Results 101 to 110 of about 52,178 (292)

18β‐Glycyrrhetinic Acid and a Nano‐Liposomal Formulation Alleviate Depression‐Like Behaviors via the Microglial mTOR‐Autophagy‐NLRP3 Axis

Advanced Science, EarlyView.
Using a novel zebrafish‐based inflammatory screening strategy, we screened and identified 18β‐glycyrrhetinic acid (18β‐GA) as a promising anti‐inflammatory candidate. We uncover a microglial mTOR–autophagy–NLRP3 axis that constitutes the mechanistic core of 18β‐GA–mediated neuroprotection.
Hua Gan, Haitao Yuan, Wenjun Zhu, Xiaokang Xie, Shen Zhou, Wenzhi Hao, Xiaowei Mo, Lian Yang, Xiaojuan Li, Junshan Liu, Lijuan Deng, Jiaxu Chen   +11 more
wiley   +1 more source

Neuromodulator Dynamics Underlying Associative Learning in the Ventral Striatum's Olfactory Tubercle

Advanced Science, EarlyView.
Using fiber photometry and genetically encoded sensors, the dynamic release patterns of four neuromodulators in the olfactory tubercle (OT)—a brain region overlapping with the olfactory cortex and ventral striatum—were systematically monitored in response to external rewards and distinct reward‐associated learning processes.
Maojun Hong, Liuting Zou, Yiqing Chen, Juan Guo, Zhixiang Xu, Tong Ma, Shuaishuai Hu, Rongfeng K. Hu   +7 more
wiley   +1 more source

International Veterinary Epilepsy Task Force recommendations for systematic sampling and processing of brains from epileptic dogs and cats [PDF]

, 2015
Traditionally, histological investigations of the epileptic brain are required to identify epileptogenic brain lesions, to evaluate the impact of seizure activity, to search for mechanisms of drug-resistance and to look for comorbidities.
A Jeans, A Katelaris, A Klang, A Pakozdy, A Pakozdy, A Pitkanen, A Woznicka, Akos Pakozdy, AM Wahle, Andrea Fischer, Andrea Tipold, Clare Rusbridge, DM Kowalska, Edward E. Patterson, ES Park, Eva Wagner, F Reinoso-Suárez, Francisco Fernández-Flores, G Isoardo, H Potschka, H Urbach, Heidrun Potschka, HO Lüders, Holger A. Volk, I Blumcke, I Toyoda, IK Hwang, J O’Muircheartaigh, Jacques Penderis, JE Cavazos, JH Margerison, JN Kornegay, JY Cheong, K Baiker, K Kobow, Karen Muñana, Kaspar Matiasek, L Wang, LP Hudson, Luisa De Risio, M Fischer, M Manford, M Oehmichen, M Sasaki, M Singer, M Thom, M Thom, M Wolf, Marco Rosati, Martí Pumarola i Batlle, ME Milne, Mette Berendt, Michael Podell, MP Witter, N Shihab, PS Buckmaster, R Adamec, R Crooks, RE Adamec, RE Adamec, RM Packer, RN Auer, Robyn G. Farquhar, S Lomoio, S Schriefl, Sam Long, Simon Platt, Sofie F. M. Bhatti, SY Bando, T Kuwabara, TS Jokinen, U Seneviratne, VA Gil, Veronika M. Stein, Y Masuo, Z Ahmed   +75 more
core   +7 more sources

Olfactory training

Nihon Bika Gakkai Kaishi (Japanese Journal of Rhinology), 2022
Okutani 司会：Fumino, Kim Jin Kook, Okutani 演者：Fumino, Kim Jin Kook, Liang Kai-Li   +4 more
openaire   +1 more source

Paternal Caffeine Exposure Programs Offspring Stress Vulnerability via Sperm Dlk1‐Dio3 Imprinting‐Directed Remodeling of a Novel Neural Circuit

Advanced Science, EarlyView.
The study elucidates that paternal preconception stress can drive offspring hyperresponsivity of the stress system via hypomethylation of a specific DNA region in sperm. This key link is confirmed in a cohort of prospective fathers: the epigenetic alteration is associated with elevated stress hormone levels.
Mengxi Lu, Gaole Dai, Sen Zhu, Shuai Zhang, Tingting Wang, Yuan Meng, Fang Yang, Xiaoyi Han, Hui Wang, Hao Kou, Dan Xu   +10 more
wiley   +1 more source

Olfactory Training for Olfactory Dysfunction

Journal of Clinical Otolaryngology Head and Neck Surgery, 2022
Sung-Dong Kim, Kyu-Sup Cho
openaire   +1 more source

SpaMode: A Broadly Applicable Framework for Deciphering Spatial Multi‐Omics Using Multimodal Mixture of Disentangled Experts

Advanced Science, EarlyView.
SpaMode introduces a versatile framework for spatial multi‐omics integration across vertical, horizontal, and mosaic scenarios. By disentangling modality‐invariant and variant features through a mixture‐of‐experts mechanism, it adaptively reconfigures spatially heterogeneous signals.
Xubin Zheng, Xinlei Huang, Xiang Zhou, Dian Meng, Ziyue Qiao, Zhiyuan Yuan, Lixin Cheng   +6 more
wiley   +1 more source

Investigation Police Dog Olfactory Acuity Through: Comparing Various Dog Breeds, Previous Training Experiences and Searching Site on the Detection of Narcotics [PDF]

, 2020
Azhar F. Abdel Fattah, Heba S.A. Gharib
openalex   +1 more source

Ethical and Frugal Approaches to Animal Experimentation in Bioelectronics and Neural Engineering—An Invertebrate Renaissance?

Advanced Electronic Materials, EarlyView.
Invertebrates are the classic neuroscience models and should make a comeback. Invertebrate organisms can be a more ethical and cost‐effective way to move bioelectronics research forward more rapidly. ABSTRACT The accelerating development of bioelectronic neural interfaces has brought increased attention to ethical considerations surrounding in vivo ...
Eric Daniel Głowacki
wiley   +1 more source

Olfactory training changes electrophysiological responses at the level of the olfactory epithelium

Rhinology journal, 2018
Olfactory training (OT) has been shown to increase olfactory performance in healthy subjects and patients with post-traumatic or post-infectious olfactory loss. Morphological correlates such as olfactory bulb volume increase and gray matter changes suggest central changes in olfactory brain areas following olfactory exposure.
T, Hummel, G, Stupka, A, Haehner, S C, Poletti   +3 more
openaire   +3 more sources