Results 121 to 130 of about 125,904 (241)

A Non‐Mitophagy Activity of BNIP3L/NIX in Amygdala Glutamatergic Neurons is Essential for Contextual Fear Memory Formation

Advanced Science, EarlyView.
Contextual fear conditioning induces BNIP3L‐dependent mitochondrial fission in glutamatergic neurons of the BLA, independently of mitophagy. Loss of BNIP3L elevates Drp1Ser637 phosphorylation, thereby suppressing mitochondrial fission, compromising ATP production, and attenuating excitatory synaptic transmission.
Xingxian Zhang, Xinlei Mo, Xinyu Zhou, Xiaoliang Liu, Guizhi Li, Songhui Hu, Yangyang Lu, Chenze Zhu, Jinxi Feng, Zhitong Chen, Weiwei Hu, Yihui Cui, Zhong Chen, Xiangnan Zhang   +13 more
wiley   +1 more source

Automated Assembly of Polyglucuronic Acids for Structural Explorations. [PDF]

J Am Chem Soc
Mardhekar SN, Weh D, Delbianco M, Seeberger PH.   +3 more
europepmc   +1 more source

A Modular DNAzyme for Precise Visualization and Intervention of Alternative Splicing Isoforms in Live Cells

Advanced Science, EarlyView.
A Stringent dUPlex‐activated Error Robust (SUPER) DNAzyme system enables real‐time imaging of alternative mRNA splicing (e.g., Bcl‐xL/Bcl‐xS) in living cells via target‐triggered split‐DNAzyme reassembly and dual‐color fluorescence. It also achieves mRNA‐selective knockdown through DNAzyme‐based gene regulation, serving as a versatile tool for splicing
Mengru Lin, Jiale Sun, Yuqing Mao, Yuhao Tang, Fuan Wang, Zhihong Liu, Jing Wang   +6 more
wiley   +1 more source

N, N-Dimethyl-4-Aminopyridine- and Aluminum Isopropoxide-Catalysed Ring-Opening Polymerizations of β-Butyrolactone for the Antimicrobial Oligohydroxybutyrate. [PDF]

Int J Mol Sci
Bao Q, So PK, Leung SL, Leung PH, Tao X.
europepmc   +1 more source

Chemical Upcycling of Polyphenylene Sulfide at Room Temperature

Advanced Science, EarlyView.
Poly(phenylene sulfide) (PPS) is a semi‐crystalline super engineering plastic with exceptional properties. An iron‐photocatalyzed strategy is reported for chemical upcycling of PPS plastics at room temperature using 1,2‐dichloroethane. The method demonstrates remarkable efficiency across diverse PPS resins and post‐consumer composites, even within ...
Boning Gu, Chengliang Li, Xuefeng Jiang
wiley   +1 more source

Carnosine protects human microglia against Aβ oligomers through a multimodal mechanism of action: inhibition of oxidative stress, rescue of cellular energy status, and enhancement of phagocytosis. [PDF]

Front Immunol
Privitera A, Cardaci V, Zupan MC, Di Pietro L, Carota G, Sibbitts J, Mangione R, Graziani A, Buccarello L, Bellia F, Di Pietro V, Lazzarino G, Lunte SM, Hartley MD, Caraci F, Tavazzi B, Maiani E, Amorini AM, Lazzarino G, Caruso G.   +19 more
europepmc   +1 more source

Lewis Pair‐Engineered CuMnOx as Cold‐Adapted Multinanozyme for Cooperative Hydrolytic and Oxidative Degradation of Raw Corn Stalk

Advanced Science, EarlyView.
A Lewis pair site design strategy was established to construct Cu‐doped Mn‐based amorphous nanozymes, where Mn and oxygen vacancies generate cooperative acid‐base pairs. The resulting multinanozyme integrates glycosidase‐, oxidase‐, and cold‐adapted enzyme‐mimicking activities, enabling cooperative depolymerization of cellulose and hemicellulose ...
Huile Liu, Ziyi Di, Qing Tian, Yue Zhou, Rong Yang, Zhiyi Bai, Haoyu Wang, Yao Chen, Lianbing Zhang   +8 more
wiley   +1 more source

Vinyl chloride oligomers: On the road to understand the potential toxicity of PVC nanoplastics. [PDF]

PLoS One
Quevedo E, Perez-Sanchez E, Caballero A, Martínez A.   +3 more
europepmc   +1 more source

Oil‐Coated Nanoplastics Induce Rapid Membrane Disruption and Severe Intestinal Injury

Advanced Science, EarlyView.
Oil‐rich food contact dramatically amplifies MNP release from plastic takeout containers, producing oil‐coated nanoplastics with altered surface properties and rapid membrane‐disruptive effects. These particles cause severe intestinal barrier damage and immune dysfunction in mice, and risk modeling suggests that long‐term gastrointestinal burdens may ...
Ruwen Xie, Gulimire Yilihan, Qiong Chen, Dachuan Lin, Zhen Liu, Mengyi Yuan, Yujia Wang, Haoteng Xu, Weishang Zhou, Wanxin Gong, Yueer Li, Chen Peng, Tong Yang, Peng Gao, Qing Liu, Xin‐Hua Feng, Mu Xiao, Chao Jiang   +17 more
wiley   +1 more source

Tau oligomers modulate synapse fate by eliciting progressive bipartite synapse dysregulation and synapse loss. [PDF]

Mol Neurodegener
Pareja-Navarro KA, King CD, Kauwe G, Ngwala YY, Lokitiyakul D, Wong I, Vira A, Liu Y, Chen JH, Sharma M, Navarro G, Malak O, Zhou C, Schilling B, Tracy TE.   +14 more
europepmc   +1 more source