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LPCAT1, the Enzyme Responsible for Converting LPC to PC, Promotes OPC Differentiation In Vitro. [PDF]
Shang Q+8 more
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Neurologic Clinics, 1995
Although it was initially thought to be a passive structure, the oligodendrocyte and myelin unit is now considered highly dynamic with many important functions beyond its role in myelination. Inhibitors of neurite growth can be localized to oligodendrocyte and myelin, highlighting the importance of oligodendrocytes in general CNS maintenance and in ...
JoAnne McLaurin, Voon Wee Yong
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Although it was initially thought to be a passive structure, the oligodendrocyte and myelin unit is now considered highly dynamic with many important functions beyond its role in myelination. Inhibitors of neurite growth can be localized to oligodendrocyte and myelin, highlighting the importance of oligodendrocytes in general CNS maintenance and in ...
JoAnne McLaurin, Voon Wee Yong
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Oligodendrocytic Gliomatosis Cerebri
Acta Neurochirurgica, 2000We describe a very unusual case of gliomatosis cerebri (GC) with oligodendrocytic differentiation. A 65-year-old man presented with a convulsive seizure. Magnetic resonance (MR) documented diffuse enlargement of cerebral hemispheres, brainstem, and right cerebellar hemisphere.
Tancredi, A+4 more
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Oligodendrocyte differentiation
2016In the nervous system, axons transmit information in the form of electrical impulses over long distances. The speed of impulse conduction is enhanced by myelin, a lipid-rich membrane that wraps around axons. Myelin also is required for the long-term health of axons by providing metabolic support.
B. Appel, E.S. Mathews
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Diversity of oligodendrocytes and their progenitors
Current Opinion in Neurobiology, 2017The established function of oligodendrocytes and their progenitors is to drive the cellular events of myelination, a highly diversified process necessary to match the needs of various neuronal subtypes and networks. The morphological and molecular heterogeneity of oligodendrocytes and their progenitors point to functions beyond establishing saltatory ...
Dimou, Leda, Simons, Mikael
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The Role of Oligodendrocytes and Oligodendrocyte Progenitors in cns Remyelination
1999Remyelination enables restoration of saltatory conduction and a return of normal function lost during demyelination. Unfortunately, remyelination is often incomplete in the adult human central nervous system (CNS) and this failure of remyelination is one of the main reasons for clinical deficits in demyelinating disease. An understanding of the failure
Hans S. Keirstead, William F. Blakemore
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Oligodendrocytes and Alzheimer's disease
International Journal of Neuroscience, 2015Extensive evidence has indicated that the breakdown of myelin is associated with Alzheimer's disease (AD) since the vulnerability of oligodendrocytes under Alzheimer's pathology easily induces the myelin breakdown and the loss of the myelin sheath which might be the initiating step in the changes of the earliest stage of AD prior to appearance of ...
Zhiyou Cai, Ming Xiao
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Immunobiology of the oligodendrocyte
2010INTRODUCTION Oligodendrocytes, as the myelin-producing cells of the central nervous system (CNS), are exactly what their Greek-derived name “oligodendroglia” suggests: they, alongside astrocytes, the non-neural microglia and ependymal cells, have been characterized as the “glue” that holds together the intricate apparatus of our brain.
Hans-Peter Hartung+3 more
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Regulation of oligodendrocyte development
Microscopy Research and Technique, 2001AbstractOligodendrocytes are myelinating cells in the central nervous system. Recent studies demonstrated that oligodendrocyte progenitor cells are generated from a restricted region in the ventricular zone. In the rodent spinal cord, progenitor cells appear from narrow and bilateral longitudinal columns in the ventral ventricular zone, and then ...
Kazuhiro Ikenaka+2 more
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