Results 71 to 80 of about 201,093 (287)
Spatially Tailorable Liquid Crystalline Elastomer Alignment During Digital Light Process 3D Printing
Advanced Functional Materials, EarlyView.Here, we report the fabrication of 3D printable liquid crystalline elastomer (LCE) structures with spatially tailorable alignment domains within the same layer. This work addresses the long‐standing challenge of preparing complex 3D LCE architectures with patterned functional domains to achieve nonlinear deformations. Fabrication of multi‐domains in 3D
Adam Bischoff +8 more
wiley +1 more source
Physiological modulation of BiP activity by trans-protomer engagement of the interdomain linker
eLife, 2015 DnaK/Hsp70 chaperones form oligomers of poorly understood structure and functional significance. Site-specific proteolysis and crosslinking were used to probe the architecture of oligomers formed by the endoplasmic reticulum (ER) Hsp70, BiP.
Steffen Preissler +8 more
doaj +1 more source
Overoxidation and Oligomerization of Trypanosoma cruzi Cytosolic and Mitochondrial Peroxiredoxins
Pathogens, 2023 Peroxiredoxins (Prxs) have been shown to be important enzymes for trypanosomatids, counteracting oxidative stress and promoting cell infection and intracellular survival.
María Dolores Piñeyro +4 more
doaj +1 more source
Role of Histidine‐Containing Peptoids in Accelerating the Kinetics of Calcite Growth
Advanced Functional Materials, EarlyView.Amphiphilic histidine‐containing peptoids mimic carbonic anhydrase (CA) to accelerate calcite step growth. In the presence of Zn2+, they promote the deprotonation of HCO3−, the desolvation of Ca2+, and the reorganization of interfacial hydration layers, thereby reducing the activation barrier for calcite growth.
Mingyi Zhang +5 more
wiley +1 more source
eLife, 2018 Clathrin-independent endocytosis (CIE) mediates internalization of many transmembrane proteins but the mechanisms of cargo recruitment during CIE are poorly understood.
Tatiana Sorkina +4 more
doaj +1 more source
Soluble oligomerization provides a beneficial fitness effect on destabilizing mutations. [PDF]
, 2011 Protein stability is widely recognized as a major evolutionary constraint. However, the relation between mutation-induced perturbations of protein stability and biological fitness has remained elusive.
Eugene Shakhnovich, Shimon Bershtein
core +1 more source
ASC filament formation serves as a signal amplification mechanism for inflammasomes [PDF]
, 2016 A hallmark of inflammasome activation is the ASC speck, a micrometre-sized structure formed by the inflammasome adaptor protein ASC (apoptosis-associated speck-like protein containing a CARD), which consists of a pyrin domain (PYD) and a caspase ...
Broz, Petr +4 more
core +1 more source
Advanced Functional Materials, EarlyView.This article presents a photo‐responsive nanoparticle platform that precisely triggers copper‐dependent cuproptotic cell death in (drug‐resistant) cancer cells. The system remains stable and inactive in the dark but releases cytotoxic species upon red‐light irradiation, achieving potent activity in drug‐resistant breast cancer cells.
Ricarda Zimmermann +2 more
wiley +1 more source
Both Ca2+ and Zn2+ are essential for S100A12 protein oligomerization and function [PDF]
, 2009 Background Human S100A12 is a member of the S100 family of EF-hand calcium-modulated proteins that are associated with many diseases including cancer, chronic inflammation and neurological disorders.
Moroz, Olga V. +13 more
core +2 more sources
Facilitated Oligomerization of Mycobacterial GroEL: Evidence for Phosphorylation-Mediated Oligomerization [PDF]
Journal of Bacteriology, 2009 ABSTRACT The distinctive feature of the GroES-GroEL chaperonin system in mediating protein folding lies in its ability to exist in a tetradecameric state, form a central cavity, and encapsulate the substrate via the GroES lid. However, recombinant GroELs of Mycobacterium tuberculosis are unable to act as ...
C M Santosh, Kumar +5 more
openaire +2 more sources