Results 41 to 50 of about 2,532,098 (296)
Frontiers in Molecular Neuroscience, 2020 Trace amine-associated receptors (TAARs) are a class of G-protein-coupled receptors found in mammals. While TAAR1 is expressed in several brain regions, all the other TAARs have been described mainly in the olfactory epithelium and the glomerular layer ...
S. Espinoza +13 more
semanticscholar +1 more source
Olfactory deficits in an alpha-synuclein fly model of Parkinson's disease. [PDF]
PLoS ONE, 2014 Parkinson's disease (PD) is the most common motor neurodegenerative disorder. Olfactory dysfunction is a prevalent feature of PD. It often precedes motor symptoms by several years and is used in assisting PD diagnosis. However, the cellular and molecular
Alex Y Chen +3 more
doaj +1 more source
Nature Communications, 2022 Targeted spatial transcriptomics mapped olfactory receptor mRNAs to sections of the murine olfactory bulb to generate an interactive, statistical, 3D model of glomeruli locations and identify an ultra-sensitive receptor-odorant relationship.
Kevin W. Zhu +6 more
doaj +1 more source
Cyclic nucleotide-gated channels: structural basis of ligand efficacy and allosteric modulation [PDF]
, 1997 Most working proteins, including metabolic enzymes, transcription regulators, and membrane receptors, transporters, and ion channels, share the property of allosteric coupling. The term 'allosteric' means that these proteins mediate indirect interactions
Lester, Henry A. +2 more
core +1 more source
Cooperative interactions enable singular olfactory receptor expression in mouse olfactory neurons
bioRxiv, 2017 The monogenic and monoallelic expression of only one out of > 1000 olfactory receptor (ORs) genes requires the formation of large heterochromatic chromatin domains that sequester the OR gene clusters.
K. Monahan +5 more
semanticscholar +1 more source
Nature Communications, 2017 The olfactory bulb is arranged in glomeruli defined by their olfactory receptor expression. The authors identify an olfactory receptor for fox odour, TMT, and show that activation of the glomerulus expressing that receptor in mice leads to immobility ...
Harumi Saito +13 more
doaj +1 more source
Functional Bias and Spatial Organization of Genes in Mutational Hot and Cold Regions in the Human Genome [PDF]
, 2004 The neutral mutation rate is known to vary widely along human chromosomes, leading to mutational hot and cold regions. We provide evidence that categories of functionally-related genes reside preferentially in mutationally hot or cold regions, the size ...
Chuang, Jeffrey H., Li, Hao
core +5 more sources
Expressing exogenous functional odorant receptors in cultured olfactory sensory neurons
Neural Development, 2008 Background Olfactory discrimination depends on the large numbers of odorant receptor genes and differential ligand-receptor signaling among neurons expressing different receptors.
Fomina Alla F +3 more
doaj +1 more source
Genetic variation across the human olfactory receptor repertoire alters odor perception
Proceedings of the National Academy of Sciences of the United States of America, 2017 Significance A persistent mystery in olfaction is how the combinatorial activation of a family of 400 olfactory receptors (ORs) encodes odor perception. We take advantage of the high frequency of natural OR knockouts in the human genome to tackle a major
C. Trimmer +9 more
semanticscholar +1 more source
Transplant Antennae and Host Brain Interact to Shape Odor Perceptual Space in Male Moths. [PDF]
PLoS ONE, 2016 Behavioral responses to odors rely first upon their accurate detection by peripheral sensory organs followed by subsequent processing within the brain's olfactory system and higher centers. These processes allow the animal to form a unified impression of
Seong-Gyu Lee +3 more
doaj +1 more source