Results 281 to 290 of about 97,181 (355)

A Meta-Analysis of the Effects of Early Life Stress on the Prefrontal Cortex Transcriptome Reveals Long-Term Downregulation of Myelin-Related Gene Expression. [PDF]

Brain Behav
Duan TQ, Hagenauer MH, Flandreau EI, Bader A, Nguyen DM, Maras PM, Lima RMS, Gyles T, Mclain C, Meaney MJ, Nestler EJ, Watson SJ, Akil H.   +12 more
europepmc   +1 more source

Complement dysregulation in human tauopathies

Brain Pathology, EarlyView.
Complement protein and activation product levels were assessed in post‐mortem frontal cortex from three distinct subtypes of Tauopathy: Corticobasal degeneration, globular glial tauopathy, and Pick's disease. Quantification of complement proteins by immunohistochemistry and ELISA showed elevation of key complement proteins (C1q) regulators (FI) and ...
Jacqui Nimmo, Samuel Keat, Louis De Muynck, B. Paul Morgan   +3 more
wiley   +1 more source

New insights into acute ischemic stroke from the perspective of spatial omics. [PDF]

Theranostics
Deng X, Zhao M, Zhang E, Wei L, Gao X, Zhang D, Huang Y.   +6 more
europepmc   +1 more source

Multi‐pronged analysis of pediatric low‐grade glioma and ganglioglioma reveals a unique tumor microenvironment associated with BRAF alterations

Brain Pathology, EarlyView.
A multi pronged analysis approach revealed distinct neoplastic populations in PA and GG. Non‐neoplastic populations in PA showed higher levels of immune mobilizing chemokines in PA compared to GG. Abstract Pediatric low‐grade gliomas (pLGG) comprise 35% of all brain tumors.
Shadi Zahedi, Kent Riemondy, Tian Liu, Andrea M. Griesinger, Andrew M. Donson, April A. Apfelbaum, Rui Fu, Julian Grandvallet Contreras, Michele Crespo, John DeSisto, Madeline M. Groat, Emil Bratbak, Adam Green, Todd C. Hankinson, Michael Handler, Rajeev Vibhakar, Nicholas Willard, Nicholas K. Foreman, Tzu Phang, Jean Mulcahy Levy   +19 more
wiley   +1 more source

Contribution of α‐synuclein cytopathologies to distinct seeding of misfolded α‐synuclein

Brain Pathology, EarlyView.
This study investigated whether brain regions with distinct predominance of α‐synuclein (αSyn) cytopathologies show different αSyn seeding patterns in multiple system atrophy (MSA) and Lewy body disease (LBD), using an interdisciplinary approach. High seeding activity is observed in regions with oligodendrocytic‐predominant αSyn pathology in MSA.
Ain Kim, Ivan Martinez‐Valbuena, Krisztina Danics, Shelley L. Forrest, Gabor G. Kovacs   +4 more
wiley   +1 more source

Role and Mechanism of Microglia in White Matter Injury Recovery in Ischemic Stroke. [PDF]

Immun Inflamm Dis
Guo YS, Shang Y, Yao J, Bi X.
europepmc   +1 more source

Integration of omics data in the diagnosis and therapy of glioblastoma

Brain Pathology, EarlyView.
Integration of omics data in the diagnosis and therapy of glioblastoma. Abstract Since the 2016 update of the WHO Classification of Tumors of the Central Nervous System, omics data have been officially integrated into the diagnostic process for glioblastoma, the most prevalent and aggressive primary malignant brain tumor in adults.
Constantin Möller, Melanie Schoof, Keith L. Ligon, Ulrich Schüller   +3 more
wiley   +1 more source

Disruption of hnRNP A2-mediated RNA dynamics by amyloid-β drives MBP increase in Alzheimer's disease. [PDF]

Cell Mol Life Sci
Gaminde-Blasco A, Senovilla-Ganzo R, Balantzategi U, Martinez-Preciado M, Capetillo-Zarate E, García-Moreno F, Matute C, Baleriola J, Alberdi E.   +8 more
europepmc   +1 more source

The physiological and pathological effects of sphingolipid metabolism and signaling in the central nervous system

Brain Pathology, EarlyView.
Sphingolipids are vital components of cell membranes. Metabolic disruptions of sphingolipids, including ceramide and sphingosine‐1‐phosphate, are linked to neurological disorders. This article summarizes the classification, structure, and metabolic processes of sphingolipids, and the physiological and pathological effects of sphingolipid metabolism and
Tian Li, Haoying He, Ejuan Zhang, Fengjiao Hu, Zhuo Wang, Jian Xu, Mengliu Zeng, Biwen Peng   +7 more
wiley   +1 more source

Patient Experience of Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease: Qualitative Patient and Clinician Interviews Informing the Development of a Conceptual Model. [PDF]

Neurol Ther
Bennett JL, Paireddy A, Cox C, Mayhew M, Stein J, Gasalla T, Tugaut B.   +6 more
europepmc   +1 more source