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2016
The guanine nucleotide protein (G protein)-coupled receptors (GPCRs) superfamily represents the largest class of membrane protein in the human genome. More than a half of all GPCRs are dedicated to interact with odorants and are termed odorant-receptors (ORs).
Simoes de Souza Fm, Gabriela Antunes
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The guanine nucleotide protein (G protein)-coupled receptors (GPCRs) superfamily represents the largest class of membrane protein in the human genome. More than a half of all GPCRs are dedicated to interact with odorants and are termed odorant-receptors (ORs).
Simoes de Souza Fm, Gabriela Antunes
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Are Olfactory Receptors Really Olfactive?
Biosemiotics, 2011Any living organism interacts with and responds specifically to environmental molecules by expressing specific olfactory receptors. This specificity will be first examined in causal terms with particular emphasis on the mechanisms controlling olfactory gene expression, cell-to-cell interactions and odor-decoding processes.
Giorgi F, MAGGIO, Roberto, Bruni LE
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Genomics of Olfactory Receptors
2009In many species, the sense of smell plays important roles in locating food, detecting predators, navigating, and communicating social information. The olfactory system has evolved complex repertoires of odor receptors (ORs) to fulfill these functions.
Stuart Firestein, Xiaohong Zhang
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Molecular biology of olfactory receptors
Essays in Biochemistry, 1998OR proteins bind odorant ligands and transmit a G-protein-mediated intracellular signal, resulting in generation of an action potential. The accumulation of DNA sequences of hundreds of OR genes provides an opportunity to predict features related to their structure, function and evolutionary diversification.
Alona Sosinsky +2 more
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Olfactory Receptor Mechanisms [PDF]
, 1988 The olfactory system displays a dramatically sensitive and selective recognition system for odorants. Animals can detect and discriminate thousands of odorants, some at ambient concentrations as low as one part per trillion (1 ppt). While numerous theories have been advanced to explain this sensitivity and selectivity (Amoore, 1982), remarkably few ...
Pamela Sklar +2 more
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Surface processes of olfactory receptors
Cell and Tissue Research, 1978The free surface morphology of olfactory receptor cells from the nasal mucosa of Cynomolgus monkeys was studied electron microscopically. The receptor cell, in addition to showing characteristic cilia, possess several branched or unbranched shorter elevations or spiny processes covered by numerous delicate lace-like filaments not previously described ...
Paul Glees, P. E. Spoerri
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Olfactory Receptor Interactions with Other Receptors
Annals of the New York Academy of Sciences, 2009Olfactory receptors expressed in heterologous cells often suffer from retention in the endoplasmic reticulum and poor trafficking to the plasma membrane. Interactions of the olfactory receptor M71 with several subtypes of adrenergic and purinergic receptors can alleviate M71 trafficking deficits in heterologous cells and allow for robust M71 plasma ...
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A nanobiosensor based on olfactory receptors
2009 3rd International Workshop on Advances in sensors and Interfaces, 2009We propose an electronic nose of new generation, i.e. a nanosensor based on the use of large biomolecules, olfactory receptors, as sensing material. Modelling, design and experiments performed for proving the concept are reported and discussed.
ALFINITO, ELEONORA +3 more
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Olfactory receptor gene expression
Seminars in Cell & Developmental Biology, 1997Recognition and discrimination of odorous molecules are determined by heptahelical G-protein-coupled receptor proteins localized primarily in the ciliary membrane of olfactory sensory neurons. The discovery of a large multigene family encoding odorant receptors allows us to approach various facets concerning the molecular basis of olfactory ...
Heinz Breer, Jörg Strotmann
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Evolution of Olfactory Receptors
2013Olfactory receptors are a specialized set of receptor cells responsible for the detection of odors. These cells are G protein-coupled receptors and expressed in the cell membranes of olfactory sensory neurons. Once a cell is activated by a ligand, it initiates a signal transduction cascade that produces a nerve impulse to the brain where odor ...
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