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Therapeutic Oligonucleotides: An Outlook on Chemical Strategies to Improve Endosomal Trafficking
Cells, 2023 The potential of oligonucleotide therapeutics is undeniable as more than 15 drugs have been approved to treat various diseases in the liver, central nervous system (CNS), and muscles.
Priyanka Mangla +2 more
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The legacy of mRNA engineering: A lineup of pioneers for the Nobel Prize
Molecular Therapy: Nucleic Acids, 2022 mRNA is like Hermes, delivering the genetic code to cellular construction sites, so it has long been of interest, but only to a small group of scientists, and only demonstrating its remarkable efficacy in coronavirus disease 2019 (COVID-19) vaccines ...
Miroslaw Janowski, Anna Andrzejewska
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Molecular Therapy: Nucleic Acids, 2021 Aptamers are short, single-stranded DNA or RNA oligonucleotide molecules that function as synthetic analogs of antibodies and bind to a target molecule with high specificity.
Dmitry Morozov +18 more
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Molecular Therapy: Nucleic Acids, 2023 Tumor suppressor genes (TSGs) are frequently downregulated in cancer, leading to dysregulation of the pathways that they control. The continuum model of tumor suppression suggests that even subtle changes in TSG expression, for example, driven by ...
Georgina L. Gregory, Ian M. Copple
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RNA Drug Delivery Using Biogenic Nanovehicles for Cancer Therapy
Frontiers in Pharmacology, 2021 RNA-based therapies have been promising method for treating all kinds of diseases, and four siRNA-based drugs and two mRNA-based drugs have been approved and are on the market now. However, none of them is applied for cancer treatment.
Nuannuan Li +4 more
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The Application of Microfluidic Technologies in Aptamer Selection
Frontiers in Cell and Developmental Biology, 2021 Aptamers are sequences of single-strand oligonucleotides (DNA or RNA) with potential binding capability to specific target molecules, which are increasingly used as agents for analysis, diagnosis, and medical treatment.
Yang Liu +14 more
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Physico-chemical foundations underpinning microarray and next-generation sequencing experiments [PDF]
, 2013 Hybridization of nucleic acids on solid surfaces is a key process involved in high-throughput technologies such as microarrays and, in some cases, next-generation sequencing (NGS).
A. Buhot +70 more
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Development of a sensitive ELISA to quantify apolipoprotein CIII in nonhuman primate serum
Journal of Lipid Research, 2011 Apolipoprotein CIII (apoCIII), a major constituent of triglyceride-rich lipoprotein, has been proposed as a key contributor to hypertriglyceridemia on the basis of its inhibitory effects on lipoprotein lipase.
Yuxin Wang +4 more
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Nucleic acid amphiphiles: Synthesis, properties, and applications
Molecular Therapy: Nucleic Acids, 2023 Nucleic acid amphiphiles, referring to nucleic acids modified with large hydrophobic groups, have been widely used in programmable bioengineering. Since nucleic acids are intrinsically hydrophilic, the hydrophobic groups endow nucleic acid amphiphiles ...
Amu Gubu +5 more
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Molecular Therapy: Nucleic Acids, 2013 Lung pathology in cystic fibrosis is linked to dehydration of the airways epithelial surface which in part results from inappropriately raised sodium reabsorption through the epithelial sodium channel (ENaC).
Kenneth L Clark +23 more
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