Results 51 to 60 of about 740,905 (276)
Solving the riddle of the bright mismatches: hybridization in oligonucleotide arrays [PDF]
, 2002 HDONA technology is predicated on two ideas. First, the differential between high-affinity (perfect match, PM) and lower-affinity (mismatch, MM) probes is used to minimize cross-hybridization. Second, several short probes along the transcript are combined, introducing redundancy.
arxiv +1 more source
Single-molecule DNA Bases Discrimination in Oligonucleotides by Controllable Trapping in Plasmonic Nanoholes [PDF]
Nature Communications 10, 5321 (2019), 2019 Surface-enhanced Raman spectroscopy (SERS) sensing of DNA sequences by plasmonic nanopores could pave a way to new generation single-molecule sequencing platforms. The SERS discrimination of single DNA bases depends critically on the time that a DNA strand resides within the plasmonic hot spot.
arxiv +1 more source
Ubiquitination of transcription factors in cancer: unveiling therapeutic potential
Molecular Oncology, EarlyView.In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley +1 more source
High-throughput Microarray Detection of Vomeronasal Receptor Gene Expression in Rodents
Frontiers in Neuroscience, 2010 We performed comprehensive data mining to explore the vomeronasal receptor (V1R & V2R) repertoires in mouse and rat using the mm5 and rn3 genome, respectively.
Xiaohong Zhang +2 more
doaj +1 more source
G-spots cause incorrect expression measurement in Affymetrix microarrays [PDF]
, 2008 Background High Density Oligonucleotide arrays (HDONAs), such as the Affymetrix HG-U133A GeneChip, use sets of probes chosen to match specified genes, with the expectation that if a particular gene is highly expressed then all the probes in ...
Harrison, Andrew P +2 more
core +2 more sources
DNA detection by THz pumping [PDF]
, 2014 Our results demonstrate a new method for label-free, real-time oligonucleotide characterisation by their self-resonant modes, which are unique to their conformation and sequence. We anticipate that our assay will be used as a starting point for a more detailed investigation of the aforementioned mechanism, which can be used as a basis for ...
arxiv +1 more source
Au-Ag template stripped pattern for scanning probe investigations of DNA arrays produced by Dip Pen Nanolithography [PDF]
Langmuir 24, 13212-13217 (2008), 2008 We report on DNA arrays produced by Dip Pen Nanolithography (DPN) on a novel Au-Ag micro patterned template stripped surface. DNA arrays have been investigated by atomic force microscopy (AFM) and scanning tunnelling microscopy (STM) showing that the patterned template stripped substrate enables easy retrieval of the DPN-functionalized zone with a ...
arxiv +1 more source
Structured Light Projection Using Image Guide Fibers for In Situ Photo‐biofabrication
Advanced Materials, EarlyView.Light‐based biofabrication is typically performed with single wavelength light sources and within benchtop devices. This work demonstrates FaSt‐Light (Fiber‐assisted Structured Light) as a new approach to achieve multiwavelength image projection using flexible image guide fibers, which enables a variety of applications for in situ biofabrication ...
Parth Chansoria +8 more
wiley +1 more source
BMC Bioinformatics, 2009 Background The Affymetrix MitoChip v2.0 is an oligonucleotide tiling array for the resequencing of the human mitochondrial (mt) genome. For each of 16,569 nucleotide positions of the mt genome it holds two sets of four 25-mer probes each that match the ...
Spang Rainer +5 more
doaj +1 more source
Systems Biology and the Development of Vaccines and Drugs for Malaria Treatments [PDF]
, 2006 The sequencing race has ended and the functional race has already begun. Microarray technology enables simultaneous gene expression analysis of thousands of genes, enabling a snapshot of an organisms’ transcriptome at an unprecedented resolution.
Adebiyi, E. F.
core +1 more source