Results 181 to 190 of about 188,463 (312)

Liquid-liquid phase-separated tau colocalizes with and stabilizes Aβ oligomers. [PDF]

Commun Chem
Jacob T, Schützmann MP, Gerhards L, Hruby L, Leprivier G, Tamgüney G, Hoyer W.   +6 more
europepmc   +1 more source

Huntingtin Aggregate‐Responsive Autophagy Gene Circuit Mitigates Disease Pathology in R6/2 Mice

Advanced Science, EarlyView.
CD98‐mediated receptor‐mediated transcytosis enables LIP‐CD98 nanocarriers to cross the blood–brain barrier and deliver ARAA to neurons. mHTT aggregates activate the 11G–NarX sensor, initiating Auto‐P and Trans‐P signaling through the VP48–NarL relay.
Jie Zhu, Xi‐xiu Xie, Lei Li, Chen Tian, Hao‐tian Wang, Xiao‐jie Wang, Xiao‐lin Yu, Gui‐feng Zhang, Rui‐tian Liu   +8 more
wiley   +1 more source

Graphene Oxide Membranes for Recovery of Catalytically Depolymerized Lignin Monomers and Oligomers. [PDF]

ChemSusChem
Yutthasaksunthorn N, Mishra DK, Han Y, Sonker M, Sinquefield SA, Simmons BA, Choudhary H, Nair S.   +7 more
europepmc   +1 more source

AARS2‐SIRT5‐Driven DLD K445 Lactylation Promotes Cuproptosis Resistance in Glioblastoma Stem Cells

Advanced Science, EarlyView.
Lactylation of DLD at K445 by AARS2 suppresses PDH complex activity and reduces DLAT lipoylation, thereby conferring cuproptosis resistance in glioblastoma stem cells. SIRT5‐mediated delactylation restores PDH function and enhances cuproptosis sensitivity.
Mingtian Ding, Haibiao Xu, Cen Liu, Yangyin Ding, Shuai Wang, Jun Yin, Tao Fu, Xiao Jiang, Yuning Chen, Hui Luo, Rui Li, Zhengxin Chen, Huibo Wang   +12 more
wiley   +1 more source

Phycocyanobilin Attenuates Oligomerized Amyloid β-Induced Neuronal Senescence Through SIRT1-Associated Mechanisms. [PDF]

Nutrients
Lai MC, Tzeng YS, Liu IM.
europepmc   +1 more source

The Cytoplasmic MicroRNA‐Production Complex Regulates MicroRNA Sorting to Extracellular Vesicles During Synaptogenesis

Advanced Science, EarlyView.
The mechanisms of microRNA cargo sorting to extracellular vesicles, important mediators of cell communication, are not fully understood. This study reveals that the microRNA‐production machinery acts as a ‘hub’ for the sorting of microRNAs to extracellular vesicles, a process regulated by dynamic organelle interactions.
Yuzhou Zeng, Selina Luhmann, Aditi Saha, Marta Orlando, Haider Sami, Timo Glatter, Anna Antoniou   +6 more
wiley   +1 more source

Decoding Biomolecular Phase Separation: From Physiological Roles to Pathological Mechanisms and Therapeutic Biomaterials Design

Advanced Science, EarlyView.
This review systematically elaborates on the mechanisms underlying physiological regulation and pathological dysregulation of biomolecular phase separation. It also summarizes advances in phase‑separation‑targeted therapeutic strategies and the design of functional biomaterials inspired by this process.
Jiawei Zhu, Jingbo Dong, Qiufang Gong, Xuejiao Song, Zhifa Shen, Chao Liang   +5 more
wiley   +1 more source

Azole γ-Peptides Helix Switching via Heterocycle Substitutions. [PDF]

Angew Chem Int Ed Engl
Chaise S, Didierjean C, Gacogne A, Fillaudeau M, Kang YK, Lebrun A, Bantignies JL, Housset D, Amblard M, Maillard LT, Legrand B.   +10 more
europepmc   +1 more source

Decoding Interfacial Polymerization Through Steady Amine Delivery and Real‐Time QCM‐D Monitoring

Advanced Science, EarlyView.
We combine steady amine delivery with in situ quartz crystal microbalance with dissipation to track interfacial polymerization in real time. The platform resolves three kinetic regimes: pre‐gelation oligomerization, post‐gelation aggregation and network growth, and diffusion‐limited film evolution.
Yu Fang, Yu‐Ren Xue, Cheng‐Ye Zhu, Hong‐Qing Liang, Zhi‐Kang Xu   +4 more
wiley   +1 more source

Impact of Lipid Composition and Synergistic Effect on Aβ42 Oligomer-Induced Changes in Membrane Conductance and Microviscosity. [PDF]

ACS Chem Neurosci
Jankaitytė E, Polita A, Sakalauskas A, Tamulytė R, Smirnovas V, Budvytyte R.   +5 more
europepmc   +1 more source