Erratum: <i>In vivo</i> efficacy and safety of systemically administered serinol nucleic acid-modified antisense oligonucleotides in mouse kidney. [PDF]
Mol Ther Nucleic AcidsTsuboi T +12 more
europepmc +1 more source
Bacterial transcriptional repressor NrdR – a flexible multifactorial nucleotide sensor
The FEBS Journal, EarlyView.NrdR is a bacterial transcription factor that regulates the expression of all three types of ribonucleotide reductase, an essential enzyme for cell survival, in response to intracellular ATP and dATP levels. We have carried out a comprehensive biochemical, biophysical and structural study of the response of E. coli NrdR to ATP and dATP.
Inna Rozman Grinberg +9 more
wiley +1 more source
Decoding the genetic blueprints of neurological disorders: disease mechanisms and breakthrough gene therapies. [PDF]
Front NeurolSaeed U +8 more
europepmc +1 more source
Unraveling the functional dynamics of Caenorhabditis elegans stress‐responsive omega class GST‐44
The FEBS Journal, EarlyView.Omega‐class glutathione S‐transferases (GSTs) are integral to redox regulation and cellular stress responses. This study characterized GST‐44 in Caenorhabditis elegans, revealing its predominant expression in the intestine and excretory H‐cell, with significant upregulation under various stress conditions.
Charlotte Sophia Kaiser +9 more
wiley +1 more source
Musashi-dependent mRNA translational activation is mediated through association with the Scd6/Like-sm family member, LSM14B. [PDF]
Sci RepBronson K +7 more
europepmc +1 more source
Loss of Adenosine Deaminase Acting on RNA 1 Induces Panoptosis and Immune Response in Ulcerative Colitis Gut Mucosa [PDF]
MedComm (2020)The gut virome is a complex community that, when disrupted, may contribute to inflammatory diseases like IBD. We found that ADAR1 expression is reduced in gut inflamed mucosa of ulcerative colitis patients. ADAR1 silencing heightened activation of inflammatory pathways and PANoptosis exacerbating gut tissue damage, but JAK inhibition or AhR activation ...
Iannucci A +13 more
europepmc +2 more sources
Type I interferon signalling and interferon‐responsive microglia in health and disease
The FEBS Journal, EarlyView.Recent insights reveal that type I interferon (IFN‐I) signalling plays critical roles in the nervous system beyond antiviral defence. Dysregulated IFN‐I activity is increasingly linked to neurological dysfunction and neurodegeneration, with microglia as central mediators. This review explores the broader impact of IFN‐I signalling on the nervous system
Jose P. Lopez‐Atalaya +1 more
wiley +1 more source
The FEBS Journal, EarlyView.Neuronal migration plays essential roles in the establishment of mammalian brains, and its impairment causes severe developmental abnormalities and behavioral and cognitive deficits. Here, we report that cadherin‐6 (CDH6), an unusual cadherin molecule containing an RGD integrin‐binding motif in the first extracellular domain, controls the motility of ...
Yuki Hirota +7 more
wiley +1 more source
Cross-species translational modelling of targeted therapeutic oligonucleotides using physiologically based pharmacokinetics. [PDF]
J Pharmacokinet PharmacodynDerbalah A +8 more
europepmc +1 more source
Alternative Splicing Regulation in Metabolic Disorders
Obesity Reviews, EarlyView.ABSTRACT Alternative splicing (AS) is a fundamental mechanism for enhancing transcriptome diversity and regulating gene expression, crucial for various cellular processes and the development of complex traits. This review examines the role of AS in metabolic disorders, including obesity, weight loss, dyslipidemias, and metabolic syndrome.
Dorota Kaminska
wiley +1 more source