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The 2025 Oligo Meeting in Budapest: Highlights of the 21st annual meeting of the oligonucleotide therapeutics society [PDF]
Molecular Therapy: Nucleic AcidsBruno M.D.C. Godinho, Shuling Guo
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Therapeutic Oligonucleotides: An Outlook on Chemical Strategies to Improve Endosomal Trafficking
Cells, 2023 The potential of oligonucleotide therapeutics is undeniable as more than 15 drugs have been approved to treat various diseases in the liver, central nervous system (CNS), and muscles.
Priyanka Mangla +2 more
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Molecular Therapy: Nucleic Acids, 2023 Tumor suppressor genes (TSGs) are frequently downregulated in cancer, leading to dysregulation of the pathways that they control. The continuum model of tumor suppression suggests that even subtle changes in TSG expression, for example, driven by ...
Georgina L. Gregory, Ian M. Copple
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RNA Drug Delivery Using Biogenic Nanovehicles for Cancer Therapy
Frontiers in Pharmacology, 2021 RNA-based therapies have been promising method for treating all kinds of diseases, and four siRNA-based drugs and two mRNA-based drugs have been approved and are on the market now. However, none of them is applied for cancer treatment.
Nuannuan Li +4 more
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Journal of the American Chemical Society, 2014 Here we report the preparation of poly(oligonucleotide) brush polymers and amphiphilic brush copolymers from nucleic acid monomers via graft-through polymerization. We describe the polymerization of PNA-norbornyl monomers to yield poly-PNA (poly(peptide nucleic acid)) via ring-opening metathesis polymerization (ROMP) with the initiator, (IMesH2)(C5H5N ...
James, Carrie R. +6 more
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Microarray-based ultra-high resolution discovery of genomic deletion mutations [PDF]
, 2014 BACKGROUND: Oligonucleotide microarray-based comparative genomic hybridization (CGH) offers an attractive possible route for the rapid and cost-effective genome-wide discovery of deletion mutations.
Baban, D. +8 more
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The Application of Microfluidic Technologies in Aptamer Selection
Frontiers in Cell and Developmental Biology, 2021 Aptamers are sequences of single-strand oligonucleotides (DNA or RNA) with potential binding capability to specific target molecules, which are increasingly used as agents for analysis, diagnosis, and medical treatment.
Yang Liu +14 more
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Making Oligonucleotide Conjugates and Breaking Oligonucleotides [PDF]
Nucleic Acids Symposium Series, 2007 Presented is our most recent work on synthesis and properties of oligonucleotide analogues and conjugates These include 2'-carbamoylmethyl derivatives, peptideoligonucleotide conjugates and conjugates made to combine Watson-Crick and non-Watson-Crick interactions as well as conjugates with RNA-cleaving groups.
S, Milton +4 more
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The legacy of mRNA engineering: A lineup of pioneers for the Nobel Prize
Molecular Therapy: Nucleic Acids, 2022 mRNA is like Hermes, delivering the genetic code to cellular construction sites, so it has long been of interest, but only to a small group of scientists, and only demonstrating its remarkable efficacy in coronavirus disease 2019 (COVID-19) vaccines ...
Miroslaw Janowski, Anna Andrzejewska
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Nucleic acid amphiphiles: Synthesis, properties, and applications
Molecular Therapy: Nucleic Acids, 2023 Nucleic acid amphiphiles, referring to nucleic acids modified with large hydrophobic groups, have been widely used in programmable bioengineering. Since nucleic acids are intrinsically hydrophilic, the hydrophobic groups endow nucleic acid amphiphiles ...
Amu Gubu +5 more
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