Results 61 to 70 of about 708,274 (274)

Early BMI Change, Cognitive Decline, and CSF AD Biomarkers Alterations in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the relationship of early BMI change with subsequent cognitive decline, CSF AD biomarkers alterations, and progression to dementia in patients with PD. Methods Study data were prospectively collected from the PPMI cohort. Weight/height data at enrollment and second‐year clinical visit were utilized to calculate BMI change.
Rui Zhong, Kezhong Zhang
wiley   +1 more source

Oligonucleotide separation techniques for purification and analysis: What can we learn for today's tasks?

ELECTROPHORESIS, Volume 43, Issue 23-24, Page 2402-2427, December 2022., 2022
Abstract Nucleic acids are the blueprint of life. They are not only the construction plan of the single cell or higher associations of them, but also necessary for function, communication and regulation. Due to the pandemic, the attention shifted in particular to their therapeutic potential as a vaccine. As pharmaceutical oligonucleotides are unique in
Robert Minkner, Jirayu Boonyakida, Enoch Y. Park, Hermann Wätzig   +3 more
wiley   +1 more source

Time-Resolved Sequence Analysis on High Density Fiberoptic DNA Probe

, 2002
A universal array format has been developed in which all possible n-mers of a particular oligonucleotide sequence can be represented. The ability to determine the sequence of the probes at every position in the array should enable unbiased gene ...
D. Walt, K. Lee
semanticscholar   +1 more source

Multilocus Sequence Typing of Staphylococcus aureus with DNA Array Technology

Journal of Clinical Microbiology, 2003
A newly developed oligonucleotide array suited for multilocus sequence typing (MLST) of Staphylococcus aureus strains was analyzed with two strain collections in a two-center study.
W. V. van Leeuwen, C. Jay, S. Snijders, N. Durin, Bruno Lacroix, H. A. Verbrugh, M. Enright, A. Troesch, A. van Belkum   +8 more
semanticscholar   +1 more source

Engineering CAR‐T Therapeutics for Enhanced Solid Tumor Targeting

Advanced Materials, EarlyView.
CART cell therapy has proven effective for blood cancers but struggles with solid tumors due to diverse antigens and complex environments. Recent efforts focus on improving CAR design and validation platforms. Advances in protein engineering, machine learning, and organoid systems aim to enhance CAR‐T therapy against solid tumors.
Danqing Zhu, Won Joon Kim, Hyunjin Lee, Xiaoping Bao, Pilnam Kim   +4 more
wiley   +1 more source

Specific and non specific hybridization of oligonucleotide probes on microarrays [PDF]

, 2004
Gene expression analysis by means of microarrays is based on the sequence specific binding of mRNA to DNA oligonucleotide probes and its measurement using fluorescent labels. The binding of RNA fragments involving other sequences than the intended target is problematic because it adds a "chemical background" to the signal, which is not related to the ...
arxiv   +1 more source

A simple optimization can improve the performance of single feature polymorphism detection by Affymetrix expression arrays

BMC Genomics, 2010
Background High-density oligonucleotide arrays are effective tools for genotyping numerous loci simultaneously. In small genome species (genome size: < ~300 Mb), whole-genome DNA hybridization to expression arrays has been used for various applications ...
Fujisawa Hironori, Harushima Yoshiaki, Horiuchi Youko, Mochizuki Takako, Kawakita Masanori, Sakaguchi Takayuki, Kurata Nori   +6 more
doaj   +1 more source

DNA‑Directed Assembly of Photonic Nanomaterials for Diagnostic and Therapeutic Applications

Advanced Materials, EarlyView.
DNA‐directed assembly offers a powerful strategy for constructing structured photonic nanomaterials with precise spatial control. This review provides a comprehensive overview of recent advancements in DNA‐assembled photonic nanomaterials for diagnostics and therapeutics, highlighting key design principles, functionalization strategies, and optical ...
Longjiang Ding, Bing Liu, Andreas Peil, Sisi Fan, Jie Chao, Na Liu   +5 more
wiley   +1 more source

Alternative mapping of probes to genes for Affymetrix chips

BMC Bioinformatics, 2004
Background Short oligonucleotide arrays have several probes measuring the expression level of each target transcript. Therefore the selection of probes is a key component for the quality of measurements.
Friis-Hansen Lennart, Møller Morten, Gautier Laurent, Knudsen Steen   +3 more
doaj   +1 more source

Custom Design and Analysis of High-Density Oligonucleotide Bacterial Tiling Microarrays

PLoS ONE, 2009
Background High-density tiling microarrays are a powerful tool for the characterization of complete genomes. The two major computational challenges associated with custom-made arrays are design and analysis.
G. Thomassen, A. Rowe, Karin Lagesen, Jessica M Lindvall, Torbjørn Rognes   +4 more
semanticscholar   +1 more source