Results 161 to 170 of about 708,274 (274)

General Platform for Efficient and Modular Assembly of GalNAc-siRNA Conjugates via Primary Amines and <i>o</i>-Nitrobenzyl Alcohol Cyclization Photoclick Chemistry Enabling Rapid Access to Therapeutic Oligonucleotides. [PDF]

JACS Au
Nie HJ, Hu H, Qi X, Zhou YJ, Liu L, Chen XH.   +5 more
europepmc   +1 more source

Native and Engineered Extracellular Vesicles for the Treatment of Acute Lung Injury and Acute Respiratory Distress Syndrome

Small Science, EarlyView.
Both native and engineered extracellular vesicles (EVs) are served as promising therapeutic agents for treating acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). To circumvent the limitations of native EVs, various engineering strategies are adopted.
Zhengyan Gu, Wenjun Xue, Guanchao Mao, Zhipeng Pei, Jingjing Li, Mingxue Sun, Xinkang Zhang, Shanshan Zhang, Songling Li, Jinfeng Cen, Kai Xiao, Ying Lu, Qingqiang Xu   +12 more
wiley   +1 more source

Scalable acoustic virtual stirrer for enhanced interfacial enzymatic nucleic acid reactions. [PDF]

Sci Adv
Li D, Li K, Li J, Li D, Chen H, Li SS, Yang C, Zhang H, Chen LJ, Hu X.   +9 more
europepmc   +1 more source

Recent Advances in Biosensors Based on Hybridization Chain Reaction and Silver Nanoclusters

Small Methods, EarlyView.
This review explores the integration of hybridization chain reaction (HCR) with silver nanoclusters (AgNCs) to form hybrid HCR‐AgNCs biosensors, highlighting advancements in their design, performance, and practical applications. It covers recent innovations, methodological improvements, and the potential of HCR‐AgNCs systems as detectors across various
Zheng Wei Wong, Siu Yee New
wiley   +1 more source

Heterodisomy in the <i>GNAS</i> locus is also a cause of pseudohypoparathyroidism type 1B (iPPSD3). [PDF]

Front Endocrinol (Lausanne)
Manero-Azua A, Vado Y, Gonzàlez Morlà J, Mogas E, Pereda A, Perez de Nanclares G.   +5 more
europepmc   +1 more source

Toward Automated DNA Nanoprinting: Advancing the Synthesis of Covalently Branched DNA

Small Methods, EarlyView.
A streamlined synthesis method for covalently branched DNA is developed, laying the foundation for future automated DNA printing devices. Different DNA strands can be covalently transferred to various small molecules, including aromatics and functional porphyrins.
Fangzhou Zhao, Daniel Saliba, Jathavan Asohan, Hanadi F. Sleiman   +3 more
wiley   +1 more source

A universal DNA microarray for rapid fish species authentication. [PDF]

Food Chem (Oxf)
Bade P, Stix S, Kappel K, Fritsche J, Haase I, Torda A, Wax N, Fischer M, Brandis D, Schröder U.   +9 more
europepmc   +1 more source

Exosome‐Based Theranostic for Gastrointestinal Cancer: Advances in Biomarker Discovery and Therapeutic Engineering

Small Methods, EarlyView.
This review explores the dual roles of exosomes in gastrointestinal (GI) cancers as diagnostic biomarkers and therapeutic agents. It highlights advancements in exosomal miRNAs, lncRNAs, circRNAs, and proteins for cancer detection and prognosis. The study also examines engineering strategies for exosome‐based drug delivery systems, their potential to ...
Mohit J. Mehta, Dongjun Shin, Hyun Sung Park, Jun Su An, Seong Il Lim, Hyun Jin Kim, Seungpyo Hong, Jiyoon Bu   +7 more
wiley   +1 more source

Case-based learning: a case of maturity-onset diabetes of the young 5 (MODY5) due to 17q12 microdeletion with a diminished plasma glucagon level. [PDF]

Diabetol Int
Sugano Y, Sekiya M, Murayama Y, Osaki Y, Iwasaki H, Suzuki H, Fukushima H, Suzuki H, Noguchi E, Shimano H.   +9 more
europepmc   +1 more source

Tethered Catalytic Hairpin Assembly with Plasmon‐Enhanced Fluorescence Readout for Single Molecule Detection

Small Methods, EarlyView.
This work presents a single‐molecule detection platform that does not rely on the partitioning of analyzed liquid samples and on enzymatic amplification of fluorescence signals. A flexible polymer linker serves to spatially confine catalytic‐harpin assembly‐based DNA amplification.
Naoto Asai, Katharina Schmidt, Gizem Aktuğ, Stefan Fossati, Juraj Sladek, N. Scott Lynn Jr., Jakub Dostalek   +6 more
wiley   +1 more source