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The Two Faces of the Guanyl Radical: Molecular Context and Behavior
Molecules, 2021 The guanyl radical or neutral guanine radical G(-H)• results from the loss of a hydrogen atom (H•) or an electron/proton (e–/H+) couple from the guanine structures (G). The guanyl radical exists in two tautomeric forms.
Chryssostomos Chatgilialoglu
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Nanoparticles-Based Oligonucleotides Delivery in Cancer: Role of Zebrafish as Animal Model
Pharmaceutics, 2021 Oligonucleotide (ON) therapeutics are molecular target agents composed of chemically synthesized DNA or RNA molecules capable of inhibiting gene expression or protein function.
Sara Bozzer +4 more
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Dendriplex-Impregnated Hydrogels With Programmed Release Rate
Frontiers in Chemistry, 2022 Hydrogels are biocompatible matrices for local delivery of nucleic acids; however, functional dopants are required to provide efficient delivery into cells. In particular, dendrimers, known as robust nucleic acid carriers, can be used as dopants. Herein,
Evgeny Apartsin +8 more
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Modular Synthesis of Trifunctional Peptide-oligonucleotide Conjugates via Native Chemical Ligation
Frontiers in Chemistry, 2021 Cell penetrating peptides (CPPs) are being increasingly used as efficient vectors for intracellular delivery of biologically active agents, such as therapeutic antisense oligonucleotides (ASOs).
Mohadeseh Dastpeyman +5 more
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Antisense Oligonucleotides: An Emerging Area in Drug Discovery and Development
Journal of Clinical Medicine, 2020 Antisense oligonucleotides (ASOs) bind sequence specifically to the target RNA and modulate protein expression through several different mechanisms. The ASO field is an emerging area of drug development that targets the disease source at the RNA level ...
Karishma Dhuri +6 more
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Diamonds for Life: Developments in Sensors for Biomolecules
Applied Sciences, 2022 Diamond-based electrodes and biosensors are interesting in analytics because of their particular set of properties, namely: large potential window, chemical inertness, low baseline current, stability, and transparency.
Nádia E. Santos +5 more
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Cells, 2023 Interleukin-6 (IL-6) is a pleiotropic cytokine that plays a crucial role in maintaining normal homeostatic processes under the pathogenesis of various inflammatory and autoimmune diseases.
Dhanu Gupta +6 more
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The powerful world of antisense oligonucleotides: From bench to bedside
Wiley Interdisciplinary Reviews - RNA, 2020 Antisense oligonucleotides (ASOs) represent a new and highly promising class of drugs for personalized medicine. In the last decade, major chemical developments and improvements of the backbone structure of ASOs have transformed them into true approved ...
Anaïs M. Quéméner +5 more
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Single-Stranded Oligonucleotide-Mediated Inhibition of Respiratory Syncytial Virus Infection
Frontiers in Immunology, 2020 Respiratory syncytial virus (RSV) is the leading cause of acute lower respiratory tract infections in young children. Currently, there is no RSV vaccine or universally accessible antiviral treatment available. Addressing the urgent need for new antiviral
Sandra Axberg Pålsson +14 more
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Bioconjugated Oligonucleotides: Recent Developments and Therapeutic Applications. [PDF]
Bioconjugate chemistry, 2019 Oligonucleotide-based agents have the potential to treat or cure almost any disease, and are one of the key therapeutic drug classes of the future.
S. Benizri +5 more
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