Results 1 to 10 of about 393,252 (329)

ACE2 downregulation in olfactory mucosa: Eosinophilic rhinosinusitis as COVID-19 protective factor? [PDF]

Allergy, 2021
Figure 1B,F) was significantly decreased in the ONE from CRSwNP. ACE2 and TMPRSS2 mRNAs were significantly decreased in the olfactory mucosa ( p < 0.05) (Figure 1G).
Marin C, Tubita V, Langdon C, Fuentes M, Rojas-Lechuga MJ, Valero A, Alobid I, Mullol J.   +7 more
europepmc   +3 more sources

Nano-in-Micro-Particles Consisting of PLGA Nanoparticles Embedded in Chitosan Microparticles via Spray-Drying Enhances Their Uptake in the Olfactory Mucosa. [PDF]

Front Pharmacol, 2021
Intranasal delivery has gained prominence since 1990, when the olfactory mucosa was recognized as the window to the brain and the central nervous system (CNS); this has enabled the direct site specific targeting of neurological diseases for the first ...
Spindler LM, Feuerhake A, Ladel S, Günday C, Flamm J, Günday-Türeli N, Türeli E, Tovar GEM, Schindowski K, Gruber-Traub C.   +9 more
europepmc   +4 more sources

Biometal Dyshomeostasis in Olfactory Mucosa of Alzheimer's Disease Patients. [PDF]

Int J Mol Sci, 2022
Olfactory function, orchestrated by the cells of the olfactory mucosa at the rooftop of the nasal cavity, is disturbed early in the pathogenesis of Alzheimer’s disease (AD).
Lampinen R, Górová V, Avesani S, Liddell JR, Penttilä E, Závodná T, Krejčík Z, Lehtola JM, Saari T, Kalapudas J, Hannonen S, Löppönen H, Topinka J, Koivisto AM, White AR, Giugno R, Kanninen KM.   +16 more
europepmc   +7 more sources

Combined Use of Chitosan and Olfactory Mucosa Mesenchymal Stem/Stromal Cells to Promote Peripheral Nerve Regeneration In Vivo. [PDF]

Stem Cells Int, 2021
Peripheral nerve injury remains a clinical challenge with severe physiological and functional consequences. Despite the existence of multiple possible therapeutic approaches, until now, there is no consensus regarding the advantages of each option or the
Alvites RD, Branquinho MV, Sousa AC, Amorim I, Magalhães R, João F, Almeida D, Amado S, Prada J, Pires I, Zen F, Raimondo S, Luís AL, Geuna S, Varejão ASP, Maurício AC.   +15 more
europepmc   +4 more sources

Secreted factors from olfactory mucosa cells expanded as free-floating spheres increase neurogenesis in olfactory bulb neurosphere cultures [PDF]

BMC Neuroscience, 2008
Background The olfactory epithelium is a neurogenic tissue comprising a population of olfactory receptor neurons that are renewed throughout adulthood by a population of stem and progenitor cells. Because of their relative accessibility compared to intra-
Caldwell Maeve A, He Xiaoling, Barraud Perrine, Franklin Robin JM   +3 more
doaj   +7 more sources

Accurate detection of pathologic α-synuclein in CSF, skin, olfactory mucosa, and urine with a uniform seeding amplification assay [PDF]

Acta Neuropathologica Communications
Currently, early diagnosis of dementia with Lewy bodies (DLB) is based on clinical criteria, which is challenging due to overlapping symptoms with other neurodegenerative diseases. Seeding amplification assays, detecting minute amounts of disease causing
Remarh Bsoul, Oskar H. McWilliam, Gunhild Waldemar, Steen G. Hasselbalch, Anja H. Simonsen, Christian von Buchwald, Magne Bech, Clara H. Pinborg, Christian K. Pedersen, Sara O. Baungaard, José Lombardía, Patrick Ejlerskov, Matilde Bongianni, Erika Bronzato, Gianluigi Zanusso, Kristian S. Frederiksen, Eva L. Lund, Aušrinė Areškevičiūtė   +17 more
doaj   +3 more sources

Visualization and Estimation of Nasal Spray Delivery to Olfactory Mucosa in an Image-Based Transparent Nasal Model. [PDF]

Pharmaceutics, 2023
Background: Nose-to-brain (N2B) drug delivery offers unique advantages over intravenous methods; however, the delivery efficiency to the olfactory region using conventional nasal devices and protocols is low.
Seifelnasr A, Si XA, Xi J.
europepmc   +2 more sources

Chronic interleukin-13 expression in mouse olfactory mucosa results in regional aneuronal epithelium. [PDF]

Int Forum Allergy Rhinol, 2023
Olfactory dysfunction is highly associated with chronic rhinosinusitis with nasal polyps (CRSwNP), and the severity of loss has been linked with biomarkers of type 2 inflammation.
Saraswathula A, Liu MM, Kulaga H, Lane AP.   +3 more
europepmc   +2 more sources

Alpha-synuclein seeds in olfactory mucosa and cerebrospinal fluid of patients with dementia with Lewy bodies. [PDF]

Brain Commun, 2021
In patients with suspected dementia with Lewy bodies, the detection of the disease-associated α-synuclein in easily accessible tissues amenable to be collected using minimally invasive procedures remains a major diagnostic challenge.
Perra D, Bongianni M, Novi G, Janes F, Bessi V, Capaldi S, Sacchetto L, Tagliapietra M, Schenone G, Morbelli S, Fiorini M, Cattaruzza T, Mazzon G, Orrù CD, Catalan M, Polverino P, Bernardini A, Pellitteri G, Valente M, Bertolotti C, Nacmias B, Maggiore G, Cavallaro T, Manganotti P, Gigli G, Monaco S, Nobili F, Zanusso G.   +27 more
europepmc   +2 more sources

Selective CNS Targeting and Distribution with a Refined Region-Specific Intranasal Delivery Technique via the Olfactory Mucosa. [PDF]

Pharmaceutics, 2021
Intranasal drug delivery is a promising approach for the delivery of drugs to the CNS, but too heterogenous, unprecise delivery methods without standardization decrease the quality of many studies in rodents.
Maigler F, Ladel S, Flamm J, Gänger S, Kurpiers B, Kiderlen S, Völk R, Hamp C, Hartung S, Spiegel S, Soleimanizadeh A, Eberle K, Hermann R, Krainer L, Pitzer C, Schindowski K.   +15 more
europepmc   +2 more sources