Results 1 to 10 of about 312,912 (323)
Biodynamic effects of oligonucleotides [PDF]
Bacteriological Reviews, 1967 Werner Braun, William Firshein
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Therapeutic Oligonucleotides: An Outlook on Chemical Strategies to Improve Endosomal Trafficking
Cells, 2023 The potential of oligonucleotide therapeutics is undeniable as more than 15 drugs have been approved to treat various diseases in the liver, central nervous system (CNS), and muscles.
Priyanka Mangla +2 more
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Emerging Microbes and Infections, 2021 Candida auris has arisen as an important multidrug-resistant fungus because of several nosocomial outbreaks and elevated rates of mortality. Accurate and rapid diagnosis of C.
Luis Pla +8 more
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RNA Drug Delivery Using Biogenic Nanovehicles for Cancer Therapy
Frontiers in Pharmacology, 2021 RNA-based therapies have been promising method for treating all kinds of diseases, and four siRNA-based drugs and two mRNA-based drugs have been approved and are on the market now. However, none of them is applied for cancer treatment.
Nuannuan Li +4 more
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Making Oligonucleotide Conjugates and Breaking Oligonucleotides [PDF]
Nucleic Acids Symposium Series, 2007 Presented is our most recent work on synthesis and properties of oligonucleotide analogues and conjugates These include 2'-carbamoylmethyl derivatives, peptideoligonucleotide conjugates and conjugates made to combine Watson-Crick and non-Watson-Crick interactions as well as conjugates with RNA-cleaving groups.
Esther Yeheskiely +4 more
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Modeling of nucleobase/oligonucleotide interaction with graphene and graphene oxide: the role of charging and/or oxidizing the graphene surface [PDF]
Mol. Cryst. Liq. Cryst. 2020, Vol. 697(1), 49-59, 2021 We analyze the influence of the charge and the degree of oxidation of the surface of graphene (Gr) on its interaction with cytosine and oligonucleotide r(C)10. This is a computational study involving DFT calculations and molecular dynamics simulations. It is shown that cytosine interacts stronger with graphene oxide (GO) than with Gr, while the energy ...
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Journal of the American Chemical Society, 2014 Here we report the preparation of poly(oligonucleotide) brush polymers and amphiphilic brush copolymers from nucleic acid monomers via graft-through polymerization. We describe the polymerization of PNA-norbornyl monomers to yield poly-PNA (poly(peptide nucleic acid)) via ring-opening metathesis polymerization (ROMP) with the initiator, (IMesH2)(C5H5N ...
James, Carrie R. +6 more
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The Application of Microfluidic Technologies in Aptamer Selection
Frontiers in Cell and Developmental Biology, 2021 Aptamers are sequences of single-strand oligonucleotides (DNA or RNA) with potential binding capability to specific target molecules, which are increasingly used as agents for analysis, diagnosis, and medical treatment.
Yang Liu +14 more
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Bioconjugated oligonucleotides: recent developments and thera-eutic applications [PDF]
Bioconjugate Chemistry, American Chemical Society, 2019, 30,
pp.366-383, 2020 Oligonucleotide-based agents have the potential to treat or cure almost any disease, and are one of the key therapeutic drug classes of the future. Bioconjugated oligonucleotides, a subset of this class, are emerging from basic research and being successfully translated to the clinic.
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Molecular Therapy: Nucleic Acids, 2013 Lung pathology in cystic fibrosis is linked to dehydration of the airways epithelial surface which in part results from inappropriately raised sodium reabsorption through the epithelial sodium channel (ENaC).
Kenneth L Clark +23 more
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