An Olfactory Receptor Pseudogene whose Function emerged in Humans [PDF]
, 2007 Human olfactory receptor, hOR17-210, is identified as a pseudogene in the human genome. Experimental data has shown however, that the gene product of cloned hOR17-210 cDNA was able to bind an odorant-binding protein and is narrowly tuned for excitation ...
Catherine Ronin +6 more
core +2 more sources
Drosophila olfactory receptors as classifiers for volatiles from disparate real world applications [PDF]
, 2014 Olfactory receptors evolved to provide animals with ecologically and behaviourally relevant information. The resulting extreme sensitivity and discrimination has proven useful to humans, who have therefore co-opted some animals' sense of smell.
Amalia Z Berna +7 more
core +1 more source
Predicting the receptive range of olfactory receptors. [PDF]
PLoS Computational Biology, 2008 Although the family of genes encoding for olfactory receptors was identified more than 15 years ago, the difficulty of functionally expressing these receptors in an heterologous system has, with only some exceptions, rendered the receptive range of given
Rafi Haddad +3 more
doaj +1 more source
Influence of blood meal on the responsiveness of olfactory receptor neurons in antennal sensilla trichodea of the yellow fever mosquito, Aedes aegypti [PDF]
, 2010 In female Aedes aegypti L. mosquitoes, a blood meal induces physiological and behavioral changes. Previous studies have shown that olfactory receptor neurons (ORNs) housed in grooved peg sensilla on the antennae of Ae.
Hansson, Bill +3 more
core +1 more source
CD36 is involved in oleic acid detection by the murine olfactory system.
Frontiers in Cellular Neuroscience, 2015 Olfactory signals influence food intake in a variety of species. To maximize the chances of finding a source of calories, an animal’s preference for fatty foods and triglycerides already becomes apparent during olfactory food search behavior.
Sonja eOberland +10 more
doaj +1 more source
Requirement for Slit-1 and Robo-2 in zonal segregation of olfactory sensory neuron axons in the main olfactory bulb [PDF]
, 2007 The formation of precise stereotypic connections in sensory systems is critical for the ability to detect and process signals from the environment. In the olfactory system, olfactory sensory neurons (OSNs) project axons to spatially defined glomeruli ...
Andrews, W +4 more
core +1 more source
Computational exploration of molecular receptive fields in the olfactory bulb reveals a glomerulus-centric chemical map [PDF]
, 2020 © The Author(s) 2020. This article is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.Progress in olfactory research is currently hampered by ...
A Nagashima +50 more
core +2 more sources
Olfactory deficits in an alpha-synuclein fly model of Parkinson's disease. [PDF]
PLoS ONE, 2014 Parkinson's disease (PD) is the most common motor neurodegenerative disorder. Olfactory dysfunction is a prevalent feature of PD. It often precedes motor symptoms by several years and is used in assisting PD diagnosis. However, the cellular and molecular
Alex Y Chen +3 more
doaj +1 more source
Enhanced self-administration of the CB1 receptor agonist WIN55,212-2 in olfactory bulbectomized rats: evaluation of possible serotonergic and dopaminergic underlying mechanisms [PDF]
, 2014 Depression has been associated with drug consumption, including heavy or problematic cannabis use. According to an animal model of depression and substance use disorder comorbidity, we combined the olfactory bulbectomy (OBX) model of depression with ...
Amchova P +11 more
core +1 more source
Nature Communications, 2022 Targeted spatial transcriptomics mapped olfactory receptor mRNAs to sections of the murine olfactory bulb to generate an interactive, statistical, 3D model of glomeruli locations and identify an ultra-sensitive receptor-odorant relationship.
Kevin W. Zhu +6 more
doaj +1 more source