Results 91 to 100 of about 52,178 (292)
Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain
Advanced Science, EarlyView.This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao +7 more
wiley +1 more source
Maximizing Participation in Olfactory Training in a Sample with Post-COVID-19 Olfactory Loss
Brain SciencesPurpose: This study aims to highlight the feasibility of an olfactory training program entirely monitored through online media in COVID-19 patients. Methods: Classic olfactory training was performed with a sample with olfactory loss due COVID-19 (n = 11).
Alice Helena Delgado-Lima +2 more
doaj +1 more source
Advanced Science, EarlyView.Emerging evidence suggests that intraneuronal Aβ accumulation represents an early pathogenic event in Alzheimer's disease (AD). Using Drosophila AD model, this study shows that a nonsecreted serine protease Yip7 physically interacts with Aβ. This causes intraneuronal Aβ accumulation but surprisingly reduces the associated neurotoxicity, arguing that ...
Jingyun Su +4 more
wiley +1 more source
Mapping New Olfactory Bulb Neurons at the Single-Cell Level Using Iron Oxide- Assisted MRI [PDF]
, 2020 Mapping New Olfactory Bulb Neurons at the Single-Cell Level Using Iron Oxide- Assisted MRI Sarah Izabel, Dept. of Biology, with Dr. Jeffrey Dupree, Dept.
Izabel, Sarah
core +1 more source
Analytical Characterization and Sensory Analysis of Distillates of Di erent Varieties of Grapes Aged by an Accelerated Method [PDF]
, 2020 The wine spirits used for the elaboration of Brandy de Jerez are mainly obtained from wines produced from the Airen type of grape, which comes from the vineyards located in the region of La Mancha (Central Spain). This entails a limitation when achieving
García Barroso, Carmelo +5 more
core +1 more source
Advanced Science, EarlyView.A zebrafish model carrying an identical human RHO S334X allele reveals two independent genetic layers shaping retinitis pigmentosa (RP) severity: a protective 3‐bp cis‐regulatory insertion that attenuates transgene expression, and a dominant trans‐acting modifier that restores a severe phenotype.
Cong Cui +9 more
wiley +1 more source
, 2006 Fear is generally considered to be an undesirable emotional state that may reduce welfare, growth and reproductive performance in animals. Fear in horses is additionally problematic, because fear reactions can cause serious injury to both horse and human.
Christensen, Janne Winther
core
Central auditory neurons have composite receptive fields [PDF]
, 2015 High-level neurons processing complex, behaviorally relevant signals are sensitive to conjunctions of features. Characterizing the receptive fields of such neurons is difficult with standard statistical tools, however, and the principles governing their ...
Gentner, T, Kozlov, A
core +1 more source
Advanced Science, EarlyView.Laser‐induced graphene (LIG) provides a scalable, laser‐direct‐written route to porous graphene architecture with tunable chemistry and defect density. Through heterojunction engineering, catalytic functionalization, and intrinsic self‐heating, LIG achieves highly sensitive and selective detection of NOX, NH3, H2, and humidity, supporting next ...
Md Abu Sayeed Biswas +6 more
wiley +1 more source
Olfactory Generalization in Detector Dogs
Animals, 2019 Generalizing to target odor variations while retaining specificity against non-targets is crucial to the success of detector dogs under working conditions.
Ariella Y. Moser +2 more
doaj +1 more source