Results 71 to 80 of about 23,719,178 (251)

Identifying a Csmd3+ Microglial Subpopulation that Drives Cold‐to‐Hot Transition and Immune‐Cure in Glioblastoma

Advanced Science, EarlyView.
The study establishes an immune‐cure (ICu) mouse model based on a TMEMed G422TN‐GBM system that faithfully recapitulates human TMEMed GBM. scRNA‐seq analysis reveals a Csmd3+ microglial subset with innate immune memory (IIM) potential that potently suppresses GBM growth, drives a TME cold‐to‐hot transition, and induces 100% ICu in long‐term survival ...
Hai‐Feng Jiang, Pan‐Pan Gao, Yu‐Wen Du, Li‐Qin Wu, En‐Zhi Yin, Qi An, Ze‐Hua Ding, Jin‐Wen Shi, Ya Shu, Ruoqiao Chen, Feng Liu, Mingfeng Li, Xiao Qian Chen   +12 more
wiley   +1 more source

Oligonucleotide array discovery of polymorphisms in cultivated tomato (Solanum lycopersicum L.) reveals patterns of SNP variation associated with breeding

BMC Genomics, 2009
Background Cultivated tomato (Solanum lycopersicum L.) has narrow genetic diversity that makes it difficult to identify polymorphisms between elite germplasm.
Zhu Tong, Chilcott Charles, Robbins Matthew D, Sim Sung-Chur, Francis David M   +4 more
doaj   +1 more source

Characterisation of Hardenbergia mosaic virus and development of microarrays for detecting viruses in plants [PDF]

, 2008
A virus causing chlorosis and leaf distortion in the Western Australian endemic legume Hardenbergia comptoniana was detected by biological indexing to Chenopodium quinoa and Nicotiana benthamiana. Enzyme linked immuno-sorbent assay (ELISA) using general
Webster, Craig Graham
core  

SemanticST: A Scalable Multi‐Contextual Graph Learning Framework for Uncovering Spatial Niches and Robust Multi‐Sample Integration in Spatial Transcriptomics

Advanced Science, EarlyView.
Technical limitations often let dominant signals overshadow rare cell types and fine‐grained heterogeneity in spatial transcriptomics. SemanticST, a graph neural network using multi‐semantic graph fusion and a novel min‐cut loss, recovers these subtle patterns.
Roxana Zahedi, Ahmadreza Argha, Nona Farbehi, Ivan Bakhshayeshi, Thantrira Porntaveetus, Youqiong Ye, Nigel H. Lovell, Hamid Alinejad‐Rokny   +7 more
wiley   +1 more source

Discovery and mapping of single feature polymorphisms in wheat using Affymetrix arrays

BMC Genomics, 2009
Background Wheat (Triticum aestivum L.) is a staple food crop worldwide. The wheat genome has not yet been sequenced due to its huge genome size (~17,000 Mb) and high levels of repetitive sequences; the whole genome sequence may not be expected in the ...
Hu Shengwa, Ma Hongxiang, Bradbury Peter J, Bernardo Amy N, Bowden Robert L, Buckler Edward S, Bai Guihua   +6 more
doaj   +1 more source

Detection of eight foodborne bacterial pathogens by oligonucleotide array hybridization [PDF]

, 2017
Background: Simultaneous and rapid detection of multiple foodborne bacterial pathogens is important for the prevention of foodborne illnesses. Objective: The aim of this study was to evaluate the use of 16S rDNA and 23S rDNA sequences as targets for ...
Zohreh Nasrabadi, Meysam Sarshar, Fatemeh Poorali, Reza Ranjbar   +3 more
core   +1 more source

Dual‐line Genome‐scale CRISPR Screening Enables Robust Target Gene Discovery

Advanced Science, EarlyView.
A species‐optimized CRISPR platform integrates efficient piggyBac delivery, genome‐scale sgRNA libraries, and parallel screening in two independently engineered Bactrocera dorsalis Cas9 cell lines. Cross‐line consensus analysis filters line‐specific effects, enriches candidates with reproducible in vivo phenotypes, and reveals conserved, species ...
Ziniu Li, Jiao Qiao, Qiuyuan Zhang, Peipei Liu, Chenjun Zheng, Qi Zhou, Mengqi Ji, Zhihui Zhu, Xiaoxue Li, Hongyu Zhang   +9 more
wiley   +1 more source

Positional weight matrix as a sequence motif detector

, 2008
In biological sequence research, the positional weight matrix (PWM) is often used for motif signal detection. A set of experimentally verified oligonucleotides known to be functional subsequences, which can be bound by a transcription factor (TF), as ...
Phan, Sieu, Pan, Youlian
core   +1 more source

Microarray-based analysis of differential gene expression between infective and noninfective larvae of Strongyloides stercoralis.

PLoS Neglected Tropical Diseases, 2011
BackgroundDifferences between noninfective first-stage (L1) and infective third-stage (L3i) larvae of parasitic nematode Strongyloides stercoralis at the molecular level are relatively uncharacterized. DNA microarrays were developed and utilized for this
Roshan Ramanathan, Sudhir Varma, José M C Ribeiro, Timothy G Myers, Thomas J Nolan, David Abraham, James B Lok, Thomas B Nutman   +7 more
doaj   +1 more source

Oligonucleotide designation and sequence.

, 2015
Oligonucleotide designation and sequence.
Eva Serrano-Candelas (510769), David Aparicio (780619), Álvaro Aranguren-Ibáñez (510770), Rosa Pérez-Luque (243162), Alicia Guasch (780618), Mercè Pérez-Riba (510772), M. Carmen Mulero (780620), Sergio Martínez-Høyer (510771), Ignacio Fita (170337)   +8 more
core   +1 more source