Results 51 to 60 of about 134,738 (304)

A Systematic Comparison of Alpha‐Synuclein Seed Amplification Assays for Increasing Reproducibility

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Seed amplification assays (SAAs) enable ultrasensitive detection of misfolded α‐synuclein across biofluids and tissues. Yet, heterogeneity in protocols limits cross‐study comparability and clinical translation. Here, we review α‐synuclein SAA methods and their performance across various biological matrices.
Manuela Amaral‐do‐Nascimento, Daniela F. Santos, Tuane C. R. G. Vieira, Tiago F. Outeiro   +3 more
wiley   +1 more source

Neural regulation of fear based on olfactory, visual and auditory sensory systems [PDF]

BIO Web of Conferences
Fear is a ubiquitous emotion that is crucial to the survival and development of humans and animals. Mammals perceive potential dangers through various sensory systems, thereby defending against or avoiding dangers.
Zhu Yimo
doaj   +1 more source

Conservation of Olfactory Avoidance in Drosophila Species and Identification of Repellents for Drosophila suzukii. [PDF]

, 2015
Flying insects use olfaction to navigate towards fruits in complex odor environments with remarkable accuracy. Some fruits change odor profiles substantially during ripening and related species can prefer different stages.
Krause Pham, Christine, Ray, Anandasankar   +1 more
core  

Small Extracellular Vesicles from Neural Cells: Physiological and Pathological Roles, and Potential in Neurodegenerative Therapy

Advanced Healthcare Materials, EarlyView.
Neural cell–derived small extracellular vesicles (sEVs) are emerging as pivotal mediators in neurodegenerative diseases, exerting both pathogenic and therapeutic functions. This review synthesizes current evidence on how sEVs from distinct neural cell types regulate neurodegeneration, neuroprotection, biomarker discovery, and targeted drug delivery ...
Muhammad Waqas Salim, Wei Zhang, Lyndsey Collins‐Praino, Yuling Wang, Andrew Care   +4 more
wiley   +1 more source

Comprehensive connectivity of the mouse main olfactory bulb: analysis and online digital atlas

Frontiers in Neuroanatomy, 2012
We introduce the first open resource for mouse olfactory connectivity data produced as part of the Mouse Connectome Project (MCP) at UCLA. The MCP aims to assemble a whole-brain connectivity atlas for the C57Bl/6J mouse using a double coinjection ...
Houri eHintiryan, Lin eGou, Brian eZingg, Seita eYamashita, Hannah Marie Lyden, Monica Ying Song, Arleen Kaur Grewal, Xinhai eZhang, Arthur W. Toga, Hong-Wei eDong   +9 more
doaj   +1 more source

Mapping the Cerebral Organoid Landscape: A Systematic Review of Preclinical 3D Models in Neuroscience

Advanced Healthcare Materials, EarlyView.
Cerebral organoids are transforming brain research, yet the field remains fragmented. This comprehensive systematic review maps 738 studies published between 2014 and 2024 to uncover trends, gaps, and opportunities across neuroscience. Introducing OrganoidMap—an interactive, open‐access platform to explore and compare models—this work enables ...
Anna Wolfram, Vanessa Arnold, Maik Wolfram‐Schauerte, Anastassiya Moskalchuk, Caroline Trust, Marie Vontz, Mona Scheurenbrand, Vijayasarathy Sampath‐Kumar, Sogand Ahari, Carlos Romero‐Nieto, Lisa Sevenich   +10 more
wiley   +1 more source

The signal-transduction pathways of the peripheral olfactory organ and their impairment in vertebrates

Aquaculture and Fisheries
Animals rely on olfaction to detect and process invaluable chemical information about their environment. For olfaction to function, chemicals must first be detected, which leads to the activation of signal-transduction pathways at the peripheral ...
Arash Shahriari, Bouthaina Aoudi, Keith B. Tierney   +2 more
doaj   +1 more source

The Anaphase-Promoting Complex (APC) ubiquitin ligase affects chemosensory behavior in \u3cem\u3eC. elegans\u3c/em\u3e [PDF]

, 2016
The regulation of fundamental aspects of neurobiological function has been linked to the ubiquitin signaling system (USS), which regulates the degradation and activity of proteins and is catalyzed by E1, E2, and E3 enzymes. The Anaphase-Promoting Complex
Jennings, Alexandra K., Kowalski, Jennifer R., Wang, Julia   +2 more
core   +3 more sources

Nanotherapies for Atherosclerosis: Targeting, Catalysis, and Energy Transduction

Advanced Healthcare Materials, EarlyView.
Atherosclerosis management is hindered by poor drug targeting and plaque heterogeneity. Nanotechnology overcomes these barriers via three core strategies: (1) target‐engineered nanocarriers that achieve lesion‐specific precision via ligand modification, biomimetic camouflage, stimuli‐responsive release, and self‐propelling nanomotors; (2) catalytic ...
Yuqi Yang, Jingguo Qu, Tonghuan Xiao, Xinyang Han, Michael Tin‐Cheung Ying   +4 more
wiley   +1 more source

Anterior olfactory nucleus mediates parallel inter-bulbar pathways in rodents

BMC Biology
Background Interhemispheric communication of olfactory information is crucial for accurate odor perception and odor source localization in animals. However, the underlying structural basis for this communication in mammals remains poorly understood ...
Li Wang, Anan Li, Sen Jin, Yue Liu, Feilong Yu, Rafi Haddad, Fan Jia, Peng Su, Jiajia Guo, Zhijian Zhang, Qing Liu, Fuqiang Xu   +11 more
doaj   +1 more source