Results 51 to 60 of about 31,173 (261)

Nasal Drug Delivery Systems: An Overview [PDF]

, 2015
Since ancient times, drugs have been administered via the nasal route for therapeutic and recreational purposes. The interest in, and importance, of the systemic effects of drugs administered through the nasal route, have expanded over recent decades ...
Conway, Barbara R., Ghori, Muhammad U., Mahdi, Mohammed H., Smith, Alan M.   +3 more
core   +1 more source

Multipotent stem cells from adult olfactory mucosa [PDF]

Developmental Dynamics, 2005
AbstractMultipotent stem cells are thought to be responsible for the generation of new neurons in the adult brain. Neurogenesis also occurs in an accessible part of the nervous system, the olfactory mucosa. We show here that cells from human olfactory mucosa generate neurospheres that are multipotent in vitro and when transplanted into the chicken ...
Murrell, W, Feron, F, Wetzig, A, Cameron, N, Splatt, K, Bellette, B, Bianco, J, Perry, C, Lee, G, Mackay-Sim, A   +9 more
openaire   +4 more sources

High-Yield Mucosal Olfactory Ensheathing Cells Restore Loss of Function in Rat Dorsal Root Injury

Cells, 2021
In a previous study, we reported that no axons were crossing from the severed dorsal roots to the spinal cord using the rat dorsal rhizotomy paradigm. The injury caused ipsilateral deficits of forepaw function.
Kamile Minkelyte, Andrew Collins, Modinat Liadi, Ahmed Ibrahim, Daqing Li, Ying Li   +5 more
doaj   +1 more source

Drug delivery in overcoming the blood-brain barrier: role of nasal mucosal grafting [PDF]

, 2017
The blood–brain barrier (BBB) plays a fundamental role in protecting and maintaining the homeostasis of the brain. For this reason, drug delivery to the brain is much more difficult than that to other compartments of the body. In order to bypass or cross
Carafa, Maria, Di Marzio, Luisa, Hanieh, PATRIZIA NADIA, Marianecci, Carlotta, Paolino, Donatella, Rinaldi, Federica   +5 more
core   +1 more source

Olfactory neuroepithelium in the middle turbinate: is there any impact on olfaction function after lateral marsupialization for concha bullosa surgery?

Brazilian Journal of Otorhinolaryngology, 2022
Introduction: The effect of the quantity of olfactory neuroepithelium in the middle turbinate on the postoperative olfactory function for middle turbinate concha bullosa patients has not yet been evaluated. Objective: The primary aim of this study was to
Onur İsmi, Feyzi Meşe, Harun Gür, İclal Gürses, Yusuf Vayısoğlu, Kemal Görür, Cengiz Özcan   +6 more
doaj   +1 more source

Effect of acute copper sulfate exposure on olfactory responses to amino acids and pheromones in goldfish (Carassius auratus) [PDF]

, 2009
Exposure of olfactory epithelium to environmentally relevant concentrations of copper disrupts olfaction in fish. To examine the dynamics of recovery at both functional and morphological levels after acute copper exposure, unilateral exposure of ...
Baldwin D. H., Beyers D. W., Boulay N., Carreau N. D., Chen T. G., De Boeck G., De Boeck G., Dittman A., Evans R. E., Gao X. L., Graziadei G. A., Hansen A., Hansen A., Hansen J. A., Hansen J. A., Hara T. J., Hubbard P. C., Hubbard P. C., Jennings R. A., Julliard A. K., Julliard A. K., Julliard A. K., Keller J. N., Kolmakov N. N., Konzelmann S., Kotrschal K., Mangos S., Masukawa L. M., McIntyre J. K., Moran D. T., Nair A. V., Nikonov A. A., Niyogi S., Pyle G. G., Rolen S. H., Saglio P., Sandahl J. F., Sandahl J. F., Sandahl J. F., Sato Y., Saucier D., Sloman K. A., Sorensen P., Sorensen P. W., Sorensen P. W., Stacey N., Starcevic S. L., Susankova K., Tilton F., Wang R. T., Winberg S., Zippel H. P., Zippel H. P.   +52 more
core   +2 more sources

Towards a truly biomimetic olfactory microsystem: an artificial olfactory mucosa

IET Seminar on MEMS Sensors and Actuators, 2006
Today, the capability of the human olfactory system is still, in many ways, superior to that of the electronic nose. Although electronic noses are often compared with their biological counterpart, they neither mimic its neural architecture nor achieve its discriminating performance.
Covington, JA, Gardner, JW, Tan, SL, Hamilton, A, Pearce, TC   +4 more
openaire   +4 more sources

Reliable cell purification and determination of cell purity: crucial aspects of olfactory ensheathing cell transplantation for spinal cord repair

Neural Regeneration Research, 2020
Transplantation of olfactory ensheathing cells, the glia of the primary olfactory nervous system, has been trialed for spinal cord injury repair with promising but variable outcomes in animals and humans.
Ronak Reshamwala, Megha Shah, Lucy Belt, Jenny A. K. Ekberg, James A St John   +4 more
doaj   +1 more source

Long‐Term Effects of Xenotransplantation of Human Enteric Glia in an Immunocompetent Rat Model of Acute Brain Injury

Advanced Science, EarlyView.
Acute brain injuries are characterized by extensive tissue damage, resulting in debilitating deficits in patients. Despite considerable progress, cell‐based approaches have yet to identify an ideal candidate. This long‐term study explores the use of an untested cell source – human enteric glia – and a non‐invasive administration route – intranasal ...
Nina Colitti, Edwige Rice, Franck Desmoulin, Maylis Combeau, Mélissa Parny, Lorenne Robert, Etienne Buscail, Barbara Bournet, Nathalie Vergnolle, Isabelle Raymond‐Letron, Isabelle Loubinoux, Carla Cirillo   +11 more
wiley   +1 more source

Secreted factors from olfactory mucosa cells expanded as free-floating spheres increase neurogenesis in olfactory bulb neurosphere cultures. [PDF]

, 2011
BACKGROUND: The olfactory epithelium is a neurogenic tissue comprising a population of olfactory receptor neurons that are renewed throughout adulthood by a population of stem and progenitor cells.
Barraud, Perrine, Caldwell, Maeve A, Franklin, Robin Jm, He, Xiaoling   +3 more
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