, Carla S. Silva, Cerqueira, Nuno M. F. S. A., Silva Ferreira, António César   +2 more
openaire   +3 more sources

Transcriptional Basis of Copper-Induced Olfactory Impairment in the Sea Lamprey, a Primitive Invasive Fish

G3: Genes, Genomes, Genetics, 2019
Olfaction mediates behaviors necessary for survival and reproduction in fishes. Anthropogenic inputs of contaminants into aquatic environments, specifically copper, are known to disrupt a broad range of olfactory-mediated behaviors and can cause long ...
Jenna Jones, Kyle Wellband, Barbara Zielinski, Daniel D. Heath   +3 more
doaj   +1 more source

Disruption of Aedes aegypti olfactory system development through chitosan/siRNA nanoparticle targeting of semaphorin-1a. [PDF]

PLoS Neglected Tropical Diseases, 2013
Despite the devastating impact of mosquito-borne illnesses on human health, surprisingly little is known about mosquito developmental biology, including development of the olfactory system, a tissue of vector importance.
Keshava Mysore, Ellen M Flannery, Michael Tomchaney, David W Severson, Molly Duman-Scheel   +4 more
doaj   +1 more source

mGluR5 in ECCCK to BLA Circuit Modulates Depressive‐Like Phenotypes through CCK Signaling

Advanced Science, EarlyView.
Dysregulation of mGluR5 and CCK signaling contributes to major depressive disorder, yet circuit‐level mechanisms remain unclear. Here, the ECCCK→BLA pathway is identified as a critical regulator of affective behavior. mGluR5 modulates synaptic function and CCK signaling within this circuit, controlling stress susceptibility and depressive‐like states ...
Muhammad Asim, Huajie Wang, Gao Qianqian, Abdul Waris, Jufang He   +4 more
wiley   +1 more source

Signatures of Selection in the Human Olfactory Receptor OR5I1 Gene [PDF]

Molecular Biology and Evolution, 2007
The human olfactory receptor (OR) repertoire is reduced in comparison to other mammals and to other nonhuman primates. Nonetheless, this olfactory decline opens an opportunity for evolutionary innovation and improvement. In the present study, we focus on an OR gene, OR5I1, which had previously been shown to present an excess of amino acid replacement ...
Moreno Estrada, Andrés, Casals López, Ferran, Ramírez Soriano, Anna, Oliva Miguel, Baldomero, Calafell i Majó, Francesc, Bertranpetit, Jaume, 1952-, Bosch Fusté, Elena   +6 more
openaire   +2 more sources

Astrocytic Phenotypic Switching in Posterior Piriform Cortex Orchestrates Bone Cancer Pain–Depression Comorbidity via Purinergic–Noradrenergic Signaling

Advanced Science, EarlyView.
Bone cancer pain and depression share a common origin: astrocytic A2‐to‐A1 transition in the posterior piriform cortex. This phenotypic shift disrupts the ATP–adenosine–A2AR–norepinephrine axis, simultaneously driving nociceptive and affective dysfunction.
Jiang‐Ping Liu, Jun‐Han Zhang, Zhi‐Xuan Tan, Wei‐Bing Yan, Ya‐Ru Yuan, Yao Liu, Bing‐Di Wei, Meng‐Qi Ding, Zhuo‐Min Fu, Ying Liu, An‐Qi Wang, Lin Ma, Yong‐Hong Li, Er‐Qing Chai, Chao‐Jun Wei   +14 more
wiley   +1 more source