Results 71 to 80 of about 188,463 (312)

Synthesis, Structural and Biological Analysis of Organized Biomimetic Systems [PDF]

, 2010
As a part of a program for foldamer design two β-turn mimetics (3S)-amino-5-(carboxylmethyl)-2,3-dihydro-1,5-benzothiazepin-4(5H)-one or DBT and 2-aminomethyl-phenyl-acetic acid or AMPA were selected as frameworks from a molecular modeling study for ...
Lubomir, Vezenkov
core   +1 more source

Cholic Acid Derived Oligomers as Supramolecular Hosts

, 2015
Cholic acid is natural compound that exist in most mammals. Because of the facial amphiphilicity of cholic acid, various oligomers derived from cholic acid (molecular pockets, linear oligomers, cyclic oligomers) can form hydrophobic or hydrophilic ...
Zhang Jiawei, Zhu Xiaoxia
core  

Identification and characterization of a gene conferring stress resistance in Escherichia coli and cyanobacteria

FEBS Open Bio, EarlyView.
Functional screening identified PcSyn14890, a cyanobacteria‐specific protein that enhances growth and stress resistance in E. coli and Synechocystis PCC6803. Although we expected it to function as a molecular chaperone, it was unable to protect against thermal aggregation of GAPDH.
Akiyo Yamada, Takaaki Tanaka, Manaka Uehara, Keigo Nakano, Ken Morishima, Rintaro Inoue, Masaaki Sugiyama, Masafumi Yohda   +7 more
wiley   +1 more source

An Optimal Spray Device for the Nose-to-Brain Delivery of AmyP53, an Adaptive Therapeutic Peptide for Alzheimer’s and Parkinson’s Diseases

Pharmaceutics
Background: Nose-to-brain delivery offers a noninvasive route to bypass the blood–brain barrier for the treatment of neurodegenerative diseases. AmyP53 is a first-in-class adaptive 12-mer peptide that prevents the formation of neurotoxic amyloid ...
Gonçalo Farias, Henri Chahinian, Nathalie Hauchard, Dominique Brunet, Jacques Fantini, Nouara Yahi, Driss Fantini, Anaïs Aulas   +7 more
doaj   +1 more source

Long‐Lasting and Rapid‐Responsive Media for Rewritable Information Storage Based on Low‐Cost N‐Substituted Maleimides Oligomers

Macromolecular Materials and Engineering, 2020
Controllable synthesis of high‐performance materials with low‐cost is critical for the development of functional devices. Herein, a series of sequence‐controlled low‐dispersity oligomers with acid–base chromotropic capability via simple copolymerization ...
Congcong Zhai, Yipeng Sun, Lin Xu, Umair Azhar, Yabin Zhang, Chuanyong Zong, Shuxiang Zhang   +6 more
doaj   +1 more source

Beta1 subunits enable fentanyl‐induced BK channel activation and opioid regulation of cerebral artery diameter

FEBS Open Bio, EarlyView.
During the current opioid crisis, the majority of overdose deaths are attributed to ultra‐potent synthetic opioids, such as fentanyl. While fentanyl exerts its action via opioid receptors, we propose that potassium channels in the brain blood vessels may also sense fentanyl.
Shiwani Thapa, Mohammed Nooh, Akhil Geddati, Alex Dopico, Anna N. Bukiya   +4 more
wiley   +1 more source

DNA nanostructures prevent the formation of and convert toxic amyloid proteospecies into cytocompatible and biodegradable spherical complexes

Aggregate
The deposition of insoluble proteinaceous aggregates in the form of amyloid fibrils within the extracellular space of tissues is associated with numerous diseases.
Nadjib Kihal, Phuong Trang Nguyen, Ali Nazemi, Andrea A. Greschner, Marc A. Gauthier, Steve Bourgault   +5 more
doaj   +1 more source

Antisense DNA oligomers.

, 2013
Antisense DNA oligomers.
Agnieszka Gorska (482400), Mariola Dutkiewicz (7006), Agata Swiatkowska (482401), Jerzy Ciesiolka (482402)   +3 more
core   +1 more source

Analysis of Toxic Amyloid Fibril Interactions at Natively Derived Membranes by Ellipsometry [PDF]

, 2015
There is an ongoing debate regarding the culprits of cytotoxicity associated with amyloid disorders. Although small pre-fibrillar amyloid oligomers have been implicated as the primary toxic species, the fibrillar amyloid material itself can also induce ...
Smith, Rachel A. S., Xue, Wei-Feng, Blakeman Ben J. F., Blakeman, Ben J. F., Smith, David P., Benjamin Abell (769585), Rachel A S Smith, David P. Smith (131751), Benjamin Abell, Wei-Feng Xue (610029), Ben J F Blakeman, Aleksey Nabok, David P Smith, Rachel A. S. Smith (769582), Smith Rachel A. S., Xue Wei-Feng, Nabok Aleksey, Abell Benjamin, Wei-Feng Xue, Ben J. F. Blakeman (769584), Abell, Benjamin, Aleksey Nabok (769583), Smith David P., Nabok, Aleksey, Leonenko, Zoya   +24 more
core   +2 more sources

Using fluorescence fluctuation spectroscopy to quantify molecular dynamics within cells

FEBS Open Bio, EarlyView.
Microscopy techniques like fluorescence correlation spectroscopy (FCS) and number and brightness analysis (N&B) allow to quantify concentrations, diffusion rates, and oligomerization of fluorescently labeled molecules in the living cell. In this protocol the principles of how to set up these types of experiments are described including calibration ...
Mark A. Hink
wiley   +1 more source