Results 281 to 290 of about 118,814 (348)

Dysmorphic neurons express markers of inhibitory glycinergic signaling in focal cortical dysplasia IIb

Brain Pathology, EarlyView.
Deep learning tissue mapping can guide region of interest selection for spatial transcriptomic analyses. Using this method, a transcriptional catalogue of focal cortical dysplasia type IIb was generated, revealing enrichment for markers of inhibitory glycinergic signaling in cytomegalic dysmorphic neurons.
Ameesha Paliwal, Kevin Faust, Okty Abbasi Borhani, Mugeng Liu, Lauren Omoto, Evelyn Rose Kamski‐Hennekam, Parsa Babaei Zadeh, Rifat Shahriar Sajid, Phedias Diamandis   +8 more
wiley   +1 more source

Cx47 Phosphorylation Exacerbates White Matter Damage and Kainic Acid Induced Epilepsy. [PDF]

CNS Neurosci Ther
Li Y, Lin H, Liu J, Chen J, Shen K, Chen N, Xiang S, Wang D, Xiao N, Li T.   +9 more
europepmc   +1 more source

Upregulation of sphingomyelin and ABCA8 in response to TDP‐43 pathology in amyotrophic lateral sclerosis brain

Brain Pathology, EarlyView.
Increases in sphingomyelin in response to TDP‐43 pathology in the disease‐affected motor cortex of amyotrophic lateral sclerosis (ALS) brain. Abstract Amyotrophic lateral sclerosis (ALS) is a rapidly progressing neurodegenerative disease characterized by the degeneration of motor neurons and the presence of TAR DNA‐binding protein 43 (TDP‐43 ...
Finula I. Isik, Russell Pickford, Nicolas Dzamko, Kerry‐Anne Rye, Woojin Scott Kim   +4 more
wiley   +1 more source

The mGluR5 agonist CHPG enhances human oligodendrocyte differentiation. [PDF]

Acta Neuropathol Commun
Huang Y, Geywitz C, Bandaru A, Glass IA, Birth Defects Research Laboratory, Schirmer L, Nobuta H, Dreyfus CF.   +7 more
europepmc   +1 more source

Identification of novel FGFR2::TXLNB Fusion in a polymorphous low‐grade neuroepithelial tumor of the young

Brain Pathology, EarlyView.
We report a novel FGFR2::TXLNB fusion in a child with hippocampal PLNTY. This fusion likely drives tumorigenesis via homodimerization and activation of MAPK/PI3K pathways, expanding PLNTY's molecular spectrum and suggesting a potential therapeutic target.
Sha‐Sha Hu, Tian‐Yuan Tan, Wei Yan, Bo Wang   +3 more
wiley   +1 more source

Voltage-Gated and Chemogenetic Modulation of Calcium Signaling in Oligodendrocyte Development and Synaptic Integration. [PDF]

J Neurochem
Cheli VT, Paez PM.
europepmc   +1 more source

Endothelial Netrin‐4 regulates oligodendrocyte precursor cell proliferation and differentiation via ET‐1 signaling in preterm white matter injury

Brain Pathology, EarlyView.
Our findings show early increased Netrin‐4 in mice with PWMI boosts angiogenesis and OPCs proliferation. Later, high levels hinder OPCs differentiation into mature cells, impairing myelination. It may act by stimulating ET‐1 secretion. Abstract Perinatal hypoxia–ischemia is a leading cause of preterm white matter injury (PWMI), yet mechanisms ...
Fuxing Dong, Weixing Yan, Qiqi Meng, Xueli Song, Bing Cheng, Yaping Liu, Yanan Liu, Chao Ren, Ruiqin Yao   +8 more
wiley   +1 more source

Mislocalisation of TDP-43 to the cytoplasm of either neurons or oligodendrocytes causes axonopathy and dysmyelination

Keatinge M, Juhasz SC, Shaw-McGrath T, Albayrak J, Soong D, Marshall-Phelps K, Story D, Hoodless L, Cooper J, Almeida RG, Czopka T, Hardingham G, Lyons DA, Chandran S.   +13 more
europepmc   +1 more source

Clemastine ameliorates cognitive deficits in an experimental rat model of chronic cerebral hypoperfusion. [PDF]

J Cereb Blood Flow Metab
Zong X, Huang Z, Kong F, Feng Y, Zhang Y, Zou P, Wen Lin H, Hess DC, Zhang Q.   +8 more
europepmc   +1 more source