Results 21 to 30 of about 79,402 (200)

A strategy for detection of known and unknown SNP using a minimum number of oligonucleotides applicable in the clinical settings

Journal of Translational Medicine, 2003
Detection of unknown single nucleotide polymorphism (SNP) relies on large scale sequencing expeditions of genomic fragments or complex high-throughput chip technology.
Klein Harvey, Simon Richard, Panelli Monica, Zhao Yingdong, Adams Sharon, Wang Ena, Marincola Francesco M   +6 more
doaj   +1 more source

Identical probes on different high-density oligonucleotide microarrays can produce different measurements of gene expression

BMC Genomics, 2006
Background There are many potential sources of variability in a microarray experiment. Variation can arise from many aspects of the collection and processing of samples for gene expression analysis.
Enkemann Steven A, Yoder Sean J, Zhang LanMin   +2 more
doaj   +1 more source

DNA microarrays in cancer diagnosis and prognosis [PDF]

Einstein (São Paulo), 2005
This review discusses recent advances in our understanding ofthe human genome and the application of derived technologies inthe medical area. It focuses on the use of DNA microarray fordiagnosis, prognosis, and therapeutic purposes in oncology, andthe ...
Oswaldo Keith Okamoto
doaj  

Design and evaluation of Actichip, a thematic microarray for the study of the actin cytoskeleton

BMC Genomics, 2007
Background The actin cytoskeleton plays a crucial role in supporting and regulating numerous cellular processes. Mutations or alterations in the expression levels affecting the actin cytoskeleton system or related regulatory mechanisms are often ...
Chalmel Frédéric, Muller Arnaud, Yatskou Mikalai, Vetter Guillaume, Mehlen André, Muller Jean, Poch Olivier, Friederich Evelyne, Vallar Laurent   +8 more
doaj   +1 more source

A comparison of alternative 60-mer probe designs in an in-situ synthesized oligonucleotide microarray

BMC Genomics, 2006
Background DNA microarrays have proven powerful for functional genomics studies. Several technologies exist for the generation of whole-genome arrays.
Fairbanks Benjamin D, Hume Patrick S, Karimpour-Fard Anis, Leiske Danielle L, Gill Ryan T   +4 more
doaj   +1 more source

NOTCH2 is neither rearranged nor mutated in t(1;19) positive oligodendrogliomas. [PDF]

PLoS ONE, 2009
The combined deletion of 1p and 19q chromosomal arms is frequent in oligodendrogliomas (OD) and has recently been shown to be mediated by an unbalanced t(1;19) translocation.
Magdalena Benetkiewicz, Ahmed Idbaih, Pierre-Yves Cousin, Blandine Boisselier, Yannick Marie, Emmanuelle Crinière, Khê Hoang-Xuan, Jean-Yves Delattre, Marc Sanson, Olivier Delattre   +9 more
doaj   +1 more source

Secondary structure in the target as a confounding factor in synthetic oligomer microarray design

BMC Genomics, 2005
Background Secondary structure in the target is a property not usually considered in software applications for design of optimal custom oligonucleotide probes.
Gibas Cynthia J, Weller Jennifer W, Ratushna Vladyslava G   +2 more
doaj   +1 more source

MicroRNA Expression Profiling by Bead Array Technology in Human Tumor Cell Lines Treated with Interferon-Alpha-2a

Biological Procedures Online, 2009
MicroRNAs are positive and negative regulators of eukaryotic gene expression that modulate transcript abundance by specific binding to sequence motifs located prevalently in the 3' untranslated regions of target messenger RNAs (mRNA). Interferon-alpha-2a
Siegrist Fredy, Singer Thomas, Certa Ulrich   +2 more
doaj   +3 more sources

Strong position-dependent effects of sequence mismatches on signal ratios measured using long oligonucleotide microarrays

BMC Genomics, 2008
Background Microarrays are an important and widely used tool. Applications include capturing genomic DNA for high-throughput sequencing in addition to the traditional monitoring of gene expression and identifying DNA copy number variations.
Hulme Helen, Kemp Stephen J, Noyes Harry A, Rennie Catriona, Brass Andy, Hoyle David C   +5 more
doaj   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source