Results 41 to 50 of about 80,761 (229)

Secondary structure in the target as a confounding factor in synthetic oligomer microarray design

BMC Genomics, 2005
Background Secondary structure in the target is a property not usually considered in software applications for design of optimal custom oligonucleotide probes.
Gibas Cynthia J, Weller Jennifer W, Ratushna Vladyslava G   +2 more
doaj   +1 more source

MicroRNA Expression Profiling by Bead Array Technology in Human Tumor Cell Lines Treated with Interferon-Alpha-2a

Biological Procedures Online, 2009
MicroRNAs are positive and negative regulators of eukaryotic gene expression that modulate transcript abundance by specific binding to sequence motifs located prevalently in the 3' untranslated regions of target messenger RNAs (mRNA). Interferon-alpha-2a
Siegrist Fredy, Singer Thomas, Certa Ulrich   +2 more
doaj   +3 more sources

Physico-chemical foundations underpinning microarray and next-generation sequencing experiments [PDF]

, 2013
Hybridization of nucleic acids on solid surfaces is a key process involved in high-throughput technologies such as microarrays and, in some cases, next-generation sequencing (NGS).
Carlon, E, Buhot, A, Hooyberghs, J, Harrison, A., Gamble, LJ, Pozhitkov, A., Pettitt, B., Tautz, D. ; https://orcid.org/, Levicky, Rastislav, Harrison, A, Buhot, A., Carlon, E., Pozhitkov, Alexander E, Gibas, C, Halperin, A, Binder, H, Pettitt, BM, Gamble, L., Noble, P., Hooyberghs, Jef, Harrison, Andrew B., Levicky, R, Pettitt, B. Montgomery, Pozhitkov, AE, Noble, PA, Carlon, Enrico, Halperin, Avraham, Kreil, David P, Levicky, R., Ott, A, Kreil, DP, Tautz, Diethard, Binder, H., Halperin, A., Burden, Conrad John, Gibas, Cynthia, Burden, CJ, Burden, Conrad J, Kreil, David, Hooyberghs, J., Buhot, Arnaud, Gamble, Lara J., Noble, Peter A, Harrison, Andrew, Gamble, Lara J, Tautz, D, Pettitt, B Montgomery, Kreil, D., Ott, A., Binder, Hans, Burden, C., Ott, Albrecht, Pozhitkov, Alexander E., Gibas, C., Noble, Peter A.   +54 more
core   +1 more source

Gene expression analysis in microdissected renal tissue - Current challenges and strategies [PDF]

, 2002
The architecture and compartmentalization of the kidney has stimulated the development of an array of microtechniques to study the functional differences between the distinct nephron segments. With the vast amounts of genomic sequence data now available,
Cohen, C. D., Kretzler, M.
core   +1 more source

Intimate Interaction Between Nucleic Acid and Conjugated Polymers in Organic Electrochemical Transistors Enables Ultrasensitive Biomarker Detection

Advanced Materials, EarlyView.
The intimate interaction between negatively charged RNA molecules and conjugated polymers in organic electrochemical transistors (OECTs) in aqueous electrolytes is investigated. It demonstrates that RNA binding reduces the volumetric capacitance of the polymer channel, enabling the development of an ultrasensitive biosensing platform capable of ...
Hong Liu, Naixiang Wang, Anneng Yang, Jiajun Song, Li Li, Iain McCulloch, Helen Ka‐wai Law, Feng Yan   +7 more
wiley   +1 more source

High-Throughput Methods for Detection of Genetic Variation

BioTechniques, 2001
Understanding human genetic variation is currently believed to reveal the cause of individual susceptibility to disease and the large variation observed in response to treatment.
Vessela Nedelcheva Kristensen, Dimitris Kelefiotis, Tom Kristensen, Anne-Lise Børresen-Dale   +3 more
doaj   +1 more source

Minimally Invasive Delivery of Optical Nanosensors Using Injectable Hydrogels

Advanced Materials Interfaces, EarlyView.
Injectable peptide hydrogels offer a minimally invasive delivery platform for single‐walled carbon nanotube (SWCNT)‐based near‐infrared fluorescent sensors, enabling real‐time measurement of drug concentrations. Encapsulated SWCNTs show a dose‐dependent fluorescence response across physiologically relevant concentrations and retain their fluorescence ...
Shirel Kleiner, Gili Bisker
wiley   +1 more source

High-throughput Microarray Detection of Vomeronasal Receptor Gene Expression in Rodents

Frontiers in Neuroscience, 2010
We performed comprehensive data mining to explore the vomeronasal receptor (V1R & V2R) repertoires in mouse and rat using the mm5 and rn3 genome, respectively.
Xiaohong Zhang, Florencia Marcucci, Stuart Firestein   +2 more
doaj   +1 more source

Empirical Bayesian models for analysing molecular serotyping microarrays [PDF]

, 2011
Background Microarrays offer great potential as a platform for molecular diagnostics, testing clinical samples for the presence of numerous biomarkers in highly multiplexed assays.
Hinds Jason, Richard Newton, Newton Richard, Hinds, J, Wernisch, L, Lorenz Wernisch, Jason Hinds, Wernisch Lorenz, Newton, R   +8 more
core   +2 more sources

End‐to‐End Sensing Systems for Breast Cancer: From Wearables for Early Detection to Lab‐Based Diagnosis Chips

Advanced Materials Technologies, EarlyView.
This review explores advances in wearable and lab‐on‐chip technologies for breast cancer detection. Covering tactile, thermal, ultrasound, microwave, electrical impedance tomography, electrochemical, microelectromechanical, and optical systems, it highlights innovations in flexible electronics, nanomaterials, and machine learning.
Neshika Wijewardhane, Lyn I. Jones, Richard M. Martin, Helen Winter, Faezeh Arab Hassani   +4 more
wiley   +1 more source