Results 31 to 40 of about 708,274 (274)
Design and evaluation of Actichip, a thematic microarray for the study of the actin cytoskeleton
BMC Genomics, 2007 Background The actin cytoskeleton plays a crucial role in supporting and regulating numerous cellular processes. Mutations or alterations in the expression levels affecting the actin cytoskeleton system or related regulatory mechanisms are often ...
Chalmel Frédéric +8 more
doaj +1 more source
Genetics in Medicine, 2008 Purpose: The goal of this work was to test the ability of oligonucleotide-based arrays to reproduce the results of focused bacterial artificial chromosome (BAC)-based arrays used clinically in comparative genomic hybridization experiments to detect ...
Z. Ou +8 more
semanticscholar +1 more source
Biological Procedures Online, 2009 MicroRNAs are positive and negative regulators of eukaryotic gene expression that modulate transcript abundance by specific binding to sequence motifs located prevalently in the 3' untranslated regions of target messenger RNAs (mRNA). Interferon-alpha-2a
Siegrist Fredy +2 more
doaj +3 more sources
DNA microarrays in cancer diagnosis and prognosis [PDF]
Einstein (São Paulo), 2005 This review discusses recent advances in our understanding ofthe human genome and the application of derived technologies inthe medical area. It focuses on the use of DNA microarray fordiagnosis, prognosis, and therapeutic purposes in oncology, andthe ...
Oswaldo Keith Okamoto
doaj
BMC Genomics, 2006 Background DNA microarrays have proven powerful for functional genomics studies. Several technologies exist for the generation of whole-genome arrays.
Fairbanks Benjamin D +4 more
doaj +1 more source
NOTCH2 is neither rearranged nor mutated in t(1;19) positive oligodendrogliomas. [PDF]
PLoS ONE, 2009 The combined deletion of 1p and 19q chromosomal arms is frequent in oligodendrogliomas (OD) and has recently been shown to be mediated by an unbalanced t(1;19) translocation.
Magdalena Benetkiewicz +9 more
doaj +1 more source
Thermodynamics of RNA/DNA hybridization in high density oligonucleotide microarrays [PDF]
Physica A 362, 433 (2006), 2004 We analyze a series of publicly available controlled experiments (Latin square) on Affymetrix high density oligonucleotide microarrays using a simple physical model of the hybridization process. We plot for each gene the signal intensity versus the hybridization free energy of RNA/DNA duplexes in solution, for perfect matching and mismatching probes ...
arxiv +1 more source
Secondary structure in the target as a confounding factor in synthetic oligomer microarray design
BMC Genomics, 2005 Background Secondary structure in the target is a property not usually considered in software applications for design of optimal custom oligonucleotide probes.
Gibas Cynthia J +2 more
doaj +1 more source
DNA sequence correlations shape nonspecific transcription factor-DNA binding affinity [PDF]
Biophys. J. 101(1), 160-166 (2011), 2011 Transcription factors (TFs) are regulatory proteins that bind DNA in promoter regions of the genome and either promote or repress gene expression. Here we predict analytically that enhanced homo-oligonucleotide sequence correlations, such as poly(dA:dT) and poly(dC:dG) tracts, statistically enhance non-specific TF-DNA binding affinity.
arxiv +1 more source
BMC Genomics, 2008 Background Microarrays are an important and widely used tool. Applications include capturing genomic DNA for high-throughput sequencing in addition to the traditional monitoring of gene expression and identifying DNA copy number variations.
Hulme Helen +5 more
doaj +1 more source