Results 331 to 340 of about 100,602 (348)

Calcium signalling in oligodendrocytes [PDF]

open access: possibleNeurophysiology, 1995
Generation of calcium signal in mammalian oligodendrocytes is a result of two different mechanisms, namely: (i) transmembrane calcium influx via voltage-operated calcium channels, and (ii) calcium release from IP3-sensitive internal calcium stores.
Verkhratsky, A   +2 more
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Oligodendrocyte origins

Trends in Neurosciences, 1996
In the adult vertebrate CNS, oligodendrocytes are ubiquitously distributed throughout white matter. By contrast, in the embryonic CNS, recent studies suggest that oligodendrocyte precursors arise in a discrete ventral location. Thus, local ventral environmental signals that contribute to the overall patterning of the CNS are likely to influence the ...
openaire   +2 more sources

Regulation of oligodendrocyte development

Molecular Neurobiology, 1998
Oligodendrocytes are the cells responsible for the formation of myelin in the central nervous system. Recent studies demonstrated that cells of the oligodendrocyte lineage initially arise in distinct regions of the ventricular zone during early development.
Diana M. Orentas, Robert H. Miller
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Oligodendrocytes, GRPs and MNOPs

Trends in Neurosciences, 2003
What about earlier stages? At developmental stages earlier than E16, expression of Olig1 and Olig2 is limited to a large ventral domain of the proliferating ventricular zone that is known to generate both motoneurons and oligodendrocytes. If Olig2 expression is confined to an oligodendrocyte–motoneuron precursor, then its expression should not be seen ...
Ying Liu, Mahendra S. Rao
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The oligodendrocytic junctional complex

Cell and Tissue Research, 1978
The junctional complex of oligodendrocytes was studied by means of different electron microscopical techniques. This complex is composed of the following junctional membrane formations: 1) tight junctional domains in the oligodendrocytic membrane near the some of the cells, 2) fasciae occludentes or focal tight junctions on the outer oligodendrocytic ...
R. Dermietzel   +2 more
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Expression of plasmolipin in oligodendrocytes

Journal of Neuroscience Research, 1991
AbstractPlasmolipin is a plasma membrane proteolipid which has recently been described as a component of myelin (Cochary et al.: Journal of Neurochemistry 55:602–610, 1990). The present study reports the expression and localization of plasmolipin in primary glial cultures and secondary oligooendrocyte cultures.
Itzhak Fischer   +3 more
openaire   +3 more sources

Tight junctions of oligodendrocytes

Cell and Tissue Research, 1977
Freeze-fracture replicas of the rat corpus callosum revealed prominent junctional strands in fractured cell membranes of the somata of oligodendrocytes. The junctional strands were characterized by an elaborate system of straight or slightly undulating rows of linear aggregates of particles or ridges in the P face and furrows in the E face.
Tetsuya Itagaki   +2 more
openaire   +3 more sources

Telomerase and oligodendrocyte differentiation

Journal of Neurobiology, 2001
AbstractMyelin in the mammalian central nervous system (CNS) is produced by oligodendrocytes, most of which arise from oligodendrocyte precursor cells (OPCs) during late embryonic and early postnatal development. Both external and internal cues have been implicated in regulating OPC exit from the cell cycle and differentiation into oligodendrocytes. In
Gregg L. Caporaso   +2 more
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Oligodendrocyte degeneration in AD

Neurobiology of Aging, 2004
Most would agree with a description of Alzheimer’s disease (AD) primarily as a degeneration of the cerebral cortex. As a result, much laboratory research in the past decade has focused on the cell death mechanisms of neurons. However, it may be time broaden the focus of AD research to include dysfunction of the tracts that connect cortical areas.
G.T Whitman, Carl W. Cotman
openaire   +3 more sources

The human oligodendrocyte proteome

PROTEOMICS, 2013
Myelination of the CNS is performed by oligodendrocytes (OLs), which have been implicated in brain disorders, such as multiple sclerosis and schizophrenia. We have used the human oligodendroglial cell line MO3.13 to establish an OL reference proteome database.
Takayuki Manabe   +15 more
openaire   +3 more sources

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