Results 121 to 130 of about 69,587 (287)

Genetic basis of olfactory cognition: extremely high level of DNA sequence polymorphism in promoter regions of the human olfactory receptor genes revealed using the 1000 Genomes Project dataset

Frontiers in Psychology, 2014
The molecular mechanism of olfactory cognition is very complicated. Olfactory cognition is initiated by olfactory receptor proteins (odorant receptors), which are activated by olfactory stimuli (ligands). Olfactory receptors are the initial player in the
Elena V. Ignatieva, Elena V. Ignatieva, Victor G. Levitsky, Victor G. Levitsky, Nikolay S. Yudin, Nikolay S. Yudin, Mikhail P. Moshkin, Mikhail P. Moshkin, Nikolay A. Kolchanov, Nikolay A. Kolchanov, Nikolay A. Kolchanov   +10 more
doaj   +1 more source

Aedes aegypti mosquitoes exhibit decreased repellency by DEET following previous exposure. [PDF]

, 2012
DEET (N,N-Diethyl-m-toluamide) is one of the most widely used mosquito repellents. Although DEET has been shown to be extremely effective, recent studies have revealed that certain individual insects are unaffected by its presence.
Brookfield John F. Y., Field Linda M., Stanczyk, N. M., Logan, James G, John F. Y. Brookfield, Linda M Field, Brookfield, J. F. Y., Logan, J. G., Stanczyk Nina M., Linda M. Field, James G. Logan, Logan James G., Field, L. M., John F Y Brookfield, Stanczyk, Nina M, James G Logan, Brookfield, John FY, Nina M. Stanczyk, Field, Linda M, Nina M Stanczyk   +19 more
core   +1 more source

Multi‐Omics Profiling Reveals Immunomodulatory and Pro‐Regenerative Effects of a Graphene Oxide–Collagen Scaffold in Massive Rotator Cuff Tears

Advanced Science, EarlyView.
A graphene oxide/collagen scaffold is developed for chronic massive rotator cuff tear repair. The scaffold improves compressive stability, supports reparative mesenchymal differentiation, and modulates the immune microenvironment. In chronic MRCT models, it reduces muscle degeneration, enhances tendon–bone regeneration, and improves functional recovery,
Renwen Wan, Yechuan Deng, Zixin Hu, Yanwei He, Xinting Feng, Jun Ma, Yisheng Chen, Zhijie Zhao, Jie Mei, Zhiheng Lin, Wei Luo, Zhengyuan Fang, Zhufeng Hu, Kunlun Feng, Xinrong Li, Dan Wu, Bowen Han, James Hoi po Hui, Xuanyong Liu, Chen Chen, Gang Chen, Shiyi Chen, Nirong Bao, Jiajun Qiu, Zhiwen Luo   +24 more
wiley   +1 more source

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing

Advanced Science, EarlyView.
Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale, Marie Celine Lefevre, Alessio Carmignani, Maria Cristina Ceccarelli, Matteo Battaglini, Attilio Marino, Gianni Ciofani   +6 more
wiley   +1 more source

Olfactory receptor genes cooperate with protocadherin genes in human extreme obesity [PDF]

Genes & Nutrition, 2015
Worldwide, the incidence of obesity has increased dramatically over the past decades. More knowledge about the complex etiology of obesity is needed in order to find additional approaches for treatment and prevention. Investigating the exome sequencing data of 30 extremely obese subjects (BMI 45-65 kg/m(2)) shows that predicted damaging missense ...
Edwin C. M. Mariman, Radek Szklarczyk, Freek G. Bouwman, Erik E. J. G. Aller, Marleen A. van Baak, Ping Wang   +5 more
openaire   +5 more sources

A Cluster of Olfactory Receptor Genes Linked to Frugivory in Bats [PDF]

, 2014
Diversity of the mammalian olfactory receptor (OR) repertoire has been globally reshaped by niche specialization. However, little is known about the variability of the OR repertoire at a shallower evolutionary timeframe.
Alisha Goodbla, Liliana M. Dávalos, Goodbla, Alisha, Michaël Bekaert, Davalos, Liliana M, Sara Hayden, William J. Murphy, Emma C. Teeling, Bekaert, Michaël, Hayden, Sara, Teeling, Emma C, Murphy, William J   +11 more
core   +1 more source

Remote Magnetomechanical Neuromodulation Uncovers Therapeutic Mechanisms for Alleviating Parkinsonian Symptoms in Freely Moving Mice

Advanced Science, EarlyView.
Magnetomechanical neuromodulation using magnetic nanodiscs enables remote activation of neurons. In a hemiparkinsonian mouse model, alternating magnetic fields actuate the nanodiscs to generate torque that opens mechanosensitive ion channels within the subthalamic nucleus, thereby modulating basal ganglia motor circuitry.
Anouk Wolters, Lorenzo Signorelli, Christian Herff, Sophia Gimple, Renzo Riemens, Gunter Kenis, Kim Rijkers, Hamed Shabani, Jyh‐Jang Sun, Yasin Temel, Hans Clusmann, Danijela Gregurec, Sarah‐Anna Hescham   +12 more
wiley   +1 more source

Association of smoking behavior with an odorant receptor allele telomeric to the human major histocompatibility complex [PDF]

, 2008
Smoking behavior has been associated in two independent European cohorts with the most common Caucasian human leukocyte antigen (HLA) haplotype (A1-B8-DR3). We aimed to test whether polymorphic members of the two odorant receptor (OR) clusters within the
Yu CY, Volz A, Ziegler, Andreas, Horton, Roger, Uchanska-Ziegler, Barbara, Ziegler A, Sandro Carvalho Santos, P., Füst, George, Miretti, M., Santos, Pablo Sandro Carvalho, Miretti, Marcos Mateo, Yu, Chack-Yung, Uchanska-Ziegler, B., Prohászka, Z., Yu, C.-Y., Horton, R., Beck S, Volz, A., Beck, Stephan G., Miretti M, Beck, S., Volz, Armin, Prohászka, Zoltán, Santos PSC, Füst, György, Füst, G., Uchanska-Ziegler B, Ziegler, A., Horton R   +28 more
core   +1 more source

Microbial Odorant Detection Guides Drosophila Parasitoids Seeking Hosts in Fermenting Fruits

Advanced Science, EarlyView.
Yeast microbes in fermenting fruits attract both host flies and their parasitoid wasps. Female Leptopilina boulardi detect yeast‐emitted ethyl esters via two olfactory receptors, LbouOR167 and LbouOR136. A conserved residue, Leu159, is critical for binding these compounds, enabling female wasps to locate host‐rich habitats.
Yueqi Lu, Lan Pang, Wenqi Shi, Ting Feng, Zhi Dong, Yifeng Sheng, Sicong Zhou, Longtao Yu, Hao Guo, Ying Wang, Jiani Chen, Jianhua Huang   +11 more
wiley   +1 more source

Odorant receptor genes are expressed in olfactory neuroblastoma

Genetics and Molecular Research, 2013
Olfactory neuroblastoma (ONB) is a malignant tumor found in the human nasal cavity. These tumors are rare and poorly characterized at the molecular level. In this study, we asked whether olfactory-specific genes are expressed in ONBs by using reverse-transcriptase-polymerase chain reaction.
D C, Gonzalez-Kristeller, L M, Gutiyama, A H, Campos, F A, Soares, H, Brentani, B, Malnic   +5 more
openaire   +2 more sources