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Improved synthesis of oligodeoxyribonucleotides
Tetrahedron Letters, 1990AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
K.‐P. Stengele, Wolfgang Pfleiderer
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PHOSPHONOACETATE DERIVATIVES OF OLIGODEOXYRIBONUCLEOTIDES
Nucleosides and Nucleotides, 1996Abstract A deoxyribodinucleotide phosphonoacetate derivative has been prepared, separated into individual diastereomers, and incorporated into oligodeoxyribonucleotides possessing alternating phosphodiester and phosphonoacetate backbone linkages. The hybridization properties and enzymatic stabilities of these oligonucleotides have been studied.
Michael S. Reitman +3 more
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The automated synthesis of oligodeoxyribonucleotides [PDF]
Trends in Biotechnology, 1985 Abstract Progress in science is a history of the synergistic relationship between technology and theory: growth in theoretical understanding requires and initiates technological change; technological advance opens up new areas of knowledge. The history of molecular genetics is but a single illustration of this process.
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A Chemical 5′-Phosphorylation of Oligodeoxyribonucleotides
DNA, 1986To circumvent the use of T4 polynucleotide kinase and ATP for the 5'-phosphorylation of synthetic oligodeoxyribonucleotides after deprotection and purification, we have developed a new chemical phosphorylation reagent that can be used on automated DNA synthesis instruments.
Mickey S. Urdea, Thomas Horn
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Versatile synthesis of oligodeoxyribonucleotide–oligospermine conjugates
Nature Protocols, 2007A protocol for the rapid, automated synthesis of oligospermine-oligonucleotide sequences is described. To this end, a protected spermine phosphoramidite derivative was synthesized in six steps from spermine and used as the fifth synthon in an oligonucleotide synthesizer. Parameters were optimized to reach greater than 95% coupling yields.
Voirin, E., Kotera, M., Behr, J.P.
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Selective modification of cytosines in oligodeoxyribonucleotides
Bioconjugate Chemistry, 1992A single deoxycytidine residing in an oligodeoxyribonucleotide which also contains 5-methyldeoxycytidines can be selectively derivatized with various alkylamines by sodium bisulfite-catalyzed transamination. Selective transamination results because 5-methylcytosine, unlike cytosine, does not form a bisulfite adduct.
Paul S. Miller, Cynthia D. Cushman
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ChemInform Abstract: Oligodeoxyribonucleotides Synthesis. Phosphoramidite Approach [PDF]
ChemInform, 1994 AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
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Red light activated phosphothioate oligodeoxyribonucleotides
Collection Symposium Series, 2008Hairpin-structured phosphorothioate oligodeoxyribonucleotides containing a singlet oxygen-sensitive linker in the loop were prepared. These compounds do not bind complementary nucleic acids in the dark. Upon irradiation with red light in the presence of chlorine e6 the linker within these compounds is cleaved and a single-stranded ...
Andriy Mokhir +2 more
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