Results 11 to 20 of about 629,663 (337)
Making Oligonucleotide Conjugates and Breaking Oligonucleotides [PDF]
Nucleic Acids Symposium Series, 2007 Presented is our most recent work on synthesis and properties of oligonucleotide analogues and conjugates These include 2'-carbamoylmethyl derivatives, peptideoligonucleotide conjugates and conjugates made to combine Watson-Crick and non-Watson-Crick interactions as well as conjugates with RNA-cleaving groups.
Esther Yeheskiely +4 more
openaire +3 more sources
Journal of the American Chemical Society, 2014 Here we report the preparation of poly(oligonucleotide) brush polymers and amphiphilic brush copolymers from nucleic acid monomers via graft-through polymerization. We describe the polymerization of PNA-norbornyl monomers to yield poly-PNA (poly(peptide nucleic acid)) via ring-opening metathesis polymerization (ROMP) with the initiator, (IMesH2)(C5H5N ...
James, Carrie R. +6 more
openaire +2 more sources
Emerging Microbes and Infections, 2021 Candida auris has arisen as an important multidrug-resistant fungus because of several nosocomial outbreaks and elevated rates of mortality. Accurate and rapid diagnosis of C.
Luis Pla +8 more
doaj +1 more source
Microarray-based ultra-high resolution discovery of genomic deletion mutations [PDF]
, 2014 BACKGROUND: Oligonucleotide microarray-based comparative genomic hybridization (CGH) offers an attractive possible route for the rapid and cost-effective genome-wide discovery of deletion mutations.
Baban, D. +8 more
core +3 more sources
Molecular Therapy: Nucleic Acids, 2012 Small noncoding RNAs (ncRNAs) have been shown to guide epigenetic silencing complexes to target loci in human cells. When targeted to gene promoters, these small RNAs can lead to long-term stable epigenetic silencing of gene transcription. To date, small
Stuart Knowling +6 more
doaj +1 more source
BioTech, 2023 The demand for data storage is growing at an unprecedented rate, and current methods are not sufficient to accommodate such rapid growth due to their cost, space requirements, and energy consumption.
Tomasz Buko +2 more
doaj +1 more source
Polymer–Colloid Complexes Based on Cationic Imidazolium Amphiphile, Polyacrylic Acid and DNA Decamer
Molecules, 2021 The solution behavior and physicochemical characteristics of polymer–colloid complexes based on cationic imidazolium amphiphile with a dodecyl tail (IA-12) and polyacrylic acid (PAA) or DNA decamer (oligonucleotide) were evaluated using tensiometry ...
Darya A. Kuznetsova +10 more
doaj +1 more source
Investigating synthetic oligonucleotide targeting of miR31 in Duchenne muscular dystrophy [PDF]
, 2016 Exon-skipping via synthetic antisense oligonucleotides represents one of the most promising potential therapies for Duchenne muscular dystrophy (DMD), yet this approach is highly sequence-specific and thus each oligonucleotide is of benefit to only a ...
Hildyard, J C W, Wells, D J
core +1 more source
Delivery of Gold Nanoparticles Inside Carbon Nanotubes by Oligonucleotides
Nano Biomedicine and Engineering, 2011 Delivery of gold nanoparticles with 2 nm or so in diameter inside multiwall carbon nanotubes (MCNTs) by oligonucleotides was performed under the condition of 400 k and 3 bar for 20 min.
Daxiang Cui +3 more
doaj +1 more source
Site-Specific Radioiodination of Oligonucleotides with a Phenolic Element in a Programmable Approach
Molecules, 2022 Radioiodination of oligonucleotides provides an extra modality for nucleic acid-based theranostics with potential applications. Herein, we report the design and synthesis of a phosphoramidite embedded with a phenolic moiety and demonstrate that ...
Haitao Zhao +10 more
doaj +1 more source