Results 281 to 290 of about 100,602 (348)

Age‐Dependent Regulation of Hippocampal Inflammation by the Mitochondrial Translocator Protein in Mice

Aging Cell, EarlyView.
The role of mitochondrial translocator protein (TSPO) in hippocampal inflammation is age‐dependent, with TSPO deletion drastically exacerbating inflammation in aged mice, while dampening it in young mice. This TSPO–aging interaction was linked to NF‐kβ and interferon regulatory transcriptional networks. TSPO deletion exacerbated age‐dependent depletion
Kei Onn Lai, Jia Hui Wong, Nevin Tham, Lauren Fairley, Roshan Ratnakar Naik, Yulan Wang, Sarah R. Langley, Anna M. Barron   +7 more
wiley   +1 more source

Persistent increase of Nogo-A-positive cells and dynamic reduction in oligodendroglia lineage cells in white matter regions following experimental and clinical traumatic brain injury. [PDF]

J Neuropathol Exp Neurol
Ruscher K, Michalettos G, Abu Hamdeh S, Clausen F, Nolan AL, Flygt J, Özen I, Marklund N.   +7 more
europepmc   +1 more source

Cellular Senescence Is a Central Driver of Cognitive Disparities in Aging

Aging Cell, EarlyView.
The molecular underpinnings of divergent cognitive trajectories in aging remain unresolved. Using high‐resolution behavioral testing to cognitively stratify aged male mice into ‘intact’ and ‘impaired’ subgroups, we show that reactive gliosis and cellular senescence are key determinants of disparities in cognitive function with age.
Matthew P. Baier, Rojina Ranjit, Daniel B. Owen, Jenna L. Wilson, Megan A. Stiles, Anthony M. Masingale, Zachary Thomas, Anne Bredegaard, David M. Sherry, Sreemathi Logan   +9 more
wiley   +1 more source

A case of post-infectious anti-myelin oligodendrocyte glycoprotein antibody-positive optic neuritis. [PDF]

Int J Ophthalmol
Son YB, Kim KH, Choi HY, Jeon H.
europepmc   +1 more source

TLR7 Mediates HIV‐1 Tat‐Induced Cellular Senescence in Human Astrocytes

Aging Cell, EarlyView.
Once internalized into endolysosomes, HIV‐1 Tat interacts and activates TLR7, causing endolysosome damage. Such interaction between HIV‐1 Tat and TLR7 also leads to a senescence‐like phenotype in astrocytes, including cell cycle arrest, elevated levels of p21 and p16 proteins, increased SA‐β‐gal activity, and enhanced secretion of SASP factors ...
Neda Rezagholizadeh, Gaurav Datta, Wendie A. Hasler, Erica C. Nguon, Elise V. Smokey, Xuesong Chen   +5 more
wiley   +1 more source

BCAS1-positive oligodendrocytes enable efficient cortical remyelination in multiple sclerosis. [PDF]

Brain
Bergner CG, van der Meer F, Franz J, Vakrakou A, Würfel T, Nessler S, Schäfer L, Nau-Gietz C, Winkler A, Lagumersindez-Denis N, Wrzos C, Damkou IA, Sergiou C, Schultz V, Knauer C, Metz I, Bahn E, Garea Rodriguez E, Merkler D, Simons M, Stadelmann C.   +20 more
europepmc   +1 more source

Accumulation of the cyclin-dependent kinase inhibitor p27/Kip1 and the timing of oligodendrocyte differentiation

, 1997
Béatrice Durand
openalex   +2 more sources

Incorporating familial risk, lifestyle factors, and pharmacogenomic insights into personalized noncommunicable disease (NCD) reports for healthcare funder beneficiaries participating in the Open Genome Project

Annals of Human Genetics, EarlyView.
Abstract Introduction An ethics‐guided decision‐making framework was developed for applying pathology‐supported genetic testing, a multifaceted pharmacodiagnostic approach that translates population risk stratification into clinical utility. We introduce this service, supported by the Open Genome Project, which aligns with the beneficence principle in ...
Manie De Klerk, Nicole Van Der Merwe, Johny Erasmus, Lindiwe Whati, Kelebogile E. Moremi, Daniel W. Olivier, Maritha J. Kotze   +6 more
wiley   +1 more source

Del Río Hortega's insights into oligodendrocytes: recent advances in subtype characterization and functional roles in axonal support and disease. [PDF]

Front Neuroanat
López-Muguruza E, Peiró-Moreno C, Pérez-Cerdá F, Matute C, Ruiz A.   +4 more
europepmc   +1 more source

An expanded polyglutamine in ATAXIN1 results in a loss-of-function that exacerbates severity of Multiple Sclerosis in an EAE mouse model. [PDF]

J Neuroinflammation
Talukdar G, Duvick L, Yang P, O'Callaghan B, Fuchs GJ, Cvetanovic M, Orr HT.   +6 more
europepmc   +1 more source