Results 11 to 20 of about 79,402 (200)

Identification of copy neutral loss of heterozygosity on chromosomes 1p, 1q, and 6p among nonsyndromic cleft lip and/or without cleft palate with hypodontia

BMC Oral Health, 2023
Background Nonsyndromic cleft lip and/or without cleft palate (NSCL/P) with or without hypodontia is a common developmental aberration in humans and animals.
Norliana Ghazali, Normastura Abd Rahman, Thirumulu Ponnuraj Kannan, Azlina Ahmad, Sarina Sulong   +4 more
doaj   +1 more source

Evaluation of micropillar array columns for chromatographic separation of phosphorothioated oligonucleotides and their diastereomers

Analytical Science Advances, 2021
Chromatographic analysis of therapeutic oligonucleotides is challenging due to the presence of closely related impurities, degradants or metabolites and due to the presence of phosphorothioate bonds, which introduce chiral centers.
Lieve Dillen, Tiny Deschrijver, Kurt Van Mol, Jeff Op de Beeck, Paul Jacobs, Filip Cuyckens   +5 more
doaj   +1 more source

Expresión específica de los genes de la respuesta inflamatoria en subpoblaciones de macrófagos.

Biomédica: revista del Instituto Nacional de Salud, 2005
Como brazo efectivo de la respuesta inmune, los macrófagos reconocen, fagocitan y destruyen patógenos potenciales. También, coordinan respuestas adicionales del hospedero mediante la síntesis de un amplio rango de mediadores de la inflamación que, en ...
Vera María Ripoll, David Hume, Marta Raquel Fontanilla   +2 more
doaj   +1 more source

Analysis of oligonucleotide array experiments with repeated measures using mixed models

BMC Bioinformatics, 2004
Background Two or more factor mixed factorial experiments are becoming increasingly common in microarray data analysis. In this case study, the two factors are presence (Patients with Alzheimer's disease) or absence (Control) of the disease, and brain ...
Getchell Thomas V, Wood Constance L, Li Hao, Getchell Marilyn L, Stromberg Arnold J   +4 more
doaj   +1 more source

Microarray generation of thousand-member oligonucleotide libraries. [PDF]

PLoS ONE, 2011
The ability to efficiently and economically generate libraries of defined pieces of DNA would have a myriad of applications, not least in the area of defined or directed sequencing and synthetic biology, but also in applications associated with encoding ...
Nina Svensen, Juan José Díaz-Mochón, Mark Bradley   +2 more
doaj   +1 more source

Experimental optimization of probe length to increase the sequence specificity of high-density oligonucleotide microarrays

BMC Genomics, 2007
Background High-density oligonucleotide arrays are widely used for analysis of genome-wide expression and genetic variation. Affymetrix GeneChips – common high-density oligonucleotide arrays – contain perfect match (PM) and mismatch (MM) probes generated
Kashiwagi Akiko, Furusawa Chikara, Ono Naoaki, Suzuki Shingo, Yomo Tetsuya   +4 more
doaj   +1 more source

Microarrays and infectious diseases: overview and perspectives [PDF]

Einstein (São Paulo), 2005
Disease investigation is evolving in the light of the human genomeavailability and the complete genome sequencing of several humanpathogens. Microarray technology is a revolutionary tool for elucidatingroles of genes in infectious diseases, shifting from
Patricia Severino
doaj  

Combining gene expression data from different generations of oligonucleotide arrays

BMC Bioinformatics, 2004
Background One of the important challenges in microarray analysis is to take full advantage of previously accumulated data, both from one's own laboratory and from public repositories.
Kong Sek, Hwang Kyu-Baek, Greenberg Steve A, Park Peter J   +3 more
doaj   +1 more source

Design, validation and annotation of transcriptome-wide oligonucleotide probes for the oligochaete annelid Eisenia fetida. [PDF]

PLoS ONE, 2010
High density oligonucleotide probe arrays have increasingly become an important tool in genomics studies. In organisms with incomplete genome sequence, one strategy for oligo probe design is to reduce the number of unique probes that target every non ...
Ping Gong, Mehdi Pirooznia, Xin Guan, Edward J Perkins   +3 more
doaj   +1 more source

Efficient oligonucleotide probe selection for pan-genomic tiling arrays

BMC Bioinformatics, 2009
Background Array comparative genomic hybridization is a fast and cost-effective method for detecting, genotyping, and comparing the genomic sequence of unknown bacterial isolates.
Zhang Wei, Deng Xiangyu, Phillippy Adam M, Salzberg Steven L   +3 more
doaj   +1 more source