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Bioconjugated oligonucleotides: recent developments and thera-eutic applications [PDF]
Bioconjugate Chemistry, American Chemical Society, 2019, 30,
pp.366-383, 2020 Oligonucleotide-based agents have the potential to treat or cure almost any disease, and are one of the key therapeutic drug classes of the future. Bioconjugated oligonucleotides, a subset of this class, are emerging from basic research and being successfully translated to the clinic.
S. Benizri +5 more
arxiv +3 more sources
The delivery of therapeutic oligonucleotides [PDF]
Nucleic Acids Research, 2016 The oligonucleotide therapeutics field has seen remarkable progress over the last few years with the approval of the first antisense drug and with promising developments in late stage clinical trials using siRNA or splice switching oligonucleotides ...
R. Juliano
semanticscholar +4 more sources
Antisense oligonucleotides [PDF]
Neurology Genetics, 2019 There are few disease-modifying therapeutics for neurodegenerative diseases, but successes on the development of antisense oligonucleotide (ASO) therapeutics for spinal muscular atrophy and Duchenne muscular dystrophy predict a robust future for ASOs in ...
Daniel R. Scoles, E. Minikel, S. Pulst
semanticscholar +4 more sources
Biodynamic effects of oligonucleotides [PDF]
Bacteriological Reviews, 1967 Werner Braun, William Firshein
openalex +4 more sources
Dendriplex-Impregnated Hydrogels With Programmed Release Rate
Frontiers in Chemistry, 2022 Hydrogels are biocompatible matrices for local delivery of nucleic acids; however, functional dopants are required to provide efficient delivery into cells. In particular, dendrimers, known as robust nucleic acid carriers, can be used as dopants. Herein,
Evgeny Apartsin +8 more
doaj +1 more source
Making Oligonucleotide Conjugates and Breaking Oligonucleotides [PDF]
Nucleic Acids Symposium Series, 2007 Presented is our most recent work on synthesis and properties of oligonucleotide analogues and conjugates These include 2'-carbamoylmethyl derivatives, peptideoligonucleotide conjugates and conjugates made to combine Watson-Crick and non-Watson-Crick interactions as well as conjugates with RNA-cleaving groups.
Esther Yeheskiely +4 more
openaire +3 more sources
Modular Synthesis of Trifunctional Peptide-oligonucleotide Conjugates via Native Chemical Ligation
Frontiers in Chemistry, 2021 Cell penetrating peptides (CPPs) are being increasingly used as efficient vectors for intracellular delivery of biologically active agents, such as therapeutic antisense oligonucleotides (ASOs).
Mohadeseh Dastpeyman +5 more
doaj +1 more source
Antisense Oligonucleotides: An Emerging Area in Drug Discovery and Development
Journal of Clinical Medicine, 2020 Antisense oligonucleotides (ASOs) bind sequence specifically to the target RNA and modulate protein expression through several different mechanisms. The ASO field is an emerging area of drug development that targets the disease source at the RNA level ...
Karishma Dhuri +6 more
semanticscholar +1 more source
Modeling of nucleobase/oligonucleotide interaction with graphene and graphene oxide: the role of charging and/or oxidizing the graphene surface [PDF]
Mol. Cryst. Liq. Cryst. 2020, Vol. 697(1), 49-59, 2021 We analyze the influence of the charge and the degree of oxidation of the surface of graphene (Gr) on its interaction with cytosine and oligonucleotide r(C)10. This is a computational study involving DFT calculations and molecular dynamics simulations. It is shown that cytosine interacts stronger with graphene oxide (GO) than with Gr, while the energy ...
arxiv +1 more source
Cells, 2023 Interleukin-6 (IL-6) is a pleiotropic cytokine that plays a crucial role in maintaining normal homeostatic processes under the pathogenesis of various inflammatory and autoimmune diseases.
Dhanu Gupta +6 more
doaj +1 more source