Results 201 to 210 of about 130,578 (251)

Hidden network preserved in Slide-tags data allows reference-free spatial reconstruction. [PDF]

Nat Commun
Dahlberg SK, Bonet DF, Franzén L, Ståhl PL, Hoffecker IT.   +4 more
europepmc   +1 more source

Antisense oligonucleotides targeting valosin‐containing protein ameliorate muscle pathology and molecular defects in cell and mouse models of multisystem proteinopathy

Clinical and Translational Medicine, Volume 15, Issue 12, December 2025.
Multisystem proteinopathy 1 (MSP1), caused by gain‐of‐function VCP variants, leads to multisystem degeneration. Using VCP patient‐derived hiPSCs, skeletal muscle progenitor cells were generated to evaluate antisense oligonucleotide (ASO) therapy.
Pallabi Pal, Michele Carrer, Lan Weiss, Olga G. Jaime, Cheng Cheng, Alyaa Shmara, Victoria Boock, Danae Bosch, Marwan Youssef, Yasamin Fazeli, Megan Afetian, Tamar R. Grossman, Michael R. Hicks, Paymaan Jafar‐nejad, Virginia Kimonis   +14 more
wiley   +1 more source

CRISPR-Cas in actinomycetes: still a lot to be discovered. [PDF]

Microlife
Mitousis L, Musiol-Kroll E, Wohlleben W.
europepmc   +1 more source

Risk Factors for Cardiovascular and Metabolic Disease: Integrating Traditional and Novel Paradigms

iNew Medicine, Volume 1, Issue 1, December 2025.
ABSTRACT Cardiovascular and metabolic diseases (CVMD), encompassing atherosclerotic cardiovascular disease (ASCVD), heart failure, obesity, type 2 diabetes mellitus (T2DM), and metabolic dysfunction‐associated steatotic liver disease (MASLD), remain the leading global cause of morbidity and mortality.
Zhihua Wang, Shuo Chen, Suowen Xu, Jianping Weng   +3 more
wiley   +1 more source

Leading and lagging strand abasic sites differentially affect vertebrate replisome progression but involve analogous bypass mechanisms. [PDF]

Nucleic Acids Res
Cranford MT, Dahmen SN, Cortez D, Dewar JM.   +3 more
europepmc   +1 more source

Modular Nanosensing Platforms for Tuberculosis and Beyond: Engineering Biomaterials Toward Cross‐Pathogen Diagnostic Universality

MedComm – Biomaterials and Applications, Volume 4, Issue 4, December 2025.
Modular nanosensing platforms utilize nanomaterials and functionalized interfaces to amplify trace different pathogens (like tuberculosis) antigen capture, suppress matrix interference, and enable multiplex detection. Their portability and cost‐effectiveness support rapid screening in resource‐limited settings and real‐time monitoring, advancing high ...
Mei Li, Yuxin Luo, Wenqiang Li, Yiqing Wang, Yunze Tai, Zhiping Deng, Yao Luo   +6 more
wiley   +1 more source

An electrophoretic mobility shift assay with chemiluminescent readout to evaluate DNA-targeting oligonucleotide-based probes. [PDF]

PLoS One
Everly ME, Wieber PJ, Al Janabi I, Hrdlicka PJ.   +3 more
europepmc   +1 more source

Mechanical Signaling: Molecular Mechanisms, Biological Functions, Diseases, and Therapeutic Targets

MedComm, Volume 6, Issue 12, December 2025.
In this review, we summarize cell–ECM interactions and delve into the complex mechanotransduction. We introduce advanced research methods and emerging clinical tools used to study cellular mechanical phenotypes, mechanotransduction, and disease progression. Additionally, we analyze the role of mechanical biomarkers in the development and progression of
Yicen Long, Peng Wang, Jiacheng Lei, Baihai Su, Qiang Wei, Xiaojing Liu   +5 more
wiley   +1 more source

Assessing the clinical application value of SNP-array in fetal central nervous system malformations. [PDF]

Hum Genomics
Li W, Su J, Lu W, Tang X, Zhou C, Lan Y, Wei Y, Huang L, Luo J, Ou S, Tan S, Wei S, Jiang Y, Su J, Wang L, Huang M, Luo J, Huang P.   +17 more
europepmc   +1 more source

Label‐Free Electrochemical Impedance Spectroscopy for Biosensing: Evolving Interfaces and Mechanistic Insights

Small Science, Volume 5, Issue 12, December 2025.
Electrochemical impedance spectroscopy‐based label‐free biosensors offer rapid, direct, and sensitive analyte detection by measuring impedance changes in real time. Innovations in nanoengineered electrode surfaces and biorecognition elements have enhanced their performance facilitating point‐of‐care applications, despite ongoing challenges in ...
Nandhinee Radha Shanmugam, Joshua Rainbow, Jeong‐Chan Lee, Pawan Jolly, Donald E. Ingber   +4 more
wiley   +1 more source