Results 101 to 110 of about 130,578 (251)

Structural and functional-annotation of an equine whole genome oligoarray

BMC Bioinformatics, 2009
Background The horse genome is sequenced, allowing equine researchers to use high-throughput functional genomics platforms such as microarrays; next-generation sequencing for gene expression and proteomics.
Chowdhary Bhanu, Burgess Shane C, Bright Lauren A, Swiderski Cyprianna E, McCarthy Fiona M   +4 more
doaj   +1 more source

Carcinoma de mama: novos conceitos na classificação Breast cancer: new concepts in classification

Revista Brasileira de Ginecologia e Obstetrícia, 2008
O carcinoma de mama é a neoplasia maligna mais comum em mulheres. Estudos moleculares do carcinoma de mama, baseados na identificação do perfil de expressão gênica por meio do cDNA microarray, permitiram definir pelo menos cinco sub-grupos distintos ...
Daniella Serafin Couto Vieira, Rozany Mucha Dufloth, Fernando Carlos Lander Schmitt, Luiz Carlos Zeferino   +3 more
doaj   +1 more source

Aptamer‐Engineered Ellipsometry for Clinical Detection of BALF‐Derived Exosomes: Multi‐Level Engineering for Prognostic Evaluation of Immunotherapy Responses

Advanced Science, EarlyView.
A novel ellipsometry platform functionalized with truncated PD‐L1 aptamers are developed to enable ultrasensitive detection of BALF‐derived exosomes. Through chemical ligand tailoring, mechanical sensing optimization, and tumor‐proximal fluid sampling, the system precisely stratifies ICI responders and non‐responders, offering superior sensitivity and ...
Euna Jeong, Jung Hyun Choi, Minyoung Lee, Jun Hyeok Lim, Seokho Jung, Yeeun Woo, Joo‐young Kim, Jaehyeon Ok, Lucia Kim, Woo‐jin Jeong, Won Chegal, Hyun Mo Cho, Chulhwan Park, Jiyoon Bu, Dong Hyung Kim, Taek Lee   +15 more
wiley   +1 more source

SLPI⁺ AT2‐Like Cells Orchestrate Lung Adenocarcinoma Invasion via Wnt Pathway Activation and Stromal Crosstalk in a Spatially Defined Margin Niche

Advanced Science, EarlyView.
Integrating spatial transcriptomics and single‐cell RNA sequencing, this study identifies a novel subpopulation of SLPI⁺ AT2‐like cells at the invasive margin of lung adenocarcinoma (LUAD). These cells, through stromal crosstalk and Wnt pathway activation, promote tumor stemness and invasion.
Zhoufeng Wang, Guonian Zhu, Pan Tang, Yan Wang, Wenxin Luo, Wenpeng Song, Zhikang Pan, Bingjie Zheng, YongChao Jiang, Defu Xiao, Xin Jin, Yong Bai, Guowei Che, Weimin Li   +13 more
wiley   +1 more source

Aptamer Engineering: Strategies for Discovering Functional Nucleic Acids for Next‐Generation Diagnostics and Biosensing

Advanced Science, EarlyView.
The advent of aptamers has highlighted their potential as alternatives to antibodies, overcoming limitations of structural instability and production cost. However, conventional approaches such as SELEX remain slow and labor‐intensive. This review examines recent advances in aptamer engineering, emphasizing in vitro and AI‐driven in silico strategies ...
John V. L. Nguyen, Ahlem Meziadi, Cyrill Brunner, Maureen McKeague, Lidija Malic, Maryam Tabrizian   +5 more
wiley   +1 more source

Software and methods for oligonucleotide and cDNA array data analysis. [PDF]

, 2002
Two HTML-based programs were developed to analyze and filter gene-expression data: 'Bullfrog' for Affymetrix oligonucleotide arrays and 'Spot' for custom cDNA arrays. The programs provide intuitive data-filtering tools through an easy-to-use interface. A
Barlow, Carrolee, Garcia, Anthony J, Lockhart, Daniel J, Lockhart, David J, Pankratz, Daniel G, Zapala, Matthew A   +5 more
core   +1 more source

Quantitative Assessment of Randomized DNA Base Sequences Using Multi‐Model Physical Analysis for High‐Fidelity Data Storage

Advanced Science, EarlyView.
This study quantitatively evaluates randomized DNA sequence design for digital data storage using three physics‐based models. By applying encoding schemes with strict homopolymer constraints, the framework improves base randomness, GC balance, and error resilience. Experimental validation via PCR and Sanger sequencing confirms 95–98% decoding accuracy,
Seongjun Seo, Thi Hong Nhung Vu, Anshula Tandon, Suyoun Park, Thi Bich Ngoc Nguyen, Shinsuke Kawai, Sung Ha Park   +6 more
wiley   +1 more source

A Sirtuin‐1‐Targeted Gene‐Activating Tetrahedral DNA Attenuates Bladder Fibrosis by Restoring Mitophagy in Fibroblasts via the SIRT1‐FOXO3‐BNIP3 Axis

Advanced Science, EarlyView.
The SIRT1‐targeted saRNA‐delivering tetrahedral DNA (TSA) treatment effectively upregulates SIRT1 expression, which subsequently promotes FOXO3A deacetylation. This deacetylation event relieves FOXO3A's transcriptional repression on the BNIP3 gene, thereby initiating PINK1‐PARKIN‐dependent mitophagy.
Wei Wang, Ran Yan, Lede Lin, Lei Xiang, Xiaozhi Xia, Liao Peng, Xiaoshuai Gao, Jiawei Chen, Yang Xiong, Liang Zhou, Yunfeng Lin   +10 more
wiley   +1 more source

Translational Oncogenomics and Human Cancer Interactome Networks [PDF]

, 2011
An overview of translational, human oncogenomics, transcriptomics and cancer interactomic networks is presented together with basic concepts and potential, new applications to Oncology and Integrative Cancer Biology.
I. C. Baianu
core   +1 more source

Implantable Drug Delivery Systems for Skeletal Muscles and Eyes

Advanced NanoBiomed Research, EarlyView.
This review highlights the different types of recent implantable drug delivery systems (IDDS) fabricated for a use with skeletal muscles, and with eyes. It presents the developments already made and the current research directions, showing the evolution of IDDS and their great diversity.
Serge Ostrovidov, Murugan Ramalingam, Hongkai Wu, Toshinori Fujie, Yukinari Nakamura, Takeshi Hori, Yuji Nashimoto, Xuetao Shi, Hirokazu Kaji   +8 more
wiley   +1 more source