Results 21 to 30 of about 127,617 (216)

Conformational profiling of a G-rich sequence within the c-KIT promoter [PDF]

, 2017
G-quadruplexes (G4) within oncogene promoters are considered to be promising anticancer targets. However, often they undergo complex structural rearrangements that preclude a precise description of the optimal target.
Chaires, Jonathan B, Dean, William L, Gray, Robert D, Rigo, Riccardo, Sissi, Claudia   +4 more
core   +1 more source

A zinc finger protein array for the visual detection of specific DNA sequences for diagnostic applications. [PDF]

, 2010
The visual detection of specific double-stranded DNA sequences possesses great potential for the development of diagnostics. Zinc finger domains provide a powerful scaffold for creating custom DNA-binding proteins that recognize specific DNA sequences ...
Kim, Moon-Soo, Lee, Ji Youn, Revzin, Alexander, Segal, David J, Stybayeva, Gulnaz   +4 more
core   +2 more sources

Experimental optimization of probe length to increase the sequence specificity of high-density oligonucleotide microarrays

BMC Genomics, 2007
Background High-density oligonucleotide arrays are widely used for analysis of genome-wide expression and genetic variation. Affymetrix GeneChips – common high-density oligonucleotide arrays – contain perfect match (PM) and mismatch (MM) probes generated
Kashiwagi Akiko, Furusawa Chikara, Ono Naoaki, Suzuki Shingo, Yomo Tetsuya   +4 more
doaj   +1 more source

Multiparametric determination of genes and their point mutations for identification of beta-lactamases [PDF]

, 2010
More than half of all currently used antibiotics belong to the beta-lactam group, but their clinical effectiveness is severely limited by antibiotic resistance of microorganisms that are the causative agents of infectious diseases. Several mechanisms for
A. A. Medeiros, A. Bauernfield, A. J. Brookes, A. M. Egorov, A. Nikulin, A. Philippon, A. Tamilselvi, A. Yu. Rubina, B. E. E. Cleven, B. Strommenger, C. C. Randegger, C. D. Steward, C. Heritier, C. Heritier, C. I. Birkett, C. Mabilat, C. Mugnaioli, D. E. Mudrak, D. Gryadunov, D. L. Paterson, D. L. Paterson, D. L. Paterson, D. M. Leinberger, D. M. Livermore, D. M. Livermore, D. M. Livermore, D. M. Livermore, D. M. Livermore, D. Szabo, D. V. Ivanov, E. B. Chaibi, E. M. Southern, F. Hayes, F. J. L. Robberts, F. Perez, F.-H. M’Zali, G. F. Weldhagen, H. C. Maltezou, H. F. Chambers, H. J. Monstein, H. Knothe, H. Wang, I. Massova, I. Rodriguez, I. Weigand, I. Wiegand, J. D. D. Pitout, J. D. D. Pitout, J. D. Pitout, J. D. Pitout, J. Empel, J. F. Petrosino, J. L. Jones, J. M. Ghuysen, J. Rodriguez-Bano, J. Schlesinger, J. Schmitt, J. W. Schumm, K. Bush, K. Bush, K. Bush, L. Bodrossy, L. Drieux, L. N. Ikryannikova, L. Pagani, L. Poirel, L. Poirel, L. S. Tzouvelekis, L. X. Zhu, L. Xu, L. Xu, M. Babic, M. Batchelor, M. Cassone, M. Chee, M. Edelstein, M. F. Lartigue, M. Guckenberger, M. H. Richmond, M. I. Page, M. J. Heller, M. J. Schwaber, M. J. Schwaber, M. M. Ulyashova, M. M. Ulyashova, M. Nukaga, M. Ozsoz, M. Quinteros, M. R. Mulvey, M. Schena, M. Shogo, M. Yu. Rubtsova, N. C. Strynadka, N. Datta, N. Shibata, N. Woodford, N. Woodford, P. A. James, P. Bradford, P. C. Fleming, P. M. Hawkey, R. Alonso, R. B. Sykes, R. Bonnet, R. Bonnet, R. Canton, R. D. Schmid, R. P. Ambler, S. Chen, S. Egorova, S. Harada, S. K. Du Bois, S. Kalai Blagui, S. V. Sidorenko, S. V. Sidorenko, T. L. Wu, T. Naas, T. R. Hughes, T. T. Bachmann, V. A. Doss, V. Chizhikov, V. Grimm, V. M. Ensor, V. Perreten, X. Cao, X. Yu, Y. Lee, Y. Michikawa   +127 more
core   +1 more source

Detection of minority variants within bovine respiratory syncytial virus populations using oligonucleotide-based microarrays [PDF]

, 2008
Microarray technology, originally developed for highly parallel examination of gene expression is regarded as a potential tool in prognosis and diagnosis.
Baranowski, Eric, Deplanche, Martine, François, Jean Marie, Leberre, Véronique, Trouilh, Lidwine   +4 more
core   +3 more sources

Microarrays and infectious diseases: overview and perspectives [PDF]

Einstein (São Paulo), 2005
Disease investigation is evolving in the light of the human genomeavailability and the complete genome sequencing of several humanpathogens. Microarray technology is a revolutionary tool for elucidatingroles of genes in infectious diseases, shifting from
Patricia Severino
doaj  

Combining gene expression data from different generations of oligonucleotide arrays

BMC Bioinformatics, 2004
Background One of the important challenges in microarray analysis is to take full advantage of previously accumulated data, both from one's own laboratory and from public repositories.
Kong Sek, Hwang Kyu-Baek, Greenberg Steve A, Park Peter J   +3 more
doaj   +1 more source

Design, validation and annotation of transcriptome-wide oligonucleotide probes for the oligochaete annelid Eisenia fetida. [PDF]

PLoS ONE, 2010
High density oligonucleotide probe arrays have increasingly become an important tool in genomics studies. In organisms with incomplete genome sequence, one strategy for oligo probe design is to reduce the number of unique probes that target every non ...
Ping Gong, Mehdi Pirooznia, Xin Guan, Edward J Perkins   +3 more
doaj   +1 more source

Efficient oligonucleotide probe selection for pan-genomic tiling arrays

BMC Bioinformatics, 2009
Background Array comparative genomic hybridization is a fast and cost-effective method for detecting, genotyping, and comparing the genomic sequence of unknown bacterial isolates.
Zhang Wei, Deng Xiangyu, Phillippy Adam M, Salzberg Steven L   +3 more
doaj   +1 more source

Using open access literature to guide full-text query formulation [PDF]

, 2010
*Background* Much scientific knowledge is contained in the details of the full-text biomedical literature. Most research in automated retrieval presupposes that the target literature can be downloaded and preprocessed prior to query ...
Heather A. Piwowar, Wendy W. Chapman
core   +3 more sources